Classification of HHV-6A and HHV-6B as distinct viruses. [PDF]
Arch Virol, 2014 Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-
Ablashi D +20 more
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DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]
Frontiers in Microbiology, 2020 ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti +11 more
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A complex evolutionary relationship between HHV-6A and HHV-6B.
Virus Evol, 2019 Human betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated HHV-6, iciHHV6). We reconstructed the population structure of HHV-6 and we show that HHV-6A genomes
Forni D +4 more
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Retraction to: A complex evolutionary relationship between HHV-6A and HHV-6B. [PDF]
Virus Evol, 2019 [This retracts the article DOI: 10.1093/ve/vez043.].
Forni D +4 more
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gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections. [PDF]
J Virol, 2020 Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and -6B entry into host cells.
Ma J +11 more
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The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation [PDF]
Frontiers in ImmunologyIntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) cells,
Grant C. Weaver +9 more
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Uncovering the Cause of Pneumonia: Reactivation of HHV-6B in an Immunocompromised Patient. [PDF]
Eur J Case Rep Intern MedHuman herpesvirus 6 (HHV-6) is a ubiquitous virus that commonly infects the paediatric population and establishes latency in the host following primary infection. As in other herpesviruses, HHV-6 may reactivate when the immune system becomes severely compromised, such as after chemotherapy or haematopoietic cell transplantation.
Rodrigues L +4 more
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HHV-6B induces IFN-lambda1 responses in cord plasmacytoid dendritic cells through TLR9.
PLoS ONE, 2012 Human herpesvirus type 6B (HHV-6B) is a strong inducer of IFN-alpha and has the capacity to promote Th1 responses and block Th2 responses in vitro. In this study we addressed whether inactivated HHV-6B can also induce IFN lambda responses and to what ...
Inger Nordström, Kristina Eriksson
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HHV-6B infection after umbilical cord blood stem cell transplantation with pruritus as the first symptom. [PDF]
Acta Biochim Biophys Sin (Shanghai), 2023 Xu B +8 more
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Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production [PDF]
Journal of VirologyHuman herpesvirus 6B (HHV-6B), a member of the Betaherpesvirinae subfamily, is a T-lymphotropic virus that causes exanthem subitum and has been implicated in neuroinflammatory conditions such as multiple sclerosis.
Haokun Li +5 more
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