Results 71 to 80 of about 19,293 (297)

Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface [PDF]

, 2009
Plasma concentrations of biologically active vitamin D (1,25- (OH)2D) are tightly controlled via feedback regulation of renal 1-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes.
Albertson, Anderson, Arai, Avila, Barrera, Barrera, Bock, Bodnar, Boris Novakovic, Carter, Chaddha, Chiu, Chung, Coan, d'Alesio, Danielle Evain-Brion, Davis, Deeb, DeLuca, Delvin, Delvin, Diaz, Dimitriadis, Dodds, Du, Dusso, Eva Dimitriadis, Evans, Evans, Fischer, Friso, Holick, Hong Kiat Ng, Jeffrey M. Craig, Jennings, Kim, Kohler, Kovacs, Kumar, Lauridsen, Leader, Lechner, Li, Liu, Lohnes, Lopez, Lopez, Makin, Malloy, Mandy Sibson, Masuda, Muller, Murayama, Nelen, Nelen, Nelen, Novakovic, Ohyama, Pattillo, Pattillo, Paulson, Pavan, Peehl, Pendas-Franco, Pospechova, Rahnama, Rakyan, Richard Saffery, Ron, Ross, Ross, Ruth Morley, Salle, Seely, Serman, Shih Ie, Sikora, Siu-Caldera, Soundararajan, Stephan Beck, Stephanou, Sung, Tapia, Tashiro, Taylor, Thierry Fournier, Thomas Down, Tsang, Ursula Manuelpillai, Valdivielso, van der Molen, Vardhman Rakyan, Vigano, von Rango, Whitfield, Wietrzyk, Wong, Wong, Xie, Zehnder, Zhang, Zhou   +101 more
core   +3 more sources

Comparative Outcomes of Reinforced Tension‐Line Sutures Versus Standard Closure Techniques in Patients Undergoing Laparotomy: A Systematic Review and Meta‐Analysis

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The reinforced tension‐line suture (RTLS) technique distributes mechanical stress more evenly than traditional closure when closing a laparotomy wound, potentially reducing incisional hernia (IH) risk. We aimed to compare outcomes of RTLS versus standard closure techniques in patients undergoing laparotomy. Methods Systematic search
Rama H. G. Mikhail, Shahin Hajibandeh, Shahab Hajibandeh, Marty Smith, Ee Jun Ban, Rodney Jacobs, Siobhan C. McKay   +6 more
wiley   +1 more source

Efficacy of hyperthermic intraperitoneal chemotherapy in patients with epithelial ovarian cancer: a meta-analysis

International Journal of Hyperthermia, 2019
Objective: The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in epithelial ovarian cancer (EOC) is still controversial. Present analysis aims to evaluate the survival benefit of HIPEC in treatment of EOC patients. Methods: Articles related to
Qiwen Wu, Qianqian Wu, Jianying Xu, Xiaodong Cheng, Xinyu Wang, Weiguo Lu, Xiao Li   +6 more
doaj   +1 more source

Prognostic Factors and Nomogram‐Based Prediction Models for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis Undergoing Cytoreductive Surgery: A Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Colorectal cancer (CRC) with synchronous peritoneal metastasis (SPM) presents poor prognosis and complex treatment challenges. This study aimed to identify independent prognostic factors and develop nomogram‐based prediction models for overall survival (OS) and progression‐free survival (PFS) in CRC patients with SPM (CRC‐SPM ...
Xiaoxu Ge, Guanli Yang, Huiming Wu, Lei Liu, Ming Zhou, Akao Zhu, Xiangxing Kong, Jingjing Wu, Yeting Hu, Kefeng Ding, Lifeng Sun, Jian Wang   +11 more
wiley   +1 more source

A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options

Pleura and Peritoneum, 2021
Peritoneal metastasis (PM) is commonly observed in patients with colorectal cancer (CRC). The outcome of these patients is poor, with an average survival of only six months without therapy, which requires a better understanding of PM biology and new ...
Mönch Dina, Koch Jana, Maaß Annika, Janssen Nicole, Mürdter Thomas, Renner Philipp, Fallier-Becker Petra, Solaß Wiebke, Schwab Matthias, Dahlke Marc-H., Schlitt Hans J., Leibold Tobias   +11 more
doaj   +1 more source

Multimodal treatment of gastric cancer in the west: Where are we going? [PDF]

, 2015
The incidence of gastric cancer (GC) is decreasing worldwide, especially for intestinal histotype of the distal third of the stomach. On the contrary, proximal location and diffuse Lauren histotype have been reported to be generally stable over time.
Baiocchi, Gl, de Manzoni, G, Marrelli, D, Morgagni, P, Polom, K, Roviello, F   +5 more
core   +1 more source

Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

Cancers, 2021
Simple Summary Efficacy of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) depends on patient selection, tumor type, delivery technique, and treatment parameters such as temperature, carrier solution, type of ...
R. F. Helderman, Daan R Löke, P. Tanis, J. Tuynman, W. Ceelen, I. D. de Hingh, K. van der Speeten, N. Franken, A. Oei, H. P. Kok, J. Crezee   +10 more
semanticscholar   +1 more source

Placental Extracellular Vesicles Exhibit Reduced Neurogenic Potential Linked to Changes in Their miRNA Landscape Upon HCMV Infection

Journal of Extracellular Biology, Volume 5, Issue 1, January 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of maternal–foetal communication, regulating placental function and foetal development through the transfer of bioactive molecules. Although placental EVs play a crucial role in placental function during pregnancy, their contribution to foetal development, notably foetal brain, remains poorly ...
Charlène Martin, Hélène Martin, Mathilde Bergamelli, Lhorane Lobjois, Lucie Franco, Emma Bordes, Alexandra Benchoua, Stéphanie Balor, Diala Kantar, Etienne Coyaud, Frédéric Martins, Alexandre Favereaux, Cécile E. Malnou   +12 more
wiley   +1 more source

Transcriptomic Profiles for Elucidating Response of Bladder Intracavitary Hyperthermic Perfusion Chemotherapy in High‐Risk Nonmuscular Invasive Bladder Cancer

Cancer Medicine
Background Bladder intracavitary hyperthermic perfusion chemotherapy (HIPEC) is a promising treatment for non‐muscular invasive bladder cancer (NMIBC). However, the molecular mechanisms underlying the response to HIPEC remain poorly understood.
Zhicheng Huang, Tianhui Zhang, Jinghua Pan, Guihao Zhang, Linjun Jiang, Huiming Jiang, Pei Wan, Ying Peng, Wenchao Zou, Qinghua Liu, Nanhui Chen   +10 more
doaj   +1 more source

Effect of hyperthermia on improving neutrophil restoration after intraperitoneal chemotherapy

International Journal of Hyperthermia, 2019
Purpose: Intraperitoneal (IP) chemotherapy has several benefits but also can have severe hematologic side effects. We compared the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) and conventional IP chemotherapy on bone marrow suppression ...
Wan-Chun Huang, Chao-Chih Wu, Yun-Ting Hsu, Chih-Long Chang   +3 more
doaj   +1 more source