Results 51 to 60 of about 137,634 (294)
High-throughput drug screening of fine-needle aspiration-derived cancer organoids
STAR Protocols, 2020 Summary: Generation of fine-needle aspiration (FNA)-derived cancer organoids has allowed us to develop a number of downstream applications. In this protocol, we start with organoids cultured in a semi-solid format.
Kensey Bergdorf +7 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Schistosomiasis is a parasitic neglected disease with praziquantel (PZQ) utilized as the main drug for treatment, despite its low effectiveness against early stages of the worm. To aid in the search for new drugs to tackle schistosomiasis, computer-aided
Bernardo Pereira Moreira +7 more
doaj +1 more source
Development of High-Throughput Screening Assay for Antihantaviral Therapeutics [PDF]
SLAS Discovery, 2017 Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. There is no treatment for hantavirus diseases at present. Therapeutic intervention during early stages of viral infection can improve the outcome of this zoonotic viral illness.
Roy, Anuradha, Mir, Mohammad A.
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
STAR ProtocolsSummary: The interaction between cell surface receptors and their ligands is crucial for intercellular communication. However, current techniques for identifying direct receptor-ligand interactions remain limited.
Xiaoli Hu, Yiguo Wang
doaj +1 more source
A system for performing high throughput assays of synaptic function. [PDF]
PLoS ONE, 2011 Unbiased, high-throughput screening has proven invaluable for dissecting complex biological processes. Application of this general approach to synaptic function would have a major impact on neuroscience research and drug discovery.
Chris M Hempel +9 more
doaj +1 more source
STAR Protocols, 2021 Summary: Histone deacetylases (HDACs) are ubiquitous enzymes that cleave post-translational ε-N-acyllysine modifications. The continued identification of diverse acyl modifications at lysine residues in proteins has resulted in discovery of new insight ...
Carlos Moreno-Yruela, Christian A. Olsen
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The identification of bioactive natural products by High Throughput Screening (HTS)
, 2020 This chapter outlines the processes involved in the screening of natural product (NP) extracts for biological activity. The topics covered include biological diversity, the collection of biota samples, the preparation of NP extracts for screening, high ...
Jenkins, ID +4 more
core +1 more source
Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament [PDF]
, 2018 The protein ASC is a central component of most inflammasome complexes, forming functional oligomeric filaments that activate large amounts of pro-caspase-1 for further IL-1β processing and the induction of Gasdermin D-dependent cell death.
Jonathan Vesin +15 more
core +1 more source