Results 161 to 170 of about 4,130 (205)
Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy. [PDF]
Mol Ther Nucleic AcidsDzianisava V +3 more
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The unfolded protein response in progeria arteries originates from non-endothelial cell types. [PDF]
Life Sci AllianceSilva RA +4 more
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Farnesyltransferase inhibition in HGPS
Cell, 2021 The ultra-rare, pediatric premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) is caused by mutation of LMNA, encoding the nuclear architectural protein lamin A. Patients develop atherosclerosis and typically die of heart failure in their teens.
Tom Misteli
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Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells [PDF]
Cells, 2016 Progeroid laminopathies, including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated aging diseases caused by defects in nuclear A-type Lamins. Most HGPS patients carry a de novo point mutation within exon 11 of the
Nicolas Levy, Claire Navarro
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Scientific Reports, 2016 Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder that causes systemic accelerated aging in children. Thanks to the pluripotency and self-renewal properties of induced pluripotent stem cells (iPSC), HGPS iPSC-based modeling ...
Nicolas Levy, Lino Ferreira
exaly +3 more sources
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Discordant Gene Expression Signatures and Related Phenotypic Differences in Lamin A- and A/C-Related Hutchinson-Gilford Progeria Syndrome (HGPS) [PDF]
PLoS ONE, 2011 Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina.
Karl Heinimann +2 more
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