Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani +11 more
doaj +9 more sources
Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]
Frontiers in Immunology, 2022 Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian +7 more
doaj +14 more sources
HHV-6A infection induces amyloid-beta expression and activation of microglial cells [PDF]
Alzheimer’s Research & Therapy, 2019 Background The control of viral infections in the brain involves the activation of microglial cells, the macrophages of the brain that are constantly surveying the central nervous system, and the production of amyloid-beta (Aβ) as an anti-microbial ...
Daria Bortolotti +4 more
doaj +10 more sources
HHV-6A Infection and Systemic Sclerosis: Clues of a Possible Association [PDF]
Microorganisms, 2019 Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, excessive extracellular matrix deposition, and fibrosis of the skin and internal organs.
Elisabetta Caselli +7 more
doaj +13 more sources
HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B [PDF]
Viruses, 2017 Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of ...
Vanessa Collin, Louis Flamand
doaj +7 more sources
High incidence and viral load of HHV-6A in a multi-centre kidney transplant cohort [PDF]
Frontiers in Transplantation, 2023 Human herpesvirus 6 (HHV-6) is a common opportunistic pathogen in kidney transplant recipients. Two distinct species of HHV-6, HHV-6A and HHV-6B, have been identified, of which the latter seems to be dominant. However, it is unclear whether they increase
Arturo Blazquez-Navarro +21 more
doaj +6 more sources
DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]
Frontiers in Microbiology, 2020 ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti +11 more
doaj +7 more sources
The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration. [PDF]
PLoS Pathogens, 2016 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types.
Nina Wallaschek +6 more
doaj +9 more sources
The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility [PDF]
Frontiers in Pharmacology, 2020 The P2X7 receptor (P2X7R) is an ATP-gated ion channel known for its proinflammatory activity. Despite its participation in host defense against pathogens, the role played in viral infections, notably those caused by herpes viruses, has been seldom ...
Anna Pegoraro +9 more
doaj +6 more sources
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition [PDF]
Frontiers in Immunology, 2021 The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat +5 more
doaj +6 more sources