Results 21 to 30 of about 16,128,167 (280)

Alginate-based 3D cancer cell culture for therapeutic response modeling

STAR Protocols, 2021
Summary: Two-dimensional (2D) culture of tumor cells fails to recapitulate some important aspects of cellular organization seen in in vivo experiments. In addition, cell cultures traditionally use non-physiological concentration of nutrients.
Farideh Davoudi, Samar Ghorbanpoor, Satoshi Yoda, Xiao Pan, Giovanna Stein Crowther, Xunqin Yin, Ellen Murchie, Aaron N. Hata, Henning Willers, Cyril H. Benes   +9 more
doaj   +1 more source

Microfluidic Technologies for High-Throughput Screening Applications [PDF]

, 2003
In this thesis, I present a strategy for the design and development of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed in prokaryotic hosts, where a few point mutations at the DNA level ...
Thorsen, Todd Addison
core   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +2 more sources

High-throughput bactericidal assays for monoclonal antibody screening against antimicrobial resistant Neisseria gonorrhoeae

Frontiers in Microbiology, 2023
Neisseria gonorrhoeae (gonococcus) is an obligate human pathogen and the etiological agent of the sexually transmitted disease gonorrhea. The rapid rise in gonococcal resistance to all currently available antimicrobials has become a significant public ...
Samuele Stazzoni, Marco Troisi, Valentina Abbiento, Valentina Abbiento, Claudia Sala, Emanuele Andreano, Rino Rappuoli, Rino Rappuoli   +7 more
doaj   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Barroso, Vanessa, Drewry, David H., Kessler, Albane, Pilar Manzano, M., Cotillo, Ignacio, Roquero, Irene, Alonso-Padilla, Julio, Bardera, Ana I., Navarro, Miguel, Manzano, Pilar, Brown, James R., Sherstnev, Alexander, Alvarez, Emilio, Rodríguez López, Ana, Fiandor, Jose M., Julio Martin, J., Dios-Antón, Francisco de, Kumar, Vinod, Peña, Imanol, Martin, José Julio, Gray, David W., Gray, David W.; id_orcid, Rodriguez, Ana, Navarro, M., Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo   +26 more
core   +1 more source

Advances in the application of high-throughput microfluidic platforms in precise diagnosis and treatment of tumors [PDF]

精准医学杂志
Although the treatment of malignant tumors has entered an era of comprehensive therapy integrating chemotherapy, targeted therapy, immunotherapy, and other modalities, there is still a significant gap from individualized precise treatment.
DOU Liliang, CHU Jiahui, LIU Lian
doaj   +1 more source

Protocol for tissue slice cultures from human solid tumors to study therapeutic response

STAR Protocols, 2021
Summary: The impact of systemic therapy on the tumor microenvironment has been difficult to study in human solid tumors. Our protocol describes steps for establishing slice cultures to investigate response to chemotherapies, immunotherapies, or adoptive ...
Heidi L. Kenerson, Kevin M. Sullivan, Kevin P. Labadie, Venu G. Pillarisetty, Raymond S. Yeung   +4 more
doaj   +1 more source

Methods to identify the unexplored diversity of microbial exopolysaccharides

Frontiers in Microbiology, 2015
Microbial exopolysaccharides (EPS) are a structurally very diverse class of molecules. A number of them have found their application in rather diverging fields that extend from medicine, food and cosmetics on the one side to construction, drilling and ...
Broder eRühmann, Jochen eSchmid, Volker eSieber   +2 more
doaj   +1 more source

A high-throughput and highly automated genotoxicity screening assay

ALTEX, 2021
The increasing number of compounds under development and chemicals in commerce that require safety assessments pose a serious challenge for regulatory agencies worldwide. In vitro screening using toxicogenomic biomarkers has been proposed as a first-tier screen in chemical assessment and has been endorsed internationally.
Renxiang, Chen, Yun-Tien, Lin, Albert J, Fornace, Heng-Hong, Li   +3 more
openaire   +2 more sources

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source