Results 31 to 40 of about 5,116,032 (159)

Prospects for the use of growth regulators in vegetative propagation technology of La-vandula angustifolia

open access: yesRegulatory Mechanisms in Biosystems
Lavenders include some 28 species of evergreen aromatic shrubs and subshrubs belonging to the mint family, the Lamiaceae. They occur mainly around the Mediterranean and their flowers range from pink to purple and white.
O. Kobets   +3 more
doaj   +1 more source

Biochemical Characterization of an Atypical Variant Flanking or Affecting the Initiation or Start Methionine Codon in CHST14 in a Patient With Musculocontractural Ehlers–Danlos Syndrome

open access: yesProteoglycan Research, Volume 4, Issue 1, January 2026.
ABSTRACT Musculocontractural Ehlers‐Danlos syndrome (EDS) caused by pathogenic variants in the carbohydrate sulfotransferase 14 gene (CHST14) (mcEDS‐CHST14) is an autosomal recessive connective tissue disorder characterized by congenital malformations including specific craniofacial features, congenital multiple contractures, and progressive fragility ...
Shuji Mizumoto   +7 more
wiley   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

open access: yesFEBS Open Bio, Volume 15, Issue 10, Page 1552-1569, October 2025.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis   +3 more
wiley   +1 more source

Molecular Evolution and Gene Diversity of Dermatan Sulfate Sulfotransferases in Ascidians

open access: yesProteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT Ascidians (Chordata, Tunicata) are model organisms for studying molecules, particularly sulfated glycosaminoglycans (GAGs), due to their phylogenetic proximity to vertebrates and unique GAG variants. Over‐sulfated dermatan sulfate (DS) contributes to proteoglycan diversity and cellular processes in metazoans.
Vanessa de Sousa Rizzo‐Valente   +1 more
wiley   +1 more source

The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives

open access: yesThe FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Heparanase 1 (HPSE1) and Heparanase 2 (HPSE2) exhibit opposing expression patterns and functions in pathological contexts, such as cancer. Here, we describe their specific expression in immune cells and their implications in skin diseases. Although they are structurally similar and considered to be ‘cousins’, we found no common ancestor and that HPSE2 ...
Elham Vahdatahar   +12 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, Volume 599, Issue 15, Page 2190-2200, August 2025.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Unlocking New Pharma/Nutraceutical Frontiers With Neuroprotective Properties of Three Hypericum Species: A Study Combination With In Vitro and In Silico Methodologies

open access: yesFood Science &Nutrition, Volume 13, Issue 4, April 2025.
This study investigates the phytochemical composition and biopharmacological potential of the extracts from three Hypericum species (H. scabrum, H. lysimachioides, and H. uniglandulosum) from Turkey. The results indicate significant therapeutic potential for these extracts, supporting their development as natural agents against oxidative stress ...
Muammer Bahsi   +12 more
wiley   +1 more source

Alveolar Glycocalyces During Health and Critical Illness

open access: yesProteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT The alveolus, the functional unit of the lung, is comprised of closely approximated alveolar epithelial and endothelial cells, across which gas exchange occurs. This alveolar septum also includes two substantial, intraluminal extracellular matrices: the alveolar epithelial and endothelial glycocalyces.
Yimu Yang, Eric P. Schmidt
wiley   +1 more source

Disaccharide Analysis of Glycosaminoglycans From Twenty‐Four Organs of Young and Aged Mice

open access: yesProteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT Glycosaminoglycans (GAGs) are abundant negatively charged polysaccharides ubiquitously expressed in mammalian organs, having essential biological functions in development and homeostasis. It has been scarcely reported that GAG structures are changed in aged and diseased human organs; however, an overall landscape of GAGs in individual organs ...
Emil Tykesson   +3 more
wiley   +1 more source

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