Results 1 to 10 of about 1,151,444 (131)
SLAS Technology, 2023 Laboratory automation uses large amounts of plastic consumables, generating substantial single-use plastic waste. Automated ELISAs are an indispensable analytical tool in vaccine formulation and process development.
Brittney Pedrazzi +7 more
doaj +1 more source
A perspective on the discovery of enzyme activators
SLAS Discovery, 2022 Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville +4 more
doaj +1 more source
EndoBind detects endogenous protein-protein interactions in real time
Communications Biology, 2021 Bill et al describe two high-throughput methods to detect protein-protein interactions in cells in real-time using the split-NanoLuciferase-complementation system.
Anke Bill +12 more
doaj +1 more source
Navigating the Landscape: A Comprehensive Review of Current Virus Databases
Viruses, 2023 Viruses are abundant and diverse entities that have important roles in public health, ecology, and agriculture. The identification and surveillance of viruses rely on an understanding of their genome organization, sequences, and replication strategy ...
Muriel Ritsch +3 more
doaj +1 more source
High throughput spatial convolution filters on FPGAs [PDF]
, 2020 Digital signal processing (DSP) on field- programmable gate arrays (FPGAs) has long been appealing because of the inherent parallelism in these computations that can be easily exploited to accelerate such algorithms.
Al-Dujaili, Abdullah +2 more
core +1 more source
Decoding cell-type contributions to the cfRNA transcriptomic landscape of liver cancer
Human Genomics, 2023 Background Liquid biopsy, particularly cell-free RNA (cfRNA), has emerged as a promising non-invasive diagnostic tool for various diseases, including cancer, due to its accessibility and the wealth of information it provides.
Aram Safrastyan +2 more
doaj +1 more source
High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ
SLAS Discovery, 2023 The cellular thermal shift assay (CETSA®) has increasingly been used in early drug discovery to provide a measure of cellular target engagement. Traditionally, CETSA has been employed for bespoke questions with small to medium throughput and has ...
Hannah Rowlands +9 more
doaj +1 more source
High throughput accelerator interface framework for a linear time-multiplexed FPGA overlay [PDF]
, 2020 Coarse-grained FPGA overlays improve design productivity through software-like programmability and fast compilation. However, the effectiveness of overlays as accelerators is dependent on suitable interface and programming integration into a typically ...
Fahmy, Suhaib A. +4 more
core +1 more source
A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa
Microbiology Spectrum, 2022 Pseudomonas aeruginosa is an opportunistic pathogen that has been declared by the World Health Organization as a “priority 1 critical pathogen” needing immediate new strategies for chemotherapy. During infection, P.
Mamie Kannon +5 more
doaj +1 more source
SLAS Discovery, 2022 Rapid triage of compounds acting via undesired mechanisms is a crucial stage in a high-throughput screening (HTS) cascade to ensure time and resource is efficiently assigned to the most propitious hits.
Rachel Moore +4 more
doaj +1 more source