Results 71 to 80 of about 8,147 (216)

The Negative Impact of a Non‐Therapeutic Laparotomy in Patients With Inoperable Colorectal Peritoneal Metastases

Journal of Surgical Oncology, Volume 133, Issue 7, Page 843-851, June 2026.
ABSTRACT Background The peritoneum is the third most prevalent location for metastases of colorectal cancer. In patients with resectable disease, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC) is the preferred treatment in the Netherlands, achieving median overall survival (OS) of 36–42 months. However, during
Teun van den Heuvel, Lars van Kesteren, Simon Nienhuijs, Pim Burger, Tineke Buffart, Jurriaan Tuynman, Ignace De Hingh   +6 more
wiley   +1 more source

MODERN STRATEGY IN TREATMENT OF PERITONEAL CARCINOMATOSIS

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2017
Peritoneal carcinomatosis (PC) is a common manifestation of progression in peritoneal and gynecologic malignancies. Current primary strategy in treatment of PC is the concept of regional influence by the way of cytoreductive surgery and intraperitoneal ...
A. A. Zakharenko, D. A. Zaitcev, M. A. Belyaev, A. A. Trushin, O. A. Ten, A. S. Natkha, K. N. Vovin, V. A. Rybalchenko   +7 more
doaj   +1 more source

Inflammatory Markers may Determine Postoperative Complications in Cases of Peritoneal Carcinomatosis of Ovarian Origin Treated With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Journal of Surgical Oncology, Volume 133, Issue 7, Page 918-925, June 2026.
ABSTRACT Background and Objectives This study aimed to evaluate the ability of perioperative inflammatory markers to discriminate postoperative complications within 6 months in patients with ovarian cancer–related peritoneal metastasis undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Donmez Mustafa, Bisgin Tayfun, Manoglu Berke, Sokmen Selman, Sensoy Basoglu Ecem, Boztas Nilay, Ozgul Ozkardesler Sevda   +6 more
wiley   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Risk factors of chronic kidney disease in cisplatin-based hyperthermia intraperitoneal chemotherapy

International Journal of Hyperthermia
Purpose Cisplatin is commonly prescribed in hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancy. Acute kidney injury (AKI) is regarded as a common complication after HIPEC combined with cytoreductive surgery (CRS).
Chih-Chung Cheng, Hung-Chieh Yeh, Pei-Wen Su, Chien-Lin Ho, Sheng-Chi Chang   +4 more
doaj   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, Volume 13, Issue 28, 18 May 2026.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Anesthesia and chemotherapy meet: the nursing of the cancer patient undergoing HIPEC in the story of a clinical case [PDF]

reservedINTRODUZIONE: Dalla storia di vita di un paziente che ho avuto modo di assistere in questo ultimo anno, nasce in me la volontà di approfondire il legame tra anestesia e chemioterapia che è perfettamente incarnato in quella che è l’HIPEC e l ...
SCIVOLETTO, SARA
core  

Prophylactic hyperthermic intraperitoneal chemotherapy is associated with improved disease-free survival in pathologic T4 colorectal cancer: a propensity score–matched cohort study

World Journal of Surgical Oncology
Background Pathologic T4 colorectal cancer (CRC) carries a high risk of peritoneal recurrence despite curative resection. Early postoperative hyperthermic intraperitoneal chemotherapy (HIPEC) may enhance intraperitoneal cytotoxic exposure and improve ...
Rongpeng Chen, Sihan Hu, Zhicheng Feng, Feng Xiao, Guoqiang Wang   +4 more
doaj   +1 more source

Anesthetic management of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A case series

Asian Journal of Medical Sciences
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment for advanced abdominopelvic malignancies with peritoneal carcinomatosis. Cytoreductive surgery (CRS) with HIPEC offers hope by increasing the survival rates of these cancers ...
Aswini Lakshminarasimhan , Rajasekar Radhakrishnan , Gowtham Selvarasu   +2 more
doaj   +1 more source

Prognostic Nomogram for Ovarian Cancer Patients on First‐Line Maintenance Therapy With PARP Inhibitors: A Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective To develop and validate a prognostic nomogram that integrates clinical variables and biomarker statuses for predicting progression‐free survival (PFS) and overall survival (OS) in patients with advanced epithelial ovarian cancer (OC) receiving first‐line poly (ADP‐ribose) polymerase inhibitor (PARPi) maintenance therapy.
Shuran Tan, Siyu Yang, Xuerui Duan, Yu Zhang   +3 more
wiley   +1 more source