Results 41 to 50 of about 16,128,167 (280)

Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening

Sensors, 2016
Microfluidics-based drug-screening systems have enabled efficient and high-throughput drug screening, but their routine uses in ordinary labs are limited due to the complexity involved in device fabrication and system setup.
Zhuofa Chen, Weizhi Li, Gihoon Choi, Xiaonan Yang, Jun Miao, Liwang Cui, Weihua Guan   +6 more
doaj   +1 more source

A Rapid Transglutaminase Assay for High-Throughput Screening Applications [PDF]

SLAS Discovery, 2006
Transglutaminases (TGs) are widely distributed enzymes that catalyze posttranslational modification of proteins by Ca(2+)-dependent cross-linking reactions. The family members of TGs participate in many significant processes of biological functions such as tissue regeneration, cell differentiation, apoptosis, and certain pathologies.
Yu-Wei, Wu, Yu-Hui, Tsai
openaire   +2 more sources

High-Throughput Screening to Predict Chemical-Assay Interference [PDF]

Scientific Reports, 2020
AbstractThe U.S. federal consortium on toxicology in the 21st century (Tox21) produces quantitative, high-throughput screening (HTS) data on thousands of chemicals across a wide range of assays covering critical biological targets and cellular pathways.
Alexandre Borrel, Ruili Huang, Srilatha Sakamuru, Menghang Xia, Anton Simeonov, Kamel Mansouri, Keith A. Houck, Richard S. Judson, Nicole C. Kleinstreuer   +8 more
openaire   +2 more sources

Development of a High Throughput Platform for Screening Glycoside Hydrolases based on Oxime-NIMS

Frontiers in Bioengineering and Biotechnology, 2015
Cost effective hydrolysis of biomass into sugars for biofuel production requires high-performance low-cost glycoside hydrolase (GH) cocktails that are active under demanding process conditions.
Kai eDeng, Kai eDeng, Joel M Guenther, Joel M Guenther, Jian eGao, Benjamin Paul Bowen, Huu eTran, Huu eTran, Vimalier eReyes-Ortiz, Vimalier eReyes-Ortiz, Xiaoliang eCheng, Xiaoliang eCheng, Noppadon eSathitsuksanoh, Noppadon eSathitsuksanoh, Richard eHeins, Richard eHeins, Taichi E Takasuka, Lai eBergeman, Henrik eGeertz-Hansen, Henrik eGeertz-Hansen, Sam eDeutsch, Sam eDeutsch, Dominique eLoqué, Dominique eLoqué, Kenneth eSale, Kenneth eSale, Blake eSimmons, Blake eSimmons, Paul D Adam, Paul D Adam, Paul D Adam, Anup K Singh, Anup K Singh, Brian Grant Fox, Brian Grant Fox, Trent Russell Northen, Trent Russell Northen   +36 more
doaj   +1 more source

Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins [PDF]

, 2012
Fluorescent fusion proteins are widely used to study protein localization and interaction dynamics in living cells. However, to fully characterize proteins and to understand their function it is crucial to determine biochemical characteristics such as ...
Sandra B. Hake (165089), Antonia Jack (165084), Sandra B Hake, Patricia Wolf, Pichler Garwin, Pichler, Garwin, Hake, Sandra B., Antonia Jack, Wolf Patricia, Garwin Pichler (165082), Jack Antonia, Wolf, Patricia, Jack, Antonia, Hake Sandra B., Garwin Pichler, Patricia Wolf (165088)   +15 more
core   +2 more sources

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Protocol to identify small-molecule inhibitors against cancer drug resistance

STAR Protocols
Summary: Drug resistance has emerged as a critical challenge in clinical cancer treatment. Here, we present a high-throughput screening protocol to identify therapeutic small-molecule inhibitors against drug-resistant cancer cells.
Juan Wei, She-Yu Zhang, Xue-Yuan Zhou, Yong Wei, Hao-Ran Jia, Qin Wu, Weihong Tan   +6 more
doaj   +1 more source

Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni

Frontiers in Cellular and Infection Microbiology, 2022
Schistosomiasis is a parasitic neglected disease with praziquantel (PZQ) utilized as the main drug for treatment, despite its low effectiveness against early stages of the worm. To aid in the search for new drugs to tackle schistosomiasis, computer-aided
Bernardo Pereira Moreira, Izabella Cristina Andrade Batista, Naiara Clemente Tavares, Tom Armstrong, Sandra Grossi Gava, Gabriella Parreiras Torres, Marina Moraes Mourão, Franco H. Falcone   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Protocol for screening inhibitors of the fungal sphingolipid-metabolizing enzyme ceramide synthase

STAR Protocols
Summary: Fungal sphingolipids have emerged as potent antifungal targets based on cumulative evidence demonstrating that fungal sphingolipid metabolism is essential to the virulence of pathogenic fungi. Here, we present a protocol to screen for inhibitors
Andy Zhong, Deveney Dasilva, Nivea Pereira de Sa, Jeehyun Karen You, Maurizio Del Poeta   +4 more
doaj   +1 more source