Results 31 to 40 of about 5,403 (145)

Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease. [PDF]

PLoS ONE, 2015
This study combined high resolution mass spectrometry (HRMS), advanced chemometrics and pathway enrichment analysis to analyse the blood metabolome of patients attending the memory clinic: cases of mild cognitive impairment (MCI; n = 16), cases of MCI ...
Stewart F Graham, Olivier P Chevallier, Christopher T Elliott, Christian Hölscher, Janet Johnston, Bernadette McGuinness, Patrick G Kehoe, Anthony Peter Passmore, Brian D Green   +8 more
doaj   +1 more source

Rapid Determination of Five Alkaloids in Catering Crayfish by QuEChERS-UPLC-MS/MS

Shipin gongye ke-ji, 2023
In this study, a method for the determination of morphine, codeine, nacodine, papaverine and tibain residues in catering crayfish by ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was established.
Ling YU, Lihua SONG
doaj   +1 more source

Urine Metabolome during Parturition

Metabolites, 2020
In recent years, some studies have described metabolic changes during human childbirth labor. Metabolomics today is recognized as a powerful approach in a prenatal research context, since it can provide detailed information during pregnancy and it may ...
Federica Gevi, Alessandra Meloni, Rossella Mereu, Veronica Lelli, Antonella Chiodo, Antonio Ragusa, Anna Maria Timperio   +6 more
doaj   +1 more source

Changes in Serum N-Glycome for Risk Drinkers: A Comparison with Standard Markers for Alcohol Abuse in Men and Women

Biomolecules, 2022
Background and aim: Glycomic alterations serve as biomarker tools for different diseases. The present study aims to evaluate the diagnostic capability of serum N-glycosylation to identify alcohol risk drinking in comparison with standard markers. Methods:
Róisín O’Flaherty, Ádám Simon, Manuela Alonso-Sampedro, Sonia Sánchez-Batán, Carmen Fernández-Merino, Francisco Gude, Radka Saldova, Arturo González-Quintela   +7 more
doaj   +1 more source

Qualitative and Quantitative Analysis of the Major Constituents in WLJ Herbal Tea Using Multiple Chromatographic Techniques

Molecules, 2018
Quality control of Chinese herbal tea remains a challenge due to our poor knowledge of their complex chemical profile. This study aims to investigate the chemical composition of one of the best-selling and famous brand of beverage in China, Wanglaoji ...
Chao-Zhan Lin, Run-Jing Zhang, Yu-Feng Yao, Xiao-Dan Huang, Rong-Bo Zheng, Bo-Jian Wu, Chen-Chen Zhu   +6 more
doaj   +1 more source

A Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry Quantitative Method for Determination of Baricitinib in Plasma, and Its Application in a Pharmacokinetic Study in Rats

Molecules, 2020
Baricitinib, is a selective and reversible Janus kinase inhibitor, is commonly used to treat adult patients with moderately to severely active rheumatoid arthritis (RA).
Essam Ezzeldin, Muzaffar Iqbal, Yousif A. Asiri, Azza A Ali, Prawez Alam, Toqa El-Nahhas   +5 more
doaj   +1 more source

Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle

Engineering, 2023
Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses.
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc   +13 more
doaj   +1 more source

Development and Validation of UPLC–MS/MS Method for Quantitative Analysis of 5-Fluorouracil in Aqueous Humor of Rabbits

Separations, 2023
5-Fluorouracil (5-FU) is now used in eye drops for the management of conjunctival malignant melanoma, intraepithelial neoplasia, and corneal and conjunctival squamous cell carcinoma.
Mohd Abul Kalam, Sulaiman S. Alhudaithi, Adel Ali Alhowyan, Muzaffar Iqbal, Mohammad Raish, Abdullah K. Alshememry, Musaed Alkholief, Aliyah A. Almomen, Aws Alshamsan   +8 more
doaj   +1 more source

High-Throughput Profiling of Serological Immunoglobulin G N-Glycome as a Noninvasive Biomarker of Gastrointestinal Cancers

Engineering, 2023
Immunoglobulin G (IgG) N-glycosylation plays a crucial role in the development of inflammatory diseases. This study aimed to evaluate the diagnostic performance of IgG for gastrointestinal (GI) cancer subtypes.
Pengcheng Liu, Xiaobing Wang, Aishe Dun, Yutong Li, Houqiang Li, Lu Wang, Yichun Zhang, Cancan Li, Jinxia Zhang, Xiaoyu Zhang, Lixing Ma, Haifeng Hou   +11 more
doaj   +1 more source

HILIC UPLC/ QTof MS Method Development for the Quantification of AGEs Inhibitors - Trouble Shooting Protocol

Combinatorial Chemistry & High Throughput Screening
Objective: The paper reports an attempt to develop and validate a HILIC UPLC/ QTof MS method for quantifying N-ε-carboxymethyl-L-lysine (CML) in vitro, testing N-ε- carboxy[D2]methyl-L-lysine (d2-CML), and N-ε-carboxy[4,4,5,5-D4]methyl-L-lysine (d4-CML) as internal standards.
Velichkova, Stefaniya, Foubert, Kenn, Theunis, Mart, Pieters, Luc   +3 more
openaire   +3 more sources