Results 41 to 50 of about 112,064 (133)
Recent developments in the rapid analysis of plants and tracking their bioactive constituents [PDF]
, 2009 Natural products chemistry has witnessed many new developments in the last 5 years like extractions with subcritical water and ionic liquids, LC/HRMS and LC/SPE/cryo-NMR, UHPLC, TLC/MS, MS-based preparative HPLC, comprehensive chromatography (GC × GC, LC
Beek, T.A., van +7 more
core +2 more sources
STAR Protocols, 2022 Summary: Well-characterized small molecules enable the study of cell processes and facilitate target validation. Here, we describe a high-content multiplex screen to investigate cell viability over 48 h, which can be combined with investigating ...
Amelie Tjaden +4 more
doaj +1 more source
Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening
Sensors, 2016 Microfluidics-based drug-screening systems have enabled efficient and high-throughput drug screening, but their routine uses in ordinary labs are limited due to the complexity involved in device fabrication and system setup.
Zhuofa Chen +6 more
doaj +1 more source
Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]
, 2011 Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet +10 more
core +1 more source
Stress-Based High-Throughput Screening Assays to Identify Inhibitors of Cell Envelope Biogenesis
Antibiotics, 2020 The structural integrity of the Gram-negative cell envelope is guarded by several stress responses, such as the σE, Cpx and Rcs systems. Here, we report on assays that monitor these responses in E.
Maurice Steenhuis +3 more
doaj +1 more source
A system for performing high throughput assays of synaptic function. [PDF]
PLoS ONE, 2011 Unbiased, high-throughput screening has proven invaluable for dissecting complex biological processes. Application of this general approach to synaptic function would have a major impact on neuroscience research and drug discovery.
Chris M Hempel +9 more
doaj +1 more source
A high-throughput and highly automated genotoxicity screening assay
ALTEX, 2021 The increasing number of compounds under development and chemicals in commerce that require safety assessments pose a serious challenge for regulatory agencies worldwide. In vitro screening using toxicogenomic biomarkers has been proposed as a first-tier screen in chemical assessment and has been endorsed internationally.
Renxiang, Chen +3 more
openaire +2 more sources
Identification of Small Molecules that Enhance Synaptogenesis Using Synapse Microarrays [PDF]
, 2013 Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads.
Ghosh, Balaram +7 more
core +1 more source
Development of a High Throughput Platform for Screening Glycoside Hydrolases based on Oxime-NIMS
Frontiers in Bioengineering and Biotechnology, 2015 Cost effective hydrolysis of biomass into sugars for biofuel production requires high-performance low-cost glycoside hydrolase (GH) cocktails that are active under demanding process conditions.
Kai eDeng +36 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Schistosomiasis is a parasitic neglected disease with praziquantel (PZQ) utilized as the main drug for treatment, despite its low effectiveness against early stages of the worm. To aid in the search for new drugs to tackle schistosomiasis, computer-aided
Bernardo Pereira Moreira +7 more
doaj +1 more source