Results 1 to 10 of about 2,937 (141)

HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant [PDF]

Nature Communications
Limited understanding of the immunopathogenesis of human herpesvirus 6B (HHV-6B) has prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplant (HCT).
Joshua A. Hill, Yeon Joo Lee, Lisa K. Vande Vusse, Hu Xie, E. Lisa Chung, Alpana Waghmare, Guang-Shing Cheng, Haiying Zhu, Meei-Li Huang, Geoffrey R. Hill, Keith R. Jerome, Wendy M. Leisenring, Danielle M. Zerr, Sina A. Gharib, Sanjeet Dadwal, Michael Boeckh   +15 more
doaj   +4 more sources

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]

Frontiers in Immunology, 2022
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian, Elham Bahramian, Mercede Furr, Jerry T. Wu, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos   +7 more
doaj   +2 more sources

A Sensitive Quantification of HHV-6B by Real-time PCR [PDF]

Biological Procedures Online, 2002
Human herpesvirus (HHV)-6B is a pathogen causing latent infection in virtually all humans. Nevertheless, the interaction of HHV-6B with its host cells is poorly understood. Although HHV-6B is approximately 90% homologous to HHV-6A, it expresses certain B-
Øster Bodil, Höllsberg Per
doaj   +3 more sources

Characterization of the HHV-6B U20 Immunoevasin. [PDF]

J Virol, 2023
The roseolovirus U20 proteins are virus-encoded integral membrane glycoproteins possessing class I major histocompatibility complex (MHC)-like folds. Surprisingly, although U20 proteins from HHV-6A and -6B share 92% identity, recent studies ascribe different functions to HHV6A U20 and HHV6B U20.
Schneider CL, Whyte ML, Konrad SL, Hudson AW.   +3 more
europepmc   +3 more sources

Persistent viremia in an immunocompetent patient with inherited chromosomally integrated HHV-6B. [PDF]

Access Microbiol, 2021
Human herpesvirus-6 (HHV-6), the virus which causes roseola, has traditionally been associated with benign and self-limited childhood illness. However, HHV-6 establishes lifelong latency and can reactivate in immunocompromised adult patients. In about 1% of cases, it integrates into the human genome as inherited chromosomally integrated HHV-6 (iciHHV-6)
Obeid M, Gakhal I, McDonald PJ.
europepmc   +3 more sources

Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis [PDF]

Frontiers in Immunology
BackgroundHuman herpesvirus 6B (HHV-6B) is associated with various central nervous system (CNS) disorders, particularly in immunocompromised patients. We present a rare case of inherited chromosomally integrated HHV-6B (iciHHV-6B), also referred to as ...
Scott Sun, Scott Sun, Konstance Knox, Alexander Romashko, Madhu Kundu, Haiying Zhu, Meei-Li Huang, Denise M. Malicki, Denise M. Malicki, John R. Crawford, John R. Crawford, John R. Crawford   +11 more
doaj   +2 more sources

Evolutionary analysis of exogenous and integrated HHV-6A/HHV-6B populations. [PDF]

Virus Evol, 2020
AbstractHuman betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated HHV-6A/HHV-6B, iciHHV-6A/iciHHV-6B).
Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M.   +4 more
europepmc   +6 more sources

Oral brincidofovir decreases the incidence of HHV-6B viremia after allogeneic HCT. [PDF]

Blood, 2020
Abstract Human herpesvirus 6B (HHV-6B) frequently reactivates after allogeneic hematopoietic cell transplantation (HCT). There are no randomized studies of antiviral treatments to prevent HHV-6B reactivation. Brincidofovir has high in vitro activity against HHV-6B and other DNA viruses, but its in vivo activity for HHV-6B has not been ...
Hill JA, Nichols WG, Marty FM, Papanicolaou GA, Brundage TM, Lanier R, Zerr DM, Boeckh MJ.   +7 more
europepmc   +3 more sources

Role of HHV-6B Infection in Mesial Temporal Lobe Epilepsy. [PDF]

Pediatr Neurol Briefs, 2015
Investigators from Fujita Health University, Toyoake, and National Epilepsy Center, Shizuoka, Japan, studied the pathogenic role of HHV-6B in patients with mesial temporal lobe epilepsy (MTLE).
Millichap JJ, Millichap JG.
europepmc   +5 more sources

Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation. [PDF]

Open Forum Infect Dis
Abstract Background Human herpesvirus 6B (HHV-6B) frequently reactivates following allogeneic stem cell transplant (alloHCT). Consensus guidelines note that haploidentical alloHCT may represent a high-risk population for which there is little evidence; this warrants further investigation.
Handley G, Yepes A, Eliassen E, Dominguez G, Pasikhova Y, Klinkova O, Baluch A, Febres-Aldana AJ, Alsina M, Elmariah H, Khimani F, Hansen DK, Freeman CL, Jain MD, Locke F, Lazaryan A, Liu HD, Mishra A, Mirza AS, Nishihori T, Ochoa L, Perez L, Pidala J, Puglianini OC, Nieder M, Perna F, Kim J, Bejanyan N, Faramand R.   +28 more
europepmc   +3 more sources