Results 61 to 70 of about 9,325 (168)

Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Graphical Highlights Spatiotemporal immune heterogeneity shapes distinct and evolving immune ecosystems in ovarian cancer. Multimodal biomarkers enable biologically informed patient stratification beyond static single‐marker approaches. Precision immunotherapy should match dominant immune barriers across lesions and treatment stages.
Xinfeng Yang, Yida Wang, Haiyue You, Jingyi Gao, Yangkun Feng, Feng Zhang, Yan Zhang, Bing Zhang, Shaojie Zhao, Yanfang Gu   +9 more
wiley   +1 more source

Overall survival post secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent colorectal cancer with peritoneal metastases

World Journal of Surgical Oncology
Background Colorectal cancer is the third-most common malignancy worldwide. It has the potential to develop peritoneal metastases (CRPM), which can be treated using cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Raymond Hayler, Celine Garrett, Jessica Guo, Shoma Barat, Mina Sarofim, Ruwanthi Wijayawardana, Nima Ahmadi, Winston Liauw, David L. Morris   +8 more
doaj   +1 more source

Anesthetic management of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A case series

Asian Journal of Medical Sciences
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment for advanced abdominopelvic malignancies with peritoneal carcinomatosis. Cytoreductive surgery (CRS) with HIPEC offers hope by increasing the survival rates of these cancers ...
Aswini Lakshminarasimhan , Rajasekar Radhakrishnan , Gowtham Selvarasu   +2 more
doaj   +1 more source

Detection and treatment of peritoneal metastases in colon cancer: COLOPEC trial compared to routine practice

Colorectal Disease, Volume 28, Issue 9, September 2026.
Abstract Aim The randomized COLOPEC trial demonstrated no benefit of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in preventing peritoneal metastases in locally advanced colon cancer. Because all patients underwent a diagnostic laparoscopy at 18 months, the study lacked a true control arm, leaving the effect of early detection and ...
Iris Hochstenbach, Julie J. M. Hamm, Eva Rademaker, Arend G. J. Aalbers, Djamila Boerma, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Ignace H. J. T. De Hingh, Niels F. M. Kok, Jurriaan B. Tuynman, Eva V. E. Madsen, Johannes H. W. de Wilt, Esther C. J. Consten, Henderik L. van Westreenen, Pieter J. Tanis, on behalf of the COLOPEC Collaborators Group, Dutch Snapshot Research Group and Dutch Complex Colon Cancer Initiative, Caroline S. Andeweg, Vivian P. Bastiaenen, Willem A. Bemelman, Jarmila D.W. van der Bilt, Johanne Bloemen, Frank C. den Boer, Daan ten Bokkel Huinink, Cancer Clinic, Alexandra R.M. Brandt‐Kerkhof, Andre J.A. Bremers, Walter J.A. Brokelman, Huib A. Cense, Geert‐Jan Creemers, Johannes Crezee, Rogier M.P.H. Crolla, Jan‐Willem T. Dekker, Jennifer Demelinne, Marc J. van Det, Ziekehuisgroep Twente, Karin K. van Diepen, Marjolein Diepeveen, Gastrointestinal Surgery, Marcel G.W. Dijkgraaf, Eino B. van Duyn, Medisch Spectrum Twente, Esther D. van den Ende, Ziekehuisgroep Twente, Pauline Evers, Hans F.J. Fabry, Floris T.J. Ferenschild, Maashospital Pantein, Sebastiaan Festen, Onze Lieve Vrouwen Gasthuis, Anna A.W. van Geloven, Erwin van der Harst, Jeroen Heemskerk, Joost T. Heikens, Daniel A. Hess, Bas Inberg, Streekziekenhuis Koningin Beatrix, Jan Jansen, Charlotte E.L. Klaver, Frank W.H. Kloppenberg, Treant Zorggroep, Thomas J.M. Kootstra, R. T. J. Kortekaas, Maartje Los, H. C. J. van der Mijle, Linda Mol, Gijsbert D. Musters, Peter A. Neijenhuis, Simon W. Nienhuijs, Loes van den Nieuwenhof, Koen C.M.J. Peeters, Sebastiaan W. Polle, Jolien Pon, Pieter Poortman, Cornelis J.A. Punt, Sandra A. Radema, Bert van Ramshorst, Philip R. de Reuver, Koen P. Rovers, Roderick F. Schmitz, Lotte Schoonderwoerd, Nina Sluiter, Dirkje W. Sommeijer, Eric Sonneveld, T. C. van Sprundel, Sanne C. Veltkamp, Maarten Vermaas, Victor J. Verwaal, Emma Wassenaar, Johannes A. Wegdam, Marinke Westerterp, Marinus J. Wiezer, Daniel D. Wisselink, Fennie Wit, Arjen J. Witkamp, Karlijn van Woensdregt, Edwin S. van der Zaag, David D.E. Zimmerman, Mandy Zournas, Annette van Zweeden, D. C. Van der Aa, S. M. Van Aalten, I. Aanen, F. J. Amelung, Den Bosch, P. Van Amstel, E. Ancion, J. J. Atema, T. S. Aukema, V. Baart, E. Z. Barsom, V. P. Bastiaenen, T. Bazuin, M. A. J. Becker, V. M. Belvroy, R. H. A. Berndsen, B. Biersteker, J. D. W. Van der Bilt, J. G. Bloemen, S. Bluiminck, F. C. Den Boer, E. G. Boerma, M. C. Boonstra, W. A. A. Borstlap, L. A. Brugts, J. W. A. Burger, T. A. Burghgraef, S. M. M. De Castro, M. Cleveringa, R. J. S. Coelen, A. Demirkiran, E. Dijkema, S. Dijkink, S. A. Dingemans, L. Van Dullemen, E. B. Van Duyn, A. J. Eleveld, H. A. Galema, E. G. M. Van Geffen, R. T. J. Geitenbeek, A. A. W. Van Geloven, A. H. C. Gielen, C. A. Gispen, M. J. P. M. Govaert, V. P. Groot, B. A. Grotenhuis, A. A. J. Grüter, S. F. Hardon, A. G. Den Hartog, K. Havenga, J. A. G. Van der Heijden, F. Heilijgers, T. B. M. Van den Heuvel, R. S. Hijmans, J. Van Hilst, J. C. Hol, S. Janki, A. C. H. M. Jongen, I. Kappers, S. Karhof, B. A. J. Kertzman, M. M. Kieboom, N. Koemans, J. L. M. Konsten, W. H. Kopp, O. W. Kranenburg, P. Krielen, A. Kumas, M. Kusters, D. P. V. Lambrichts, B. Lamme, G. L. Van Leeuwen, E. W. Lockhorst, H. Lutfi, S. Malm, H. T. J. Mantel, G. A. Martini, P. Meijer, J. Melenhorst, D. M. Mens, MC Erasmus, M. J. H. Metman, L. C. F. De Nes, L. R. Moolenaar, J. A. Nieuwstraten, J. Nonner, S. E. Van Oostendorp, S. J. Oosterling, C. M. W. Pesch, C. M. L. Peters, M. W. H. Philipsen, W. Y. Van der Plas, M. M. Poelman, F. Polat, A. E. Posma‐Bouman, B. B. Pultrum, J. M. Van Rees, W. P. Reinders, P. R. De Reuver, M. C. Richir, T. W. H. Rijnhout, M. M. Romeijn, D. Roorda, C. C. Van Rossem, J. Rothbarth, M. Ruig, H. G. Sahin, I. Said, R. A. Schasfoort, J. Scholten, P. M. E. Schuivens, D. Schweitzer, C. Sietses, M. Sietzema, G. D. Slooter, N. Smakman, B. P. Smalbroek, E. J. Spillenaar Bilgen, E. J. A. Steller, T. F. Stoop, M. Straver, S. K. Stuart, A. Suntharan, A. K. Talsma, K. Trumpi, J. Veenhuizen, A. W. H. Van de Ven, E. G. G. Verdaasdonk, P. M. Verheijen, A. Villerius‐Meijer, M. Vissers, E. L. K. Voogt, R. P. H. De Vries, S. T. Van Vugt, D. D. De Waard, T. R. Wagner, A. K. Warps, R. H. A. Welling, M. Westerterp, J. K. Wiggers, A. R. Wijsmuller, C. D. M. Witjes, B. Zamaray, N. Van Zenden, S. J. M. Zomer, E. S. Zwanenburg, E. S. Zwart, S. L. M. Zwetsloot, M. J. Lahaye, P. D. Siersema, P. Snaebjornsson   +250 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

An Open Source Automated Tumor Infiltrating Lymphocytes Algorithm for Prognosis in Primary Small Bowel Adenocarcinoma Using Routine Hematoxylin and Eosin Stained Sections

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Objective While tumor‐infiltrating lymphocytes (TILs) are prognostic in various cancers, their role in small bowel adenocarcinoma (SBA) is unexplored. This study evaluates the prognostic significance of digitally quantified TILs in SBA. Methods Using digital pathology (QuPath) on hematoxylin and eosin (H&E)‐stained slides from 62 SBA cases, we
Minying Deng, Xin Liu, Yuanlong Luo, Ayizimugu Abuduwaili, Qi Song, Rongkui Luo, Wen Huang, Lei Xu, Xiaolei Zhang, Lin Sun, Jieakesu Su, Chen Xu, Yingyong Hou   +12 more
wiley   +1 more source

The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: HIPEC Technologies

This manuscript reports the results of an international consensus on technologies of hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) performed with the following goals: To provide recommendations for the technological parameters to ...
Kusamura, Shigeki, Villeneuve, Laurent, VAN DER SPEETEN, Kurt, Piso, Pompiliu, Glehen, Olivier, Gonzalez-Moreno, Santiago, Verwaal, Vic J.   +6 more
core   +1 more source

HIPEC treatment of peritoneal carcinomatosis in colorectal and gastric cancer [PDF]

, 2015
This thesis focuses on the treatment of peritoneal metastases of gastric and colorectal cancer, specifically using cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Braam, H.J.W.
core   +3 more sources

Prophylactic hyperthermic intraperitoneal chemotherapy is associated with improved disease-free survival in pathologic T4 colorectal cancer: a propensity score–matched cohort study

World Journal of Surgical Oncology
Background Pathologic T4 colorectal cancer (CRC) carries a high risk of peritoneal recurrence despite curative resection. Early postoperative hyperthermic intraperitoneal chemotherapy (HIPEC) may enhance intraperitoneal cytotoxic exposure and improve ...
Rongpeng Chen, Sihan Hu, Zhicheng Feng, Feng Xiao, Guoqiang Wang   +4 more
doaj   +1 more source

Risk factors of chronic kidney disease in cisplatin-based hyperthermia intraperitoneal chemotherapy

International Journal of Hyperthermia
Purpose Cisplatin is commonly prescribed in hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancy. Acute kidney injury (AKI) is regarded as a common complication after HIPEC combined with cytoreductive surgery (CRS).
Chih-Chung Cheng, Hung-Chieh Yeh, Pei-Wen Su, Chien-Lin Ho, Sheng-Chi Chang   +4 more
doaj   +1 more source