Results 61 to 70 of about 238,699 (232)

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Diagnostic applications of next generation sequencing: working towards quality standards [PDF]

, 2012
Over the past 6 years, next generation sequencing (NGS) has been established as a valuable high-throughput method for research in molecular genetics and has successfully been employed in the identification of rare and common genetic variations. All major
Adey, Andrea Gehring, Anna Benet-Pagès, Bainbridge, Bentley, Carsten Bergmann, Clark, Clement, Ding, Dohm, Gerlinger, Gregory, Greif, Greif, Hanno Jörn Bolz, Hanns-Georg Klein, Harismendy, Ina Vogl, Jiang, Johansson, Kaimo Hirv, Kalari, Klaus H. Metzeler, Koboldt, Li, Lister, Loman, Mamanova, Manfred Stuhrmann, Mardis, Marius Kuhn, Mertes, Meyerson, Minoche, Nakamura, Philipp A. Greif, Robinson, Rothberg, Saskia Biskup, Sebastian H. Eck, Shendure, Stefan Kotschote, Stratton   +42 more
core   +1 more source

Additional file 3 of Correcting nucleotide-specific biases in high-throughput sequencing data

, 2017
Figure S2. ChIP-seq and DNase-seq coverage in a super enhancer region (Hnisz D, Abraham BJ, Lee TI, et al. Transcriptional super-enhancers connected to cell identity and disease. Cell. 2013;155(4):10.1016/j.cell.2013.09.053). This region is also in a DNase hypersensitivity region.
Wang, Jeremy, Quach, Bryan, Furey, Terrence   +2 more
openaire   +1 more source

Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle [PDF]

, 2015
Background Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus.
A Achilli, A Achilli, A Esteve-Codina, A Gotherstrom, A Seguin-Orlando, A Vaysse, A Winter, AE Minoche, AJ Amaral, Alison Murphy, Amanda J. Lohan, Andrew T. Chamberlain, AV Zimin, B Grisart, B Grisart, BP Lewis, Brendan J. Loftus, C Gamba, C Glaser, Ceiridwen J. Edwards, CG Elsik, Charles Spillane, CJ Edwards, CJ Edwards, CJ Edwards, CJ Rubin, CJ Stevens, CM Leu, CS Troy, D Reich, Daniel G. Bradley, David A. Magee, David E. MacHugh, DE MacHugh, DG Bradley, DM Larkin, DP Toews, E Palkopoulou, E Svensson, EJ McTavish, EY Durand, H Jonsson, H Jonsson, H Li, H Zhang, HD Daetwyler, J Clutton-Brock, J Diamond, J Kantanen, J Lenstra, J Schibler, JA Guerra-Assuncao, JD Vigne, JE Decker, JK Pickrell, JK Pritchard, JS Pedersen, K Prufer, KA Moutou, Kévin Rue-Albrecht, L Orlando, L Perez-Pardal, LK Matukumalli, M Gautier, M Hofreiter, M Li, M Meyer, M Raghavan, M Rasmussen, M Schubert, MA DePristo, MA Greagg, MA Groenen, Mark T. Donoghue, Martin Braud, Matthew D. Teasdale, MJ Montague, N Murakami, N Patterson, NA Rosenberg, O Smith, Paul A. McGettigan, R Bollongino, R Chen, RA Gibbs, RE Green, RE Green, RH Meadow, RR Hudson, RT Loftus, S Bonfiglio, S Bonfiglio, S Bonfiglio, S Guindon, S Koks, S Paabo, S Qanbari, S Sawyer, Shuaishuai Tai, Stephen D E Park, Steven Schroeder, Tad S. Sonstegard, TH Lee, W McLaren, Y Benjamini, Yuan Liu   +105 more
core   +1 more source

Brief Report: High‐Throughput Sequencing of IL23R Reveals a Low‐Frequency, Nonsynonymous Single‐Nucleotide Polymorphism That Is Associated With Ankylosing Spondylitis in a Han Chinese Population [PDF]

Arthritis & Rheumatism, 2013
ObjectiveAnkylosing spondylitis (AS) is a highly heritable common inflammatory arthritis that targets the spine and sacroiliac joints of the pelvis, causing pain and stiffness and leading eventually to joint fusion. Although previous studies have shown a strong association of IL23R with AS in white Europeans, similar studies in East Asian populations ...
Stuart I, Davidson, Lei, Jiang, Adrian, Cortes, Xin, Wu, Evgeny A, Glazov, Marina, Donskoi, Yi, Zheng, Patrick A, Danoy, Yi, Liu, Gethin P, Thomas, Matthew A, Brown, Huji, Xu   +11 more
openaire   +4 more sources

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

Advanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe, Jacobus Burger, Jamie Jones, Apurva Panjla, William L. Murphy   +4 more
wiley   +1 more source

Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme. [PDF]

, 2020
Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and its
Andreasson, Johan OL, Block, Steven M, Greenleaf, William J, Savinov, Andrew   +3 more
core  

A saturated genetic linkage map of autotetraploid alfalfa (Medicago sativa L.) developed using genotyping-by-sequencing is highly syntenous with the Medicago truncatula genome. [PDF]

, 2014
A genetic linkage map is a valuable tool for quantitative trait locus mapping, map-based gene cloning, comparative mapping, and whole-genome assembly. Alfalfa, one of the most important forage crops in the world, is autotetraploid, allogamous, and highly
Acharya, Ananta, Brummer, E Charles, Jiang, Qingzhen, Kang, Junmei, Li, Xuehui, Wei, Yanling   +5 more
core   +2 more sources

Additional file 1 of Correcting nucleotide-specific biases in high-throughput sequencing data

, 2017
Figure S1. GM12878 DNase-seq 5-mer tile covariance matrix. The pairwise correlation is shown between bias values of 5-mer tiles in a 160bp window surrounding the 5â end of aligned reads. The block structure between tiles 0 and 3 indicates correlation between adjacent k-mer frequencies within DNase-seq reads. (PDF 203 kb)
Wang, Jeremy, Quach, Bryan, Furey, Terrence   +2 more
openaire   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source