Results 1 to 10 of about 485,334 (314)
High-throughput screening of encapsulated islets using wide-field lens-free on-chip imaging [PDF]
, 2018 Islet microencapsulation is a promising solution to diabetes treatment, but its quality control based on manual microscopic inspection is extremely low-throughput, highly variable and laborious.
Alexander, Michael +6 more
core +3 more sources
A perspective on the discovery of enzyme activators
SLAS Discovery, 2022 Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville +4 more
doaj +1 more source
High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ
SLAS Discovery, 2023 The cellular thermal shift assay (CETSA®) has increasingly been used in early drug discovery to provide a measure of cellular target engagement. Traditionally, CETSA has been employed for bespoke questions with small to medium throughput and has ...
Hannah Rowlands +9 more
doaj +1 more source
A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa
Microbiology Spectrum, 2022 Pseudomonas aeruginosa is an opportunistic pathogen that has been declared by the World Health Organization as a “priority 1 critical pathogen” needing immediate new strategies for chemotherapy. During infection, P.
Mamie Kannon +5 more
doaj +1 more source
EndoBind detects endogenous protein-protein interactions in real time
Communications Biology, 2021 Bill et al describe two high-throughput methods to detect protein-protein interactions in cells in real-time using the split-NanoLuciferase-complementation system.
Anke Bill +12 more
doaj +1 more source
SLAS Discovery, 2022 Rapid triage of compounds acting via undesired mechanisms is a crucial stage in a high-throughput screening (HTS) cascade to ensure time and resource is efficiently assigned to the most propitious hits.
Rachel Moore +4 more
doaj +1 more source
High-throughput detection of metal contamination in HTS outputs
SLAS Discovery, 2022 Large compound libraries utilised for HTS often include metal contaminated compounds which can interfere with assay signal or target biology, and therefore appear as hits.
Corinne Molyneux +5 more
doaj +1 more source
Nature Communications, 2021 Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post ...
Boning Niu +9 more
doaj +1 more source
Advancing liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry toward ultra-high-throughput analysis [PDF]
, 2020 Label-free high-throughput screening using mass spectrometry has the potential to provide rapid large-scale sample analysis at a speed of more than one sample per second.
Brown, Jeffery +5 more
core +1 more source