Results 261 to 270 of about 254,858 (270)

Effect of endogenous carboxylesterase on HI-6 protection against soman toxicity.

The Journal of Pharmacology and Experimental Therapeutics, 1990
Species variation in oxime protection against soman was examined in mice and guinea pigs with the bis-pyridinium oxime HI-6. HI-6, an effective reactivator of soman-inhibited acetylcholinesterase, produced greater maximal protection against soman in mice than in guinea pigs, although there was no species difference in acetylcholinesterase reactivation.
D M, Maxwell, I, Koplovitz
openaire   +2 more sources

HI-6 is Incapable of Reactivating Tabun-Phosphonylated Human Acetylcholinesterase

1995
A 1:10 (w/v) ratio of human brain homogenate in phosphate buffer (67 mmol-L−1, pH 7.2) was respectively added to sarin or VX (50 nmol-L−1), tabun or soman (100 nmol-L−1). A 1:60 (v/v) ratio of human RBC suspension in isotonic phosphate buffer (pH 7.2) was added to nerve agents (all 87 nmol-L−1).
Chunyuan Luo, Jinsheng Yang, Manji Sun
openaire   +1 more source

Chemical Stability of the Hagedorn Oximes HGG‐12 and HI‐6

Archiv der Pharmazie, 1985
AbstractThe chemical stability of the soman antidotes HGG‐12 and HI‐6 was studied over the pH range 2–9 at various temperatures. Maximum stability for both oximes was found at pH 2. From Arrhenius plots the predicted shelf life (10% decomposition) was 2.6 years at 25° C and 60 years at 4 °C for both oximes.
Peter Eyer, Winfried Hell
openaire   +1 more source

HI-6 in Man: Efficacy of the Oxime in Poisoning by Organophosphorus Insecticides

Human & Experimental Toxicology, 1991
The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d.
R, Kusić, D, Jovanović, S, Randjelović, D, Joksović, V, Todorovic, B, Bosković, M, Jokanović, V, Vojvodić   +7 more
openaire   +2 more sources

Histopathological Changes in Gastrocnemius Muscles of Rabbits Injected with HI-6 in Saline

Drug and Chemical Toxicology, 1990
The gastrocnemius muscles of rabbits were injected with HI-6 in saline. Macroscopic and histopathological examinations of injection sites and regional lymph nodes revealed that HI-6 in saline produced muscle necrosis. Macroscopic examinations of muscles injected with a low dose of HI-6 (50 mg/kg) showed no lesions on Day 7.
C E, Connolley-Mendoza, T, Bhatti, K, Jericho   +2 more
openaire   +2 more sources

Hyaluronidase: Its effects on HI-6 dichloride and dimethanesulphonate pharmacokinetic profile in pigs

Toxicology Letters, 2013
Pigs were administered intramuscularly molar equivalents of HI-6 salts (HI-6 dichloride 10.71 mg/kg and HI-6 DMS 13.59 mg/kg) either with or without hyaluronidase (60 U/kg). Hyaluronidase is supposed to increase tissue permeability and diminishes discomfort caused by the intramuscular injection.
Jana Zdarova, Karasova, Michal, Pavlik, Jaroslav, Chladek, Daniel, Jun, Kamil, Kuca   +4 more
openaire   +2 more sources

Stability study of HI-6 dichloride in various anticholinergic formulations

Journal of Chromatography A, 1984
N D, Brown, R R, Gray, M G, Stermer-Cox, B P, Doctor, I, Hagedorn   +4 more
openaire   +2 more sources

Inhibicija acetilkolinesteraze i butirilkolinesteraze piridinijevim oksimima 2- PAM i HI-6

2005
Piridin-2-aldoksim-N-metilklorid (2-PAM) i 1- (2-hidroksiiminometil-1-piridinio)-3-(4- karbamoil-1-piridinio)-2-oksapropan diklorid (HI-6) su reverzibilni inhibitori acetilkolinesteraze (EC 3.1.1.7 ; AChE) i butirilkolinesteraze (EC 3.1.1.8 ; BChE).
openaire   +1 more source

TORQUATO TASSO, in his 6 Part., fol. 47

1940
openaire   +1 more source

Torquato Tasso. in his 6 Part. fol. 47

openaire   +1 more source