Results 181 to 190 of about 120,668 (359)

Editorial: Development of in vitro toxicology methods using organoid systems and toxicogenomic approaches

Frontiers in Genetics, 2022
Toshio Imai, Yoshitaka Hippo
doaj   +1 more source

SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway

, 2022
Kun Fang, Sha Du, Dachuan Shen, Zhipeng Xiong, Ke Jiang, Dapeng Liang, Jianxin Wang, Huizhe Xu, Lulu Hu, Xingyue Zhai, Yuting Jiang, Zhiyu Xia, Chunrui Xie, Di Jin, Wei Cheng, Songshu Meng, Yifei Wang   +16 more
openalex   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

The hippo-YAP1/TEAD1-SLC7A5 axis: uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosis. [PDF]

Redox Rep
Yang J, Ma Z, Wan W, Yuan D, Li J, Wang Y, Wang B, Lyu G, Xun Y, Yu X.   +9 more
europepmc   +1 more source

Constructive Memory in Truth‐Telling for Reconciliation

Journal of Applied Philosophy, EarlyView.
ABSTRACT Truth‐telling has, in diverse contexts, been conceptualised as a vehicle for achieving reconciliation following injustice. As a social and political phenomenon, it involves the communication of narratives grounded in episodic memory. Such narratives may fail to reproduce the details of past events and may even include details that were not ...
Alberto Guerrero‐Velázquez, Stephen W. Enciso   +1 more
wiley   +1 more source

Integrative machine learning identifies a TEAD4-driven endothelial program shaping drug sensitivity and microvascular invasion in HCC. [PDF]

J Transl Med
Zhang P, Song H, Lin S, Zhu Y.
europepmc   +1 more source

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

Ryosuke Isotani, Masaki Igarashi, Masaomi Miura, Kyoko Naruse, Satoshi Kuranami, Manami Katoh, Seitaro Nomura, Toshimasa Yamauchi   +7 more
openalex   +1 more source

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, EarlyView.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source