HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B [PDF]
Viruses, 2017 Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of ...
Vanessa Collin, Louis Flamand
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Chromosomal integration of HHV-6A during non-productive viral infection [PDF]
Scientific Reports, 2017 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two different species of betaherpesviruses that integrate into sub-telomeric ends of human chromosomes, for which different prevalence rates of integration have been reported.
Nitish Gulve +3 more
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The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition [PDF]
Frontiers in Immunology, 2021 The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat +5 more
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HHV-6A Infection of Endometrial Epithelial Cells Induces Increased Endometrial NK Cell-Mediated Cytotoxicity [PDF]
Frontiers in Microbiology, 2017 Background: We have recently reported the presence of Human herpesvirus-6A (HHV-6A) DNA in the 43% of endometrial epithelial cells from primary idiopathic infertile women, with no positivity in fertile women.
Elisabetta Caselli +11 more
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Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility. [PDF]
PLoS ONE, 2016 To elucidate the roles of human herpesvirus (HHV)-6 primary unexplained infertile women, a prospective randomized study was conducted on a cohort of primary unexplained infertile women and a cohort of control women, with at least one successful pregnancy.
Roberto Marci +8 more
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Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders [PDF]
Frontiers in Microbiology, 2018 Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Bhupesh K. Prusty +11 more
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Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection [PDF]
Viruses, 2016 Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”.
Joshua Tweedy +5 more
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Impact of Host Telomere Length on HHV-6 Integration [PDF]
Viruses, 2022 Human herpesvirus 6A and 6B are two closely related viruses that infect almost all humans. In contrast to most herpesviruses, HHV-6A/B can integrate their genomes into the telomeres during the infection process.
Darren J. Wight +4 more
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Features of Human Herpesvirus-6A and -6B Entry [PDF]
Advances in Virology, 2012 Human herpesvirus-6 (HHV-6) is a T lymphotropic herpesvirus belonging to the Betaherpesvirinae subfamily. HHV-6 was long classified into variants A and B (HHV-6A and HHV-6B); however, recently, HHV-6A and HHV-6B were reclassified as different species ...
Takahiro Maeki, Yasuko Mori
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SARS-CoV-2 Infection Associated with HHV-6A Reactivation and an Inhibitory KIR2DL2/HLA-C1 Immunogenetic Profile [PDF]
MicroorganismsNatural killer (NK) cells are central to antiviral immunity through a balance of activating and inhibitory receptors, including killer immunoglobulin-like receptors (KIRs).
Sabrina Rizzo +8 more
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