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Immobilization for High-Throughput Screening
2001Immobilization is an important and emerging approach in biotechnology for investigation into microbial and cellular processes. Immobilization methods have been used in the production of antibiotics (Ogaki, 1986; Mahmoud et al., 1987) and in other applied fields including, transplantation (Cotton, 1996; Hagihara et al, 1997), clinical (Chang, 1995; Wang
Christopher J. Silva +2 more
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Technological advances in high-throughput screening
Current Opinion in Chemical Biology, 1998A variety of assay technologies continue to be developed for high-throughput screening. These include cell-based assays, surrogate systems using microbial cells such as yeast and bacterial two-hybrid and three-hybrid systems, and systems to measure nucleic acid-protein and receptor-ligand interactions.
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Mycobacterium tuberculosis High-Throughput Screening
2016High-throughput screening is a valuable way to identify hit compounds that combined with a robust medicinal chemistry program could lead to the identification of new antibiotics. Here, we discuss our method for screening large compound libraries with virulent Mycobacterium tuberculosis, possibly one of the more difficult bacteria to use because of its ...
Nichole A. Tower +2 more
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High-Throughput Screening for Drug Combinations
2019The identification of drug combinations as alternatives to single-agent therapeutics has traditionally been a slow, largely manual process. In the last 10 years, high-throughput screening platforms have been developed that enable routine screening of thousands of drug pairs in an in vitro setting.
Marc Ferrer +10 more
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, 2002