Results 61 to 70 of about 18,903,414 (298)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Cell Wall Porosity in Norway Spruce Wood as Affected by High-Temperature Drying [PDF]

, 2011
In this study, pore size distribution in wood after high-temperature drying followed by rewetting was investigated by differential scanning calorimetry. Nonfreezing water content of wood was lower than previously indicated considering the effect of phase
Borrega, Marc, Kärenlampi, Petri P.
core   +3 more sources

Numerical Study on the Variable-Temperature Drying and Rehydration of Shiitake

Foods
Variable-temperature convective drying (VTCD) is a promising technology for obtaining high-quality dried mushrooms, particularly when considering rehydration capacity.
Lizhe Zhang, Long Jiang, Meriem Adnouni, Sheng Li, Xuejun Zhang   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

MODEL LAJU PENGERINGAN SPAGHETTI JAGUNG MENGGUNAKAN TRAY DRIER [Drying Model of Corn Spaghetti using Tray Drier]

Jurnal Teknologi dan Industri Pangan, 2015
Drying is the most crucial process that determines the final quality of pasta products. Drying at high temperature has been widely used; however, it may cause texture damage in the form of cracking in the product.
Tjahja Muhandri, Gina Nur Rahmasari, Subarna, Purwiyatno Hariyadi   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

One-Dimensional NMR Imaging of High-Temperature First-Drying in Monolithics [PDF]

Applied Magnetic Resonance, 2018
In this study a specialized high-temperature nuclear magnetic resonance (NMR) setup is presented for measuring free moisture in monolithic refractory castables during one-sided heating (100-300 °C). This setup makes use of a high thermal-stability Birdcage-coil for measuring the quantitative moisture content at high-temperatures, while also utilizing a
Barakat, A.J., Pel, L., Adan, O.C.G.
openaire   +4 more sources

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

ALTERNATING DIRECTION IMPLICIT METHOD FOR SOLVING EQUATIONS OF 2-D HETEROGENEOUS MODEL OF DEEP-BED GRAIN DRYING [PDF]

, 2000
In this paper, numerical studies of two-dimensional mathematical model are presented for deep-bed grain drying based on heat and mass transfer. The two-dimensional dynamic equations are solved numerically by finite difference method with alternating ...
Istadi, I., Sitompul, J.P
core   +1 more source