Results 61 to 70 of about 120,668 (359)

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. [PDF]

, 2015
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes.
A Kapoor, A Krapp, A Rada-Iglesias, A Sawada, A-C Binot, AF Hezel, AJ Saldanha, B Zhao, B Zhao, C Cortijo, C Haumaitre, C Trapnell, CHH Cho, CY McLean, DA Stoffers, DW Huang, E Kroon, E Rodríguez-Seguel, EF Chiang, F Argenton, F Esni, F Supek, FC Lynn, FC Pan, H Fang, H Fang, H Lango Allen, I Morán, I Rooman, J Bessa, J van Arensbergen, JM Oliver-Krasinski, K Kawakami, K Piper, K Piper, K Skouloudaki, KJ Gaulton, KM Petzold, KS Zaret, L Elghazi, L Pasquali, M Borowiak, M Carrasco, M Gannon, MA Maestro, MC Whitlock, MF Offield, MJL de Hoon, MN Weedon, MP Creyghton, N Bardeesy, N Gao, NM George, P Jacquemin, PA Seymour, R O’Rahilly, R Xie, RE Jennings, RF Luco, S Gupta, S Heinz, S Xuan, T Derrien, T Jowett, W Zhang, WA Whyte, Y Fujitani, Y Liu-Chittenden   +67 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Chest wall restriction device for modeling respiratory challenges and dysfunction

Frontiers in Medical Engineering
Breathing relies on unrestricted movement of the chest wall to maintain O2 and CO2 balance. Understanding the effects of chest and abdominal restrictions on respiratory function is critical for studying conditions such as respiratory diseases, extreme ...
Victoria Ribeiro Rodrigues, Lizuannette Mejia, Rafael G. Zucchi, Paul W. Davenport, Nicholas J. Napoli   +4 more
doaj   +1 more source

The Role of Mst1 in Lymphocyte Homeostasis and Function

Frontiers in Immunology, 2018
The Hippo pathway is an evolutionarily conserved pathway crucial for regulating tissue size and for limiting cancer development. However, recent work has also uncovered key roles for the mammalian Hippo kinases, Mst1/2, in driving appropriate immune ...
Jiali Cheng, Yukai Jing, Danqing Kang, Lu Yang, Jingwen Li, Ze Yu, Zican Peng, Xingbo Li, Yin Wei, Quan Gong, Quan Gong, Richard J. Miron, Yufeng Zhang, Chaohong Liu   +13 more
doaj   +1 more source

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. [PDF]

, 2015
YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size.
Guan, Kun-Liang, Hansen, Carsten Gram, Kim, Soohyun, Kim, Young Chul, Lim, Dae-Sik, Meng, Zhipeng, Mo, Jung-Soon, Park, Hyun Woo   +7 more
core  

Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation [PDF]

, 2022
Jubina Balan Venghateri, Bareket Dassa, David Morgenstern, Michal Shreberk‐Shaked, Moshe Oren, Benjamin Geiger   +5 more
openalex   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Ecofeminism and Cultural-Value System in Traditional Paddy Farming: A Folklore from West Borneo

Celt: A Journal of Culture, English Language Teaching & Literature
Ne’ Balungkur represents the inherited living value of traditional paddy farming lived by Dayak Kanayatn. Concerning the ecofeminism ideology, this study aims to reveal the existence of women and nature in traditional paddy farming in Ne’ Balungkur ...
Antonius Setyawan Sugeng Nur Agung, Monika Widyastuti Surtikanti, Wedhowerti Wedhowerti   +2 more
doaj   +1 more source

Hippo signalling during development [PDF]

Development, 2019
ABSTRACT The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’
John Robert Davis, Nicolas Tapon
openaire   +3 more sources

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, EarlyView.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source