Results 1 to 10 of about 254,858 (270)
HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning [PDF]
Drug Delivery, 2023 Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that were used as chemical warfare agents. HI-6 is one of the most promising reactivators which is effective in reactivating AChE inhibited by many nerve agents.
Liao Shen +5 more
doaj +2 more sources
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. [PDF]
Chem Biol Interact, 2016 The high toxicity of organophosphorus compounds originates from covalent inhibition of acetylcholinesterase (AChE), an essential enzyme in cholinergic neurotransmission. Poisonings that lead to life-threatening toxic manifestations require immediate treatment that combines administration of anticholinergic drugs and an aldoxime as a reactivator of AChE.
Maček Hrvat N +4 more
europepmc +7 more sources
Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6). [PDF]
Interdiscip Toxicol, 2013 ABSTRACT Sulfur mustard (SM) is a blister agent with cytotoxic mechanism of action. There is no suitable treatment based on administration of an antidote. In this study, Wistar rats were exposed to SM in doses of 0-40 mg/kg body weight and treated with the compound HI-6.
Pohanka M +3 more
europepmc +4 more sources
Neurobiology of Disease, 2021 The result of a deprivation of oxygen and glucose to the brain, hypoxic–ischemic encephalopathy (HIE), remains the most common cause of death and disability in human neonates globally and is mediated by glutamate toxicity and inflammation.
O. Arteaga Cabeza +9 more
doaj +1 more source
Evaluation of the neuroprotective efficacy of individual oxime (HI-6) and oxime mixtures (HI-6 + trimedoxime, HI-6 + K203) in tabun-poisoned rats [PDF]
Journal of Applied Biomedicine, 2009 The ability of the oxime HI-6 to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of two combinations of oximes (HI-6 + trimedoxime, HI-6 + K203) using a functional observational battery. Tabun-induced neurotoxicity and the neuroprotective effects of HI-6 alone, and HI-6 combined with trimedoxime ...
Jiří Kassa +2 more
openaire +1 more source
Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos [PDF]
Acta Veterinaria, 2012 The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos.
Antonijević Biljana +2 more
doaj +1 more source
Ibrain, 2022 This study aimed to investigate the role of interleukin‐6 (IL‐6) in the pathogenesis of neonatal hypoxic‐ischemic encephalopathy (NHIE). Sprague‐Dawley (SD) rats were used for the establishment of hypoxic‐ischemic (HI) model.
Xiu Yang +3 more
doaj +1 more source
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source
High spatial resolution mid-infrared observations of the low-mass young star TW Hya [PDF]
, 2007 We want to improve knowledge of the structure of the inner few AU of the circumstellar disk around the nearby T Tauri star TW Hya. Earlier studies have suggested the existence of a large inner hole, possibly caused by interactions with a growing ...
Bouwman, J. +5 more
core +4 more sources
Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice
Acta Medica, 2018 Aim: The influence of the dose on the ability of promising newly prepared reversible inhibitor of acetylcholinesterase (6-chlorotacrine) to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was ...
Jiří Kassa, Jan Korábečný
doaj +1 more source