Results 171 to 180 of about 4,130 (205)

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

Journal of Cell Science, 2010
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature-aging syndrome caused by a dominant mutation in the gene encoding lamin A, which leads to an aberrantly spliced and processed protein termed progerin.
Erica K. Benson, Sam W. Lee, Stuart A. Aaronson   +2 more
exaly   +2 more sources

Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery

Ageing Research Reviews, 2015
Progeria, or Hutchinson-Gilford progeria syndrome (HGPS), is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children.
Xavier Nissan
exaly   +2 more sources

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways [PDF]

Biogerontology, 2019
© The Author(s) 2019. Hutchinson–Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin A.
David Tree, Evgeny Makarov, Joanna Bridger   +2 more
exaly   +2 more sources

Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes

Scientific Reports, 2018
International audienceHutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that leads to premature aging. In this study, we used induced pluripotent stem cells to investigate the hypopigmentation phenotypes observed in patients with ...
Nicolas Levy, Christine Baldeschi
exaly   +3 more sources

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HGPS Animal Models

2021
exaly   +2 more sources

HGPS Model Organisms

2021
exaly   +2 more sources

WELL TEST ANALYSIS OF HGP-A

Proceedings of SPE California Regional Meeting, 1979
Abstract Since the successful initial flashing on July 2, 1976, HGP-A has undergone five flash discharge tests with the longest one lasting 42 days. Production records including wellhead pressure and Production records including wellhead pressure and temperature, production rate and steam quality were kept for ...
B.H. Chen, D.H. Kihara, A. Seki, P.C. Yuen   +3 more
openaire   +1 more source

Inflammation and Fibrosis in Progeria: Organ-Specific Responses in an HGPS Mouse Model

International Journal of Molecular Sciences
Hutchinson–Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder that causes accelerated aging, due to a pathogenic variant in the LMNA gene.
Karima Djabali, Eva-Maria Lederer, Moritz Schroll   +2 more
exaly   +2 more sources

Impact of HGP on Molecular Diagnostics

2009
The Human Genome Project has heralded a whole new era in our understanding of the molecular basis of disease. New opportunities now arise to predict disease by genetic testing, and in some cases to prevent disease through surveillance or other specific interventions. Increasingly it will be possible to test for predisposition to disease, to develop new
Mousumi Debnath, Godavarthi B.K.S. Prasad, Prakash S. Bisen   +2 more
openaire   +1 more source

Geologické vyhodnotenie hlbokých vrtov HGP-1, HGP-2 a HGP-3 / Geological evaluation of hydrogeological wells HGP-1, HGP-2 a HGP-3

2023
Pelech, Ondrej, Olšavský, Mário, Hraško, Lubomir, Mikudíková, Marika, Kronome, Balázs   +4 more
openaire   +1 more source