Results 101 to 110 of about 280,529 (308)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data

BMC Bioinformatics, 2017
Background Lipids are ubiquitous and serve numerous biological functions; thus lipids have been shown to have great potential as candidates for elucidating biomarkers and pathway perturbations associated with disease.
Jeremy P. Koelmel, Nicholas M. Kroeger, Candice Z. Ulmer, John A. Bowden, Rainey E. Patterson, Jason A. Cochran, Christopher W. W. Beecher, Timothy J. Garrett, Richard A. Yost   +8 more
doaj   +1 more source

Studies of Chamber Organic Aerosol using an Aerodyne High-Resolution Time-of-Flight Aerosol Mass Spectrometer [PDF]

, 2011
Secondary organic aerosol (SOA) contributes a substantial fraction to total ambient particulate mass. SOA is a complex mixture of different organic species formed via many gas- and particle-phase reaction pathways. The Aerodyne aerosol mass spectrometer (
Chhabra, Puneet Singh
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Comparative Lipidomics of Oral Commensal and Opportunistic Bacteria

Metabolites
The oral cavity contains a vast array of microbes that contribute to the balance between oral health and disease. In addition, oral bacteria can gain access to the circulation and contribute to other diseases and chronic conditions.
Paul L. Wood, Annie Le, Dominic L. Palazzolo   +2 more
doaj   +1 more source

Advanced methods in fourier transform ion cyclotron resonance mass spectrometry [PDF]

Mass spectrometry (MS) is a powerful analytical technique used to characterize various compounds by measuring the mass-to-charge ratio (m/z). Among different types of mass analyzers, Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR ...
Qi, Yulin
core  

High-Resolution Integrated Microfluidic Probe for Mass Spectrometry Imaging of Biological Tissues

, 2023
Nanospray desorption electrospray ionization (nano-DESI) is an ambient ionization technique that enables molecular imaging of biological samples with high spatial resolution.
Hang, Hu, Julia, Laskin, Xiangtang, Li
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The role of direct high-resolution mass spectrometry in foodomics

Analytical and Bioanalytical Chemistry, 2015
Foodomics has been defined as a global discipline in which advanced analytical techniques and bioinformatics are combined to address different questions in food science and nutrition. There is a growing number of works on the development and application of non-targeted omics methods in foodomics, which reflects that this emerging discipline is already ...
Ibáñez, Clara, Simó, Carolina, García-Cañas, Virginia, Acunha, T., Cifuentes, Alejandro   +4 more
openaire   +3 more sources

Clinical perspectives of high-resolution mass spectrometry-based proteomics in neuroscience: exemplified in amyotrophic lateral sclerosis biomarker discovery research.

, 2008
Biomarker discovery is a central application in today\u27s proteomic research. There is an urgent need for valid biomarkers to improve diagnostic tools and treatment in many disorders, such as the rapidly progressing neurodegenerative disorder ...
Hanrieder, Jörg,, Ekegren, Titti, Ekegren, Titti,, Bergquist, Jonas, Hanrieder, J\uf6rg, Bergquist, Jonas,   +5 more
core   +1 more source