Results 201 to 210 of about 114,310 (305)

<i>IGF2BP3</i>-mediated stabilization of <i>RHOA</i> mRNA promotes osteosarcoma proliferation via Hippo signaling. [PDF]

Transl Cancer Res
Wu J, Xia J, Tao Y, Weng Y.
europepmc   +1 more source

AKR1C3 Binds β‐Trcp to Promote the Degradation of TFRC to Protect Hepatocellular Carcinoma From Ferroptosis

Cancer Science, EarlyView.
In this study, we show that aldo‐keto reductase family 1 member C3 (AKR1C3), a protein highly expressed in ferroptosis resistant hepatocellular carcinoma cells, acts as an enzyme‐independent scaffold protein by promoting the nuclear export of β‐transducin repeat protein (β‐TrCP) and its binding to transferrin receptor (TFRC) in an enzyme‐independent ...
Lei Qi, Jingyi Hua, Di Pan, Wanwan Yang, Geng Tian, Fangyu Ye, Lingxiang Liu, Yuhan Mao, Qinglong Guo, Haopeng Sun, Li Zhao   +10 more
wiley   +1 more source

Clostridioides difficile TcdB induces expression of its receptor (CSPG4) through a noncanonical Hippo signaling mechanism. [PDF]

J Biol Chem
Larabee JL, Donald EJ, Sukhadia AA, Shadid TM, Miller SJ, Ballard JD.   +5 more
europepmc   +1 more source

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway

Cancer Science, EarlyView.
This study provides the first comprehensive characterization of the functional impact, and mechanistic role of FAT4 in MM. Our findings highlight the tumor‐suppressive role of FAT4 in MM and uncover a novel mechanism by which FAT4 regulates the Hippo/YAP pathway.
Lina Zhang, Na Shen, Xin Cheng, Qinglin Shi, Lijuan Chen, Xuxing Shen   +5 more
wiley   +1 more source

Cell density-dependent nuclear-cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1-mediated transcription. [PDF]

FEBS Lett
Eom J, Jang J, Park JS, Kang YK.
europepmc   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Loss of the DCHS1 Intracellular Domain Expands Neurogenic Proliferation and Generates Van Maldergem-like Neurodevelopmental Defects. [PDF]

Cells
Byerly K, Wolfe C, Brei M, Parris H, Fisher S, Alston A, Dong H, Chen P, Yao H, Tang F, Guz J, Dooley S, Nelson T, Loizzi B, Phookan R, Gensemer C, Patel S, Norris RA.   +17 more
europepmc   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Cytosolic nucleic acid sensing triggers type I interferon activation via the Hippo kinase LATS1. [PDF]

J Biol Chem
Nass T, Reichardt AD, Aliyari SR, Tom E, LeMunyan G, Parvatiyar MS, Cheng G, Parvatiyar K.   +7 more
europepmc   +1 more source

Impact of G‐CSF on Donor TCR Clonal Diversity and T Cell Function During Donor HSC Mobilisation

Cell Proliferation, EarlyView.
In this study, we found that G‐CSF mobilisation caused a reduction in TCR clonal diversity and down‐regulation of T‐cell function in donors. This may be one of the reasons for the low incidence of GVHD mediated by G‐CSF after allo‐HSCT. Source: Created in BioRender. Li https://BioRender.com/otownki.
Xinye Li, Zhixi Chen, Jie Chen, Xingwei Zhang, Jiamian Zheng, Zirui Liu, Meixue Pan, Yue Li, Bo Yu, Shaohua Chen, Jing Lai, Xianfeng Zha, Liye Zhong, Yikai Zhang, Yangqiu Li   +14 more
wiley   +1 more source