Results 1 to 10 of about 1,236,846 (314)
A perspective on the discovery of enzyme activators
SLAS Discovery, 2022 Enzyme activation remains a largely under-represented and poorly exploited area of drug discovery despite some key literature examples of the successful application of enzyme activators by various mechanisms and their importance in a wide range of ...
Antonia Turberville +4 more
doaj +1 more source
High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ
SLAS Discovery, 2023 The cellular thermal shift assay (CETSA®) has increasingly been used in early drug discovery to provide a measure of cellular target engagement. Traditionally, CETSA has been employed for bespoke questions with small to medium throughput and has ...
Hannah Rowlands +9 more
doaj +1 more source
A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa
Microbiology Spectrum, 2022 Pseudomonas aeruginosa is an opportunistic pathogen that has been declared by the World Health Organization as a “priority 1 critical pathogen” needing immediate new strategies for chemotherapy. During infection, P.
Mamie Kannon +5 more
doaj +1 more source
EndoBind detects endogenous protein-protein interactions in real time
Communications Biology, 2021 Bill et al describe two high-throughput methods to detect protein-protein interactions in cells in real-time using the split-NanoLuciferase-complementation system.
Anke Bill +12 more
doaj +1 more source
High-throughput screening of 2D van der Waals crystals with plastic deformability
Nature Communications, 2022 Inorganic semiconductors exhibit multifarious physical properties, but they are prevailingly brittle, impeding their application in flexible and hetero-shaped electronics.
Zhiqian Gao +7 more
semanticscholar +1 more source
SLAS Discovery, 2022 Rapid triage of compounds acting via undesired mechanisms is a crucial stage in a high-throughput screening (HTS) cascade to ensure time and resource is efficiently assigned to the most propitious hits.
Rachel Moore +4 more
doaj +1 more source
Chemical Reviews, 2021 Transition-metal complexes are attractive targets for the design of catalysts and functional materials. The behavior of the metal-organic bond, while very tunable for achieving target properties, is challenging to predict and necessitates searching a ...
Aditya Nandy +5 more
semanticscholar +1 more source
High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases
Bioengineering, 2021 Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in progressive degeneration and/or death of nerve cells in the central nervous system (CNS).
H. Aldewachi +3 more
semanticscholar +1 more source
High-throughput detection of metal contamination in HTS outputs
SLAS Discovery, 2022 Large compound libraries utilised for HTS often include metal contaminated compounds which can interfere with assay signal or target biology, and therefore appear as hits.
Corinne Molyneux +5 more
doaj +1 more source
Molecular docking-based computational platform for high-throughput virtual screening
CCF Transactions on High Performance Computing, 2022 Structure-based virtual screening is a key, routine computational method in computer-aided drug design. Such screening can be used to identify potentially highly active compounds, to speed up the progress of novel drug design.
Baohua Zhang +3 more
semanticscholar +1 more source