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High-throughput in vivo vertebrate screening [PDF]
Nature Methods, 2010 We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and genetic screens on zebrafish larvae. The system automatically loads zebrafish from reservoirs or multiwell plates, and positions and rotates them for high-speed confocal imaging and laser manipulation of both superficial and deep organs within 19 s without damage. We
Pardo-Martin, Carlos +5 more
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High-Throughput Screening for Biomarker Discovery [PDF]
Disease Markers, 2015 Biomarkers are indicators of disease occurrence and progression. They can be used to assess normal biological and pathogenic processes or pharmacologic responses to a therapeutic intervention and, in some cases, may serve as potential drug and prognostic targets.
Tavan Janvilisri +4 more
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The Future of High-Throughput Screening
SLAS Discovery, 2008 High-throughput screening (HTS) is a well-established process in lead discovery for pharma and biotech companies and is now also being set up for basic and applied research in academia and some research hospitals. Since its first advent in the early to mid-1990s, the field of HTS has seen not only a continuous change in technology and processes but ...
Lorenz M. Mayr, Peter Fuerst
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High-Throughput Screening of NOX Inhibitors [PDF]
, 2019 Development of new, selective inhibitors of nicotinamide adenine dinucleotide phosphate oxidase (NOX) isoforms is important both for basic studies on the role of these enzymes in cellular redox signaling, cell physiology, and proliferation and for development of new drugs for diseases carrying a component of increased NOX activity, such as several ...
Zielonka, Jacek +4 more
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A High-Throughput Screen for Tuberculosis Progression
PLoS ONE, 2011 One-third of the world population is infected with Mycobacterium tuberculosis and multi-drug resistant strains are rapidly evolving. The noticeable absence of a whole organism high-throughput screening system for studying the progression of tuberculosis is fast becoming the bottleneck in tuberculosis research.
Carvalho, R. +8 more
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Screening and High-Throughput Platelet Assays [PDF]
, 2018 High-throughput assays are important biological research tools but are rarely utilized for platelet research. However, screening compounds for efficacy against a physiologically relevant cellular response in primary cells such as platelets can be an advantageous approach to compound screening and drug development. In this section we describe a panel of
Bye, Alexander P +2 more
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Microfluidic Tools for High-Throughput Screening [PDF]
BioTechniques, 2004 High-throughput screening (HTS) is an established technology in the pharmaceutical industry (1). Over the past decade, there has been a logarithmic increase in the industry’s ability to screen large combinatorial libraries of compounds against target molecules (2).
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High Throughput Screening with Multiphoton Excitation [PDF]
SLAS Discovery, 1999 Fluorescence detection is extensively used in high throughput screening. In HTS there is a continuous migration toward higher density plates and smaller sample volumes. In the present report we describe the advantages of two-photon or multiphoton excitation for HTS.
Ignacy Gryczynski +2 more
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High-Throughput Screening for Boride Superconductors
Inorganic ChemistryA high-throughput screening using density functional calculations is performed to search for stable boride superconductors from the existing materials database. The workflow employs the fast frozen phonon method as the descriptor to evaluate the superconducting properties quickly. 23 stable candidates are identified from the screening.
Shiya Chen +6 more
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Virtual High-Throughput Ligand Screening [PDF]
, 2014 In Structural Genomics projects, virtual high-throughput ligand screening can be utilized to provide important functional details for newly determined protein structures. Using a variety of publicly available software tools, it is possible to computationally model, predict, and evaluate how different ligands interact with a given protein. At the Center
Wayne F. Anderson +4 more
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