Results 211 to 220 of about 33,422 (243)

The long noncoding RNA ELFN1-AS1 promotes gastric cancer growth and metastasis by interacting with TAOK1 to inhibit the Hippo signaling pathway. [PDF]

Cell Death Discov
Wang Y, Shen K, Cheng Q, Zhou X, Liu K, Xiao J, Hu L.   +6 more
europepmc   +1 more source

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Modularity in the Hippo signaling pathway

Trends in Biochemical Sciences, 2010
Metazoans have evolved several pathways to regulate the size of organs and ultimately that of organisms. One such pathway is known as Salvador-Warts-Hippo, or simply Hippo. Research on the Hippo pathway has grown exponentially during the past 8 years, revealing a complex signaling network.
Marius, Sudol, Kieran F, Harvey
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The unfolding of the Hippo signaling pathway

Developmental Biology, 2022
The development of a functional organ requires not only patterning mechanisms that confer proper identities to individual cells, but also growth-regulatory mechanisms that specify the final size of the organ. At the turn of the 21st century, comprehensive genetic screens in model organisms had successfully uncovered the major signaling pathways that ...
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The Hippo Signaling Pathway in Regenerative Medicine

2018
The major role of Hippo signaling is to inhibit their downstream effectors YAP/TAZ for organ size control during development and regeneration (Nat Rev Drug Discov 13(1):63-79, 2014; Dev Cell 19(4):491-505, 2010; Cell 163(4):811-828, 2015). We and others have demonstrated that the genetic disruption of kinases Mst1 and Mst2 (Mst1/2), the core components
Lixin, Hong, Yuxi, Li, Qingxu, Liu, Qinghua, Chen, Lanfen, Chen, Dawang, Zhou   +5 more
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Hippo Signaling Pathway in Cancer Stem Cell

2023
In recent years, how to inhibit the proliferation of tumor cells and the expression of stem genes has become one of the focuses of scientists in treating cancer. Cancer stem cell (CSC) is a kind of cell group with self-renewal ability in tumors, and is considered as one of the driving factors in the process of tumorigenesis. The Hippo signaling pathway
Wang Shen, Weijian ZHAO, Hongting XU, Xiangqian XIAO   +3 more
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Angiomotin family proteins in the Hippo signaling pathway

BioEssays
AbstractThe Motin family proteins (Motins) are a class of scaffolding proteins consisting of Angiomotin (AMOT), AMOT‐like protein 1 (AMOTL1), and AMOT‐like protein 2 (AMOTL2). Motins play a pivotal role in angiogenesis, tumorigenesis, and neurogenesis by modulating multiple cellular signaling pathways.
Yu Wang, Fa‐Xing Yu
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The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies

Journal of Cellular Physiology, 2020
AbstractOsteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation of cellular functions.
Emel Rothzerg, Evan Ingley, Benjamin Mullin, Wei Xue, David Wood, Jiake Xu   +5 more
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Targeting YAP and Hippo signaling pathway in liver cancer

Expert Opinion on Therapeutic Targets, 2010
The Hippo signaling pathway plays pivotal roles in controlling both cell growth and organ size, emerging as a new paradigm in tumor suppression. Yes-associated protein (YAP) functions as a potent transcription co-activator and is a major downstream target tightly regulated by the Hippo pathway.
Poon, RT, Liu, AM, Xu, MZ, Chen, J, Luk, JM   +4 more
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The Hippo signal transduction pathway in soft tissue sarcomas

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2015
Sarcomas are rare cancers (≈1% of all solid tumours) usually of mesenchymal origin. Here, we review evidence implicating the Hippo pathway in soft tissue sarcomas. Several transgenic mouse models of Hippo pathway members (Nf2, Mob1, LATS1 and YAP1 mutants) develop various types of sarcoma.
Abdalla D. Mohamed, Annie M. Tremblay, Graeme I. Murray, Henning Wackerhage   +3 more
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Hippo signaling pathway in liver tissue homeostasis.

Yi chuan = Hereditas, 2017
Liver cancer and diseases have become the leading cause of deaths in China. Liver diseases including liver failure and liver cancer can be genetic or caused by a variety of factors that damage the liver, such as viruses and alcohol overdose. However, the underlying mechanisms that maintain liver homeostasis remain unclear.
Yu-xi, Li, Jun-hong, Li, Da-wang, Zhou
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