Results 191 to 200 of about 114,310 (305)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Correction: The impact of inhibiting the Hippo signaling pathway effector molecule YAP1 on in vitro glioblastoma and glioblastoma stem cells. [PDF]

Sci Rep
Ozates NP, Bagca BG, Asik A, Gunduz C, Akin H, Avci CB.   +5 more
europepmc   +1 more source

TNF Pathway‐Mediated Tolerogenic T‐Cell Trajectory Driven by Allergen Immunotherapy

Allergy, EarlyView.
The study shows that AIT re‐establishes local immune equilibrium by restoring Th17/Treg balance, while circulating Th17 cells remain functionally impaired. The transition from pro‐inflammatory Th17 to regulatory T cell states during AIT identifies Tr17 cells as an intermediate cell population.
Helen S. Charles, Amr A. Gabr, Shu‐Hung Wang, Ulrich M. Zissler, Sonja Heine, Alexander Heldner, Sebastian Kotz, Lisa Pechtold, Lynn S. zur Bonsen, Dimitrii Pogorelov, Josephine Kau, Mirjam Plaschke, Miriam Hills, Ferdinand Guerth, Madlen Oelsner, Caspar Ohnmacht, Francesca Alessandrini, Simon Blank, Adam M. Chaker, Carsten B. Schmidt‐Weber, Constanze A. Jakwerth   +20 more
wiley   +1 more source

Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour. [PDF]

Cell Oncol (Dordr)
Salguero-Aranda C, Lobo-Selma L, Beltrán-Povea A, Baute-González S, Gilabert-Prieto P, Jordán-Perez C, Fernández-Juárez JA, Amaral AT, Rodríguez R, Díaz-Martín J, de Álava E.   +10 more
europepmc   +1 more source

Morphometric and Paleobiological Insights Into Pleistocene Sicilian Wolf Populations

Acta Zoologica, EarlyView.
ABSTRACT The Pleistocene wolves (Canis lupus) from Sicily represent one of the few known insular populations of this species from that time period. Despite their potential relevance for understanding carnivore adaptations in insular contexts, no dedicated study has previously investigated their morphology and evolutionary significance.
Domenico Tancredi, Carolina Di Patti, Sabrina Lo Brutto, Matteo Cammarata   +3 more
wiley   +1 more source

O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy. [PDF]

Cell Death Dis
Dai S, Wan X, Xia L, Xu L, Xie C, Wang G, Tang J.   +6 more
europepmc   +1 more source

Drilling the Marathousa palaeo‐lake in Greece (Peloponnese): inferring the environmental context of a Middle Pleistocene archaeological site

Boreas, EarlyView.
The Megalopolis Basin is located in the central Peloponnese (Greece), a region that is situated along one of the primary Pleistocene biogeographical corridors for intracontinental hominin migration. The basin comprises several hundred metres of Plio‐Pleistocene sediments alternating between clastics and lignites.
Ines J. E. Bludau, Bernd Wagner, Uwe Kirscher, Maria Schindler, Charlotte Zachow, Johannes Schmidt, Niklas Leicher, Giovanni Muttoni, Serena Perini, Vangelis Tourloukis, Eleni Panagopoulou, Panagiotis Karkanas, Katerina Harvati, Annett Junginger   +13 more
wiley   +1 more source

MAP17 Enhances Chemoresistance and Tumorigenicity of Glioblastoma‐Initiating Cells via the Canonical NF‐кB Pathway

Cancer Science, EarlyView.
MAP 17 is identified as highly expressed in TMZ‐resistant glioblastoma‐initiating cells (GICs). MAP17 enhances GIC proliferation, TMZ resistance, and tumorigenicity through NF‐κB/RELA‐dependent BCL2 upregulation. ABSTRACT Glioblastoma (GBM) is the most common malignant brain tumor in adults.
Shenshen Dou, You Lee Son, Toru Kondo
wiley   +1 more source

Oxaliplatin upregulates Cyr61 expression by inhibiting the Hippo-YAP pathway which contributes to drug resistance of colorectal cancer cells. [PDF]

Discov Oncol
Lu P, Zheng C, Zhang J, Zhu X, Chen X, Zhang J, Cao Y, Huang Z.   +7 more
europepmc   +1 more source

Macrophage‐Specific Loss of Stearoyl‐CoA Desaturase 1 Promotes Colon Cancer by Enhancing M2 TAM Polarization

Cancer Science, EarlyView.
Macrophage‐specific Scd1 deletion accelerates colon cancer progression by suppressing the Hippo‐YAP pathway, which drives immunosuppressive M2 polarization and induces CD8+ T cell exhaustion. Pharmacological YAP activation with TT‐10 effectively reverses this microenvironment, highlighting a promising target for immunotherapy. ABSTRACT In colon cancer (
Qing You, Jiaqi Du, Ziran Wei, Yandong Liu, Weijun Wang, Wenchao Gao   +5 more
wiley   +1 more source