Advancing liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry toward ultra-high-throughput analysis [PDF]
, 2020 Label-free high-throughput screening using mass spectrometry has the potential to provide rapid large-scale sample analysis at a speed of more than one sample per second.
Brown, Jeffery +5 more
core +1 more source
High throughput biodegradation-screening test to prioritize and evaluate chemical biodegradability [PDF]
, 2017 Comprehensive assessment of environmental biodegradability of pollutants is limited by the use of low throughput systems. These are epitomized by the Organisation for Economic Cooperation and Development (OECD) Ready Biodegradability Tests (RBTs), where ...
Martin, Timothy J. +5 more
core +2 more sources
RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes. [PDF]
, 2017 Synthetic biology and metabolic engineering seek to re-engineer microbes into living foundries for the production of high value chemicals. Through a design-build-test cycle paradigm, massive libraries of genetically engineered microbes can be constructed
Abate, Adam +8 more
core +1 more source
Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening [PDF]
, 2017 Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived from human induced pluripotent stem cells (iPSCs) is a powerful tool to identify tau-targeted ...
Chen, Robert +12 more
core +3 more sources
High-Throughput Screening of Acyl-CoA Thioesterase I Mutants Using a Fluid Array Platform [PDF]
, 2019 Screening target microorganisms from a mutated recombinant library plays a crucial role in advancing synthetic biology and metabolic engineering. However, conventional screening tools have several limitations regarding throughput, cost, and labor.
Kim, Taesung +5 more
core +1 more source
Computational screening of magnetocaloric alloys [PDF]
, 2020 An exciting development over the past few decades has been the use of high-throughput computational screening as a means of identifying promising candidate materials for a variety of structural or functional properties.
Bocarsly, Joshua D +2 more
core +2 more sources
Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]
, 2011 Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core +1 more source
High‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing [PDF]
, 2018 This is the peer reviewed version of the following article:Ioanna D. Styliari, et al, ‘High‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing’, Macromolecular Materials and Engineering, (2018), which has been published in ...
Alexander, Cameron +16 more
core +3 more sources
A fruitful fly forward : the role of the fly in drug discovery for neurodegeneration [PDF]
, 2014 AD, Alzheimer’s disease; APP, amyloid precursor protein; BBB, blood brain barrier; GFP, green fluorescent protein; HTS, high-throughput screening; HD, Huntington’s disease; LB, Lewy bodies; PD, Parkinson’s disease; PolyQ, Polyglutamine; RNAi, RNA ...
Briffa, Michelle +2 more
core +1 more source
High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
, 2018 BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E. +12 more
core +1 more source