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Application of interspecies scaling to the bispyridinium oxime HI-6
American Journal of Veterinary Research, 1994Summary Disposition kinetic variables of HI-6, a bispyridinium oxime, have been determined in mice, rats, rabbits, Rhesus monkeys, Beagles, sheep, and human beings. The drug has a short half-life, small apparent volume of distribution and high body clearance in these species, and is eliminated mainly by renal excretion.
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Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP
Biochemical and Biophysical Research Communications, 2006We used mouse recombinant wild-type acetylcholinesterase (AChE; EC 3.1.1.7), butyrylcholinesterase (BChE; EC 3.1.1.8), and AChE mutants with mutations (Y337A, F295L, F297I, Y72N, Y124Q, and W286A) that resemble residues found at structurally equivalent positions in BChE, to find the basis for divergence between AChE and BChE in following reactions ...
Kovarik, Zrinka +4 more
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Studies on the decomposition of the oxime HI 6 in aqueous solution
Archives of Toxicology, 1986HI 6 has been shown to be efficacious in soman intoxication of laboratory animals by reactivation of acetylcholinesterase. To assess possible risks involved in the administration of HI 6 its degradation products were analyzed at pH 2.0, 4.0, 7.4, and 9.0.
P, Eyer, W, Hell, A, Kawan, H, Klehr
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A High-Performance Liquid Chromatographic Assay for HI-6 Oxime in Plasma*
Journal of Analytical Toxicology, 1990A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 (1-(2-hydroxyiminomethyl-1-pyridinio-3-(4-carbamoyl-1-py ridiniol-2-oxapropane dichloride)) concentrations in small volumes of plasma. A 100-microL plasma sample added to 900 microL of distilled water was microfiltered. Filtrate (200 microL) was injected onto an HPLC
M P, McCluskey +4 more
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In vitro and in vivo genotoxicity assessment of HI-6 dimethanesulfonate/oxime
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014Organophosphate compounds, which induce organophosphate poisoning, were originally used as pesticides. But this type of product has also been used as warfare nerve agent like sarin, soman, Russian VX, or tabun. HI-6-dimethanesulfonate is a salt of the oxime HI-6 used in the treatment of nerve-agent poisoning.
Lauren, Nakab +5 more
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HI-6 therapy of soman and tabun poisoning in primates and rodents
Archives of Toxicology, 1989The bis-pyridinium oxime HI-6, in conjunction with atropine, was found to offer significant protection against multiple LD50 challenges with the organophosphorus compounds soman and tabun. In adult rhesus macaques, the therapeutic administration of HI-6 with atropine and diazepam protected three of four animals from the lethal effects of 5 x LD50 of ...
M G, Hamilton, P M, Lundy
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Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime
Biochemical Pharmacology, 1986Acetylcholinesterase was purified from human caudate nucleus and skeletal muscle. The enzyme preparations were used to study aging and reactivation by HI-6 and obidoxime after inhibition by soman and its isomers. HI-6 was found to be the most potent reactivator.
G, Puu, E, Artursson, G, Bucht
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HI-6 modulates immunization efficacy in a BALB/c mouse model
Environmental Toxicology and Pharmacology, 2013HI-6 is used as an antidote to nerve agents. It can also act as an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α 7 nAChR which is involved in regulating the immune response through macrophages. This experiment investigated the efficacy of HI-6 to regulate the immune response.
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Toxicology, 2016
Despite extensive research for decades no effective broad-spectrum oxime for the treatment of poisoning by a broad range of nerve agents is available. Previous in vitro and in vivo data indicate that the combination of in service oximes could be beneficial.
Franz, Worek +3 more
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Despite extensive research for decades no effective broad-spectrum oxime for the treatment of poisoning by a broad range of nerve agents is available. Previous in vitro and in vivo data indicate that the combination of in service oximes could be beneficial.
Franz, Worek +3 more
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An optical biosensor based on His 6 -OPH for organophosphate detection
SPIE Proceedings, 2011In this work we describe a method for immobilizing the hexahistidine-modified OPH (His 6 -OPH) enzyme via sol-gel technology in a porous material while retaining its catalytic activity. The potential use of each bio-sensing material was checked by quantifying the enzymatic properties, such as the relative activity of the immobilized enzyme, its ...
Nina Frančič +4 more
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