Results 211 to 220 of about 990,791 (254)

Hippo Pathway Regulation and Microenvironmental Cues Governing Human MSC Transition to Cancer‐Associated Fibroblasts

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are key drivers of tumor progression. This study examined how three‐dimensional (3D) culture, hypoxia, and cancer‐derived soluble factors influence the transformation of human mesenchymal stem cells (hMSCs) into inflammatory CAFs (iCAFs). hMSCs from bone marrow, placenta, and chorion were cultured in 2D, in
Pimjai Chingsuwanrote, Chanchao Lorthongpanich, Pakpoom Kheolamai, Ting Gang Chew, Chuti Laowtammathron, Sudjit Luanpitpong, Rangsun Parnpai, Surapol Issaragrisil   +7 more
wiley   +1 more source

Molecular dynamics simulations of a multicellular model with cell-cell interactions and Hippo signaling pathway. [PDF]

PLoS Comput Biol
Umegaki T, Moriizumi H, Ogushi F, Takekawa M, Suzuki T.   +4 more
europepmc   +1 more source

Small Extracellular Vesicle‐Derived Nidogen 1 Promotes HCC Carcinogenesis via Transglutaminase 3‐Mediated YAP/TAZ Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
NID1‐rich sEVs released by HCC cells are internalized by recipient cells, where the C‐terminal region of NID1 binds to and stabilizes TGM3. This activates integrin‐FAK/Src/AKT and Hippo‐YAP/TAZ signalling, thereby promoting HCC proliferation, colony formation, migration, invasion, tumour growth, and lung metastasis.
Cherlie Lot Sum Yeung, Le Cui, Jingyi Wang, Ching‐Ping Chan, Tung Him Ng, Charlotte Jiaqi Lai, Xiaowen Mao, Sze Keong Tey, Michael Shing Yan Huen, Judy Wai Ping Yam   +9 more
wiley   +1 more source

Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice. [PDF]

J Ovarian Res
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L.   +9 more
europepmc   +1 more source

Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu Arteritis

Journal of Extracellular Biology, Volume 5, Issue 8, August 2026.
ABSTRACT Takayasu arteritis (TAK) is a large‐vessel vasculitis that can lead to aneurysmal dilation, yet reliable circulating biomarkers for vascular remodelling remain lacking. Extracellular vesicles (EVs) carry miRNAs implicated in vascular biology, but their relevance to TAK has not been fully explored. Circulating EVs were isolated from serum of 54
Kohei Kawajiri, Shun Nakagama, Tetsuo Sasano, Yasuhiro Maejima   +3 more
wiley   +1 more source

Lead exposure promotes NF2-wildtype meningioma cell proliferation through the Merlin-Hippo signaling pathway. [PDF]

Environ Health Prev Med
Zhang N, Shen X, Yu Y, Xu L, Wang Z, Zhu J.   +5 more
europepmc   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Exploring the effects of Hippo signaling pathway on rumen epithelial proliferation. [PDF]

BMC Vet Res
Yang B, Xu Z, Qin Y, Peng Y, Luo Y, Wang J.   +5 more
europepmc   +1 more source

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

Expression of Concern: Hippo signaling pathway is altered in Duchenne muscular dystrophy. [PDF]

PLoS One
PLOS ONE Editors.
europepmc   +1 more source