Results 31 to 40 of about 4,464 (167)

Human Herpesvirus 6A Induces Dendritic Cell Death and HMGB1 Release without Virus Replication

Pathogens, 2021
Human herpesvirus 6A (HHV-6A) is a common virus that has important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity and are implicated in the pathogenesis of many human diseases, including infections.
Rasmus Gustafsson
doaj   +1 more source

HHV-6A Infection of Endometrial Epithelial Cells Affects miRNA Expression and Trophoblast Cell Attachment. [PDF]

Reprod Sci, 2020
AbstractWe recently reported that human herpesvirus 6 (HHV-6) infection is frequently present in endometrial tissue of women with unexplained infertility, and that virus infection induces a profound remodulation of miRNA expression in human cells of different origin.
Bortolotti D, Soffritti I, D'Accolti M, Gentili V, Di Luca D, Rizzo R, Caselli E.   +6 more
europepmc   +4 more sources

HHV-6A in Syncytial Giant-Cell Hepatitis

New England Journal of Medicine, 2008
Syncytial giant-cell hepatitis is a rare but severe form of hepatitis that is associated with autoimmune diseases, drug reactions, and viral infections. We used serologic, molecular, and immunohistochemical methods to search for an infectious cause in a case of syncytial giant-cell hepatitis that developed in a liver-transplant recipient who had latent
POTENZA, Leonardo, LUPPI, Mario, BAROZZI, Patrizia, ROSSI, Giulio, COCCHI, Stefania, Codeluppi, Mauro, Pecorari, Monica, MASETTI, Michele, DI BENEDETTO, Fabrizio, Gennari, William, PORTOLANI, Marinella, GERUNDA, Giorgio Enrico, LAZZAROTTO, TIZIANA, Landini, Maria Paola, Schulz, Thomas F., TORELLI, Giuseppe, GUARALDI, Giovanni   +16 more
openaire   +3 more sources

Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstrated by novel digital droplet PCR assay. [PDF]

PLoS ONE, 2014
The human herpesviruses HHV-6A and HHV-6B have been associated with various neurologic disorders partly due to the detection of elevated viral DNA levels in patients compared to controls.
Emily C Leibovitch, Giovanna S Brunetto, Breanna Caruso, Kaylan Fenton, Joan Ohayon, Daniel S Reich, Steven Jacobson   +6 more
doaj   +1 more source

The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells

Virus Research, 2022
HHV-6A is a neurotropic herpesvirus able to infect several CNS cells including astrocytes and primary neurons. Here we found that HHV-6A infection of astrocytoma cells, by reducing autophagy, increased ROS and induced ER stress, promoting the release of ...
Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Andrea Arena, Aurelia Gaeta, Mara Cirone   +5 more
doaj   +1 more source

Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte. [PDF]

Oncotarget, 2016
Human Herpesvirus 6 (HHV-6) has been involved in the development of several central nervous system (CNS) diseases, such as Alzheimer's disease, multiple sclerosis and glioma. In order to identify the pathogenic mechanism of HHV-6A infection, we carried out mRNA-seq study of human astrocyte HA1800 cell with HHV-6A GS infection.
Shao Q, Lin Z, Wu X, Tang J, Lu S, Feng D, Cheng C, Qing L, Yao K, Chen Y.   +9 more
europepmc   +4 more sources

Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease

The Scientific World Journal, 2013
Human herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease ...
Francesco Broccolo, Lisa Fusetti, Luca Ceccherini-Nelli   +2 more
doaj   +1 more source

Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins [PDF]

, 2015
Human herpesvirus-6A (HHV-6A) and HHV-6B integrate their genomes into the telomeres of human chromosomes, however, the mechanisms leading to integration remain unknown. HHV-6A/B encode a protein that has been proposed to be involved in integration termed
Collin, Vanessa, Dubuc, Isabelle, Flamand, Louis, Gilbert-Girard, Shella, Gravel, Annie, Kaufer, Benedikt B., Morissette, Guillaume, Trempe, Frédéric, Wallaschek, Nina   +8 more
core   +1 more source

Human herpesvirus 6A partially suppresses functional properties of DC without viral replication. [PDF]

PLoS ONE, 2013
Human herpesvirus 6A (HHV-6A) is a common virus with a worldwide distribution that has been associated with multiple sclerosis. Whether HHV-6A can replicate in dendritic cells (DC) and how the infection might modulate the functional properties of the ...
Rasmus K L Gustafsson, Elin E Engdahl, Oscar Hammarfjord, Sanjaya B Adikari, Magda Lourda, Jonas Klingström, Mattias Svensson, Anna Fogdell-Hahn   +7 more
doaj   +1 more source

Multiple sclerosis: an example of pathogenic viral interaction? [PDF]

, 2017
A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS ...
Walter Fierz
core   +1 more source