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Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and function. [PDF]

Nat Commun
Richter M, Diesterbeck E, Pylaeva E, Labusek N, Köster C, Nagel D, Karsch L, Fischer AJ, Sous M, Jung M, Chevre R, Hagemann N, Andersson EA, Ek CJ, Singh V, Hermann DM, Gunzer M, Jablonska J, Felderhoff-Müser U, Bendix I, Soehnlein O, Herz J.   +21 more
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Genetic toxicology assessment of HI-6 dichloride

Environmental and Molecular Mutagenesis, 1996
The oxime HI-6 dichloride [1-(2 hydroxyiminomethyl -1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate] has shown to be a potent reactivator of cholinesterase activity and may have efficacy for the treatment of organophosphate intoxication [SIPRI, 1976; Schenk et al.; Arch Toxicol 36:71-81, 1976]. As part of a preclinical safety
D, Putman, R H, San, C A, Bigger, B S, Levine, D, Jacobson-Kram   +4 more
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A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats

Drug and Chemical Toxicology, 2011
The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime
Jiri, Kassa, Jana Zdarova, Karasova, Sandra, Tesarova   +2 more
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Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate

Archives of Toxicology, 2002
The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory.
S, Krummer, H, Thiermann, F, Worek, P, Eyer   +3 more
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Stability of HI-6 in Solution

Drug Development and Industrial Pharmacy, 1995
AbstractA stability-indicating reversed-phase high performance liquid chromatographic method was developed for the detection of HI-6 and its degradation products under accelerated degradation conditions. The degradation kinetics of HI-6 in aqueous solution over a pH range of 1.14 to 5.54 and its stability in propylene glycol or polyethylene glycol 400 ...
Da-Peng Wang, Jeng-Dong Lee, Rong-An Lin
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The pharmacokinetics of HI‐6 in beagle dogs

Biopharmaceutics & Drug Disposition, 1983
AbstractThe pharmacokinetics of HI‐6 were studied following intravenous administration to beagle dogs (n = 7). The bioavailability of two different strength intramuscularly administered doses was also determined in the same animals. After a 20 mg kg−1 intravenous dose, the mean (±S.D.) initial HI‐6 plasma concentration was 93·1 ± 10·μg ml−1.
K J, Simons, C J, Briggs
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Pharmacology of HI-6, an H-series oxime

Canadian Journal of Physiology and Pharmacology, 1989
HI-6 is an oxime experimentally developed for reactivation of previously untreatable soman-phosphorylated acetylcholinesterase. It has been shown to be effective in restoring acetylcholinesterase activity after poisoning with other "nerve agents" namely VX and sarin; however, its antidotal qualities for the treatment of organophosphorus pesticide ...
C G, Rousseaux, A K, Dua
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HI 6 dimethanesulfonate has better dissolution properties than HI 6 dichloride for application in dry/wet autoinjectors

International Journal of Pharmaceutics, 1996
To oppose the rapid onset of cholinergic crisis after poisoning with highly toxic organophosphorus compounds, atropine in combination with a cholinesterase reactivator should be administered as early as possible. Due to its broader antidotal spectrum against nerve agents, the second-generation oxime HI 6 appears suitable to replace the marketed oximes,
Horst Thiermann, Stephan Seidl, Peter Eyer   +2 more
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Non-reactivating effects of HI-6 on hippocampal neurotransmission

Archives of Toxicology, 1994
Effects of the oxime HI-6, unrelated to reactivation of acetylcholinesterase (AChE), on field potentials in the dentate gyrus of the rat hippocampus following AChE inhibition, were investigated both in vitro and in vivo. In hippocampal slices, AChE inhibition decreased the perforant path evoked population spike amplitude (PSA).
Melchers, B.P.C., Laaken, A.L. van der, Busker, R.W., Bruijnzeel, P.L.B., Helden, H.P.M. van   +4 more
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Cardiopulmonary effects of HI-6 treatment in soman intoxication

Journal of Applied Toxicology, 2001
The cardiopulmonary effects of HI-6, together with atropine and soman, were studied in the rat. HI-6 is an effective antidote in acute poisoning with the nerve agent soman. The therapeutic efficiency of HI-6 is still unclear and cannot be explained entirely by the HI-6 reactivating ability of acetylcholinesterase (AChE).
A, Göransson-Nyberg, G, Cassel
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