Results 181 to 190 of about 78,371,982 (236)

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Valorization of post-distillation <i>Helichrysum italicum</i> biomass for functional beverage infusions. [PDF]

Food Chem X
Kenig S, Baruca Arbeiter A, Stupar A, Mišan A, Zugic A, Nešić I, Tadić V, Bandelj D, Jenko Pražnikar Z, Petelin A.   +9 more
europepmc   +1 more source

H‐Bonding‐Induced Repulsion Between Small Groups Toward a Highly Puckered Benzene

Advanced Science, EarlyView.
A benzene derivative bearing methylamino and nitro substituents adopts a boat‐shaped ring conformation. Comparison with four related compounds supports a role for intramolecular hydrogen bonding in constraining substituent orientations and promoting local steric crowding associated with ring puckering.
Chaofeng Zhao, Qi Sun, Ning Ding, Xiaoting Ren, Jinxuan He, Shenghua Li, Siping Pang   +6 more
wiley   +1 more source

NLRP3 Regulation in Neonatal Hypoxic-Ischemic Encephalopathy-Focus on Microglial Activation. [PDF]

Int J Mol Sci
Burkard H, Bernis ME, Bremer AS, Maes E, Walter J, Meissner F, Sabir H.   +6 more
europepmc   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Reductions in chronic pain cognitions and impact following intensive trauma and pain rehabilitation treatments: A case study. [PDF]

Psychol Trauma
Miller ML, Flegge LG, Wasson RS, Williams AE, Wakefield AE, Henderson DR, Bushey MA.   +6 more
europepmc   +1 more source

Synergistic Effects of Separator Architecture and Electrolyte Chemistry on the Electrochemical Stability of Lithium Ion Batteries With Li–Mn Rich Cathodes and µ‐Si Anodes

Advanced Science, EarlyView.
This work reveals that synergistic engineering of separator architecture and electrolyte chemistry determines the long‐term stability of LMR||µ‐Si cell chemistry. The introduction of N, N‐dimethylsulfamoyl fluoride (DMFSA) as a co‐solvent with fluoroethylene carbonate (FEC) promotes robust interphases on both electrodes, effectively mitigates side ...
Marian Cristian Stan, Bärbel Arling, Gerrit Michael Overhoff, Kirstin Darida, Lucas Marquart, Peng Yan, Lara Kersting, Linus Voigt, Laurin Profanter, Hyung‐Tae Kim, Martin Winter, Gunther Brunklaus, Isidora‐Cekic Laskovic   +12 more
wiley   +1 more source

Effects of Fetal Bovine Serum on Biofilm Formation and Cell Attachment of <i>Candida glabrata</i>. [PDF]

Microorganisms
Vecci BE, Deshpande SN, Baudin J, Kao KC.   +3 more
europepmc   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Annexin A6 in Eye-Lavage Extracellular Vesicles-a Candidate Biomarker for Sex-Specific Differences in Mild Hypoxic-Ischaemic Brain Damage-Findings from an Explorative Neonatal Mouse Model Study. [PDF]

Int J Mol Sci
Lange S, Needham SR, Kraev I, Davis BM, Hristova M.   +4 more
europepmc   +1 more source