Results 221 to 230 of about 990,791 (254)

MYC in Oncogenesis and Therapeutic Implications

MedComm, Volume 7, Issue 8, August 2026.
The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang, Li Wei, Cuiping Tang, Peilong Lai, Wenbin Zhong, Hua You   +5 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Hippo Signaling Pathway Involvement in Osteopotential Regulation of Murine Bone Marrow Cells Under Simulated Microgravity. [PDF]

Cells
Tyrina E, Yakubets D, Markina E, Buravkova L.   +3 more
europepmc   +1 more source

A Vegan Diet Epigenetically Modulates Inflammatory Pathways and Biological Aging: Genome‐Wide DNA Methylation Analysis of a One‐Month Isocaloric Vegan Versus Meat‐Rich Dietary Intervention

MedComm, Volume 7, Issue 8, August 2026.
This study provides comprehensive insights into the epigenetic impacts of dietary interventions, specifically contrasting the effects of a vegan diet (VD) with a meat‐rich diet (MR) on DNAm profiles and their potential health implications. Dietary habits can significantly reshape the epigenomic landscape within 1 month, with the VD exerting a more ...
L. Karbacher, Jerome Mertens, S. Kowarschik, A. K. Lederer, M. Ku, R. Huber, Maximilian Andreas Storz   +6 more
wiley   +1 more source

Mst1/Hippo signaling pathway drives isoproterenol-induced inflammatory heart remodeling. [PDF]

Int J Med Sci
He X, Huang S, Yu C, Chen Y, Zhu H, Li J, Chen S.   +6 more
europepmc   +1 more source

Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion. [PDF]

J Tradit Complement Med
Xia L, Huang S, Huang H, Han X, Dong L, Xia Y.   +5 more
europepmc   +1 more source

Interaction of noncoding RNAs with hippo signaling pathway in cancer cells and cancer stem cells. [PDF]

Noncoding RNA Res
Abedimanesh S, Safaralizadeh R, Jahanafrooz Z, Najafi S, Amini M, Nazarloo SS, Bahojb Mahdavi SZ, Baradaran B, Jebelli A, Mokhtarzadeh AA.   +9 more
europepmc   +1 more source

XMU-MP-1, Inhibitor of STE20-like MST1/2 Kinases of the Hippo Signaling Pathway, Suppresses the Cell Cycle, Activates Apoptosis and Autophagy, and Induces Death of Hematopoietic Tumor Cells. [PDF]

Pharmaceuticals (Basel)
Stepchenko AG, Georgieva SG, Pankratova EV.   +2 more
europepmc   +1 more source

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CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.

European Journal of Pharmacology, 2022
Diabetic cardiomyopathy (DCM), as a major complication of diabetic patients, can cause myocardial metabolic remodeling and lead to severe and irreversible cardiac dysfunction.
Yingchun Shao, Mengmeng Li, Qingbo Yu, Manyu Gong, Yanying Wang, Xuewen Yang, Liheng Liu, Dongping Liu, Zhongyue Tan, Yuanyuan Zhang, Yu-Chun Qu, Haodong Li, Yaqi Wang, Lei Jiao, Y. Zhang   +14 more
semanticscholar   +1 more source

Alveolar macrophage-derived exosomal tRF-22-8BWS7K092 activates Hippo signaling pathway to induce ferroptosis in acute lung injury.

International Immunopharmacology, 2022
BACKGROUND Alveolar macrophages (AMs) play a demonstrative role in acute lung injury (ALI). Exosomes act as signaling molecules to regulate cell-to-cell communication by releasing RNAs. Transfer RNA-derived fragments (tRFs) possess potential functions in
Weixi Wang, Lin Zhu, Huiting Li, W. Ren, Ran Zhuo, Chencheng Feng, Yuting He, Yu Hu, Cong Ye   +8 more
semanticscholar   +1 more source