Results 241 to 250 of about 254,858 (270)

DFT conformational studies of the HI‐6 molecule

International Journal of Quantum Chemistry, 2005
AbstractA systematic study of the oxime HI‐6 [1‐(2‐hydroxyiminomethyl‐1‐pyridinium)‐1‐(4‐carboxy‐aminopyridinium)dimethyl ether] hydrochloride, which is one of the most promising antidotes against soman intoxication, was carried out using density functional theory with the B3LYP (Becke, Lee, Yang, and Parr) method and the 6‐31+G*, 6‐31+G*, and 6‐31+G**
Gustavo R. Silva, Itamar Borges, Jose D. Figueroa‐Villar   +2 more
openaire   +1 more source

Bioavailability and disposition kinetics of HI‐6 in Beagle dogs

Biopharmaceutics & Drug Disposition, 1993
AbstractThe absorption and disposition kinetics of HI‐6 were determined in Beagle dogs given single doses (25 mg kg−1) of the drug by the intravenous, intramuscular, and oral routes. Concentrations of the oxime in plasma and urine were measured by HPLC.
J D, Baggot, A, Buckpitt, D, Johnson, P, Brennan, H, Chung   +4 more
openaire   +2 more sources

Photostability of antidotal oxime HI‐6, impact on drug development

Drug Testing and Analysis, 2012
HI‐6 exhibits superior efficacy in the therapy of intoxication by different highly toxic organophosphorus nerve agents. Therefore HI‐6 is a promising candidate for the development of new antidotes against nerve agents. For ethical and safety reasons antidotes containing HI‐6 should get marketing authorization.
Reinhard, Bogan, Franz, Worek, Marianne, Koller, Bernd, Klaubert   +3 more
openaire   +2 more sources

Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys

Toxicology and Applied Pharmacology, 1992
The therapeutic efficacy of the oxime HI-6 against intoxication with the irreversible cholinesterase (ChE) inhibitor soman was tested in marmoset monkeys. Five out of six marmosets, intoxicated with 5 x LD50 soman and treated immediately with diazepam (0.2 mg.kg-1 iv) and 15 sec later with atropine (0.5 mg.kg-1 im) and HI-6 (50 mg.kg-1 im), survived ...
H P, van Helden, H J, van der Wiel, J, de Lange, R W, Busker, B P, Melchers, O L, Wolthuis   +5 more
openaire   +2 more sources

Neurobehavioral effects of the pyridinium aldoxime cholinesterase reactivator HI-6

Neurotoxicology and Teratology, 1990
A series of neurobehavioral testing procedures was used to evaluate the behavioral effects of the pyridinium aldoxime cholinesterase reactivator HI-6 in male Sprague-Dawley rats. These procedures were fixed-ratio (FR) responding, shuttle-box conditioned avoidance response (CAR), conditioned taste aversion (CTA), drinking behavior, open-field ...
W F, Liu, J H, Shih
openaire   +2 more sources

HI-6 Therapy and the acute phase response in the rat

Toxicology, 1996
The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma ...
S, Ivanović-Matić, G, Poznanović
openaire   +2 more sources

Trimedoxime and HI‐6: Kinetic Comparison after Intravenous Administration to Mice

Pharmacology & Toxicology, 1996
Abstract: The intravenous pharmacokinetics of the oximes HI‐6 (pyridinium‐1‐(((4‐carbamoi 1‐pyridinio)metoxy)rnethyl)‐2‐(hydroxyiminomethyl)dichloride monohydrate), (132.54 μmol/kg) and trimedoxime (1,1′‐(1,3′‐propanedyl)bis((4‐hydroxyimino) methyl)‐pyridinium dibromide), (55,98 μmol/kg) in mice was investigated. The concentrations of oximes in plasma
B, Milic, M, Maksimovic, M, Nedelijkovic
openaire   +2 more sources

Cholinergic Effects of HI-6 in Soman Poisoning

1986
During the past decade considerable advances have been made in the development of therapeutic antidotes against organophosphorus cholinesterase (ChE) inhibitors. Poisoning with most organophosphorus anticholinesterases (AntiChE) is treatable with a combination of an antimuscarinic compound, such as atropine sulfate (ATS), and an oxime, such as ...
T.-M. Shih, C. E. Whalley, J. J. Valdes, P. M. Lundy, P. A. Lockwood   +4 more
openaire   +1 more source

The acetylcholinesterase reactivator HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxylmethyl]-2-[(hydroxyimino)methyl]-pyridinium dichloride): a comparative study of HI-6 samples from various sources

Archives of Toxicology, 1988
A comparison of the chemical purity, toxicology and potency of HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2- [(hydroxyimino)methyl]-pyridinium dichloride) obtained from various sources (Canada, Israel, Yugoslavia, The Netherlands, United Kingdom) was performed.
J G, Clement, P A, Lockwood, H G, Thompson   +2 more
openaire   +2 more sources

Study on the stability of the oxime HI 6 in aqueous solution

Archives of Toxicology, 1988
HI 6 (Pyridinium, 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydro xyimino) methyl]-dichloride is an effective antidote against poisoning with extremely toxic organophosphates. Because of conflicting reports on the stability of HI 6 in aqueous solutions, we studied the factors influencing its stability. HI 6 has been shown to be most stable in
P, Eyer, I, Hagedorn, B, Ladstetter
openaire   +2 more sources