Genetic Progression of High Grade Prostatic Intraepithelial Neoplasia to Prostate Cancer [PDF]
European Urology, 2016 Although high grade prostatic intraepithelial neoplasia (HGPIN) is considered a neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN remain unknown.Identification of the genomic landscape of HGPIN and the genomic differences between HGPIN and PCA that may drive the progression to PCA.We analyzed 20 regions of paired ...
Jung, Seung-Hyun +8 more
openaire +2 more sources
Health Science Journal of Indonesia, 2020 Latar Belakang: Gangguan regulasi mikroRNA(miR) dan inflamasi kronik dapat mengubah tumor menjadi karsinoma dan kanker dengan metastasis melalui perubahan seluler dan genomik. Lesi prekanker memiliki peluang 33,3 persen menjadi kanker.
Rachma Greta Putri +6 more
doaj +1 more source
Recurrent prostatic stromal sarcoma with massive high-grade prostatic intraepithelial neoplasia [PDF]
Journal of Clinical Pathology, 2007 A unique case of prostatic stromal sarcoma (PSS) that recurred in the pelvic cavity with massive high-grade prostatic intraepithelial neoplasia is described. A 52-year-old man who presented with urinary retention underwent a radical cystoprostatectomy.
Teppei, Morikawa +6 more
openaire +2 more sources
CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy [PDF]
, 2014 Despite the high incidence and mortality of prostate cancer, the etiology of this disease is not fully understood. In this study, we develop functional evidence for CBP and PTEN interaction in prostate cancer based on findings of their correlate ...
Chen, Shuai +15 more
core +1 more source
Journal of the Egyptian National Cancer Institute, 2014 Background: Histopathological differentiation between BCH and HGPIN in prostatic needle biopsies is a diagnostic challenge. The gold standard for detection of HGPIN and BCH is histopathological examination; however subjectivity in interpretation and tiny
Fatma El-Zahraa Salah El-Deen Yassin +4 more
doaj +1 more source
ZEB1 is Negatively Correlated with E-Cadherin in Prostatic Anomaly Tissue
MCBS (Molecular and Cellular Biomedical Sciences), 2022 Background: Prostatic anomalies are common in tumor or infection condition. The enlargement of prostate gland affects the epithelial cell polarity that involves epithelial-mesenchymal transition (EMT).
Sari Eka Pratiwi +7 more
doaj +1 more source
Androgen receptors beyond prostate cancer: an old marker as a new target. [PDF]
, 2014 Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy.
Kurzrock, Razelle +2 more
core +2 more sources
Tailored for Real-World: A Whole Slide Image Classification System Validated on Uncurated Multi-Site Data Emulating the Prospective Pathology Workload. [PDF]
, 2020 Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin & eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher efficiency and ...
Ayyagari, Devi +11 more
core +1 more source
PSA and anthropometric measurements among Amazon Indians: an evaluation of the Parkatejê community [PDF]
, 2003 OBJECTIVE: PSA (prostate-specific antigen) screening for early detection of prostate cancer in a native community is of great epidemiological importance.
Arruda, Homero Oliveira de [UNIFESP] +3 more
core +1 more source
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer [PDF]
, 2013 Histone variants seem to play a major role in gene expression regulation. In prostate cancer, H2A.Z and its acetylated form are implicated in oncogenes’ upregulation.
Amado, Francisco +8 more
core +2 more sources