Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]
Frontiers in Immunology, 2022 Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian +7 more
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High incidence and viral load of HHV-6A in a multi-centre kidney transplant cohort [PDF]
Frontiers in Transplantation, 2023 Human herpesvirus 6 (HHV-6) is a common opportunistic pathogen in kidney transplant recipients. Two distinct species of HHV-6, HHV-6A and HHV-6B, have been identified, of which the latter seems to be dominant. However, it is unclear whether they increase
Arturo Blazquez-Navarro +21 more
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Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani +11 more
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The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration. [PDF]
PLoS Pathogens, 2016 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types.
Nina Wallaschek +6 more
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DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]
Frontiers in Microbiology, 2020 ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti +11 more
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The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility [PDF]
Frontiers in Pharmacology, 2020 The P2X7 receptor (P2X7R) is an ATP-gated ion channel known for its proinflammatory activity. Despite its participation in host defense against pathogens, the role played in viral infections, notably those caused by herpes viruses, has been seldom ...
Anna Pegoraro +9 more
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HHV-6A infection induces amyloid-beta expression and activation of microglial cells [PDF]
Alzheimer’s Research & Therapy, 2019 Background The control of viral infections in the brain involves the activation of microglial cells, the macrophages of the brain that are constantly surveying the central nervous system, and the production of amyloid-beta (Aβ) as an anti-microbial ...
Daria Bortolotti +4 more
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HHV-6A Infection and Systemic Sclerosis: Clues of a Possible Association [PDF]
Microorganisms, 2019 Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, excessive extracellular matrix deposition, and fibrosis of the skin and internal organs.
Elisabetta Caselli +7 more
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Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A [PDF]
Frontiers in Microbiology, 2019 Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Anthony J. Saviola +12 more
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Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization. [PDF]
PLoS Pathogens, 2013 Human Herpesvirus 6 (HHV-6) is a ubiquitous virus with an estimated seroprevalence of 95% in the adult population. HHV-6 is associated with several neurologic disorders, including multiple sclerosis, an inflammatory demyelinating disease affecting the ...
Emily Leibovitch +11 more
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