Results 11 to 20 of about 1,236,846 (314)
RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes [PDF]
Nature Communications, 2017 Synthetic biology and metabolic engineering seek to re-engineer microbes into “living foundries” for the production of high value chemicals. Through a “design-build-test” cycle paradigm, massive libraries of genetically engineered microbes can be ...
Joseph Abatemarco +8 more
semanticscholar +3 more sources
Nature Communications, 2021 Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post ...
Boning Niu +9 more
doaj +1 more source
3D cell cultures toward quantitative high-throughput drug screening.
TIPS - Trends in Pharmacological Sciences, 2022 3D cell cultures are being utilized for drug discovery and development. However, there are still challenges to implementing them generally in quantitative high-throughput screening (HTS) due to the complexity of the 3D architecture, the time- and labor ...
Yichun Wang, H. Jeon
semanticscholar +1 more source
Science Advances, 2021 A high-throughput screening approach enables the discovery of tumor immune microenvironment modulator and immunotherapy booster. Combination immunotherapy is promising to overcome the limited objective response rates of immune checkpoint blockade (ICB ...
Haiyan Wang +11 more
semanticscholar +1 more source
Advancing liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry toward ultra-high-throughput analysis [PDF]
, 2020 Label-free high-throughput screening using mass spectrometry has the potential to provide rapid large-scale sample analysis at a speed of more than one sample per second.
Brown, Jeffery +5 more
core +1 more source
Extracellular matrix stiffness mediates radiosensitivity in a 3D nasopharyngeal carcinoma model
Cancer Cell International, 2022 Purpose Radiotherapy is one of the essential treatment modalities for nasopharyngeal carcinoma (NPC), however, radioresistance still poses challenges.
Yanhua Fang +6 more
doaj +1 more source
High-Throughput Transcriptomics Platform for Screening Environmental Chemicals.
Toxicological Sciences, 2021 New approach methodologies (NAMs) that efficiently provide information about chemical hazard without using whole animals are needed to accelerate the pace of chemical safety assessments.
J. Harrill +8 more
semanticscholar +1 more source
Cell Discovery, 2023 How cells adapt their gene expression to nutritional changes remains poorly understood. Histone H3T11 is phosphorylated by pyruvate kinase to repress gene transcription.
Xinyu Zhang +7 more
doaj +1 more source
Journal of biomolecular screening, 1999 The ability to identify active compounds ("hits") from large chemical libraries accurately and rapidly has been the ultimate goal in developing high-throughput screening (HTS) assays.
Ji-Hu Zhang, T. Chung, K. Oldenburg
semanticscholar +1 more source