Results 1 to 10 of about 1,592,864 (188)

The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer [PDF]

MedComm
Yes‐associated protein (YAP) plays a central role in the Hippo pathway, primarily governing cell proliferation, differentiation, and apoptosis. Its significance extends to tumorigenesis and inflammatory conditions, impacting disease initiation and ...
Bing Zhong, Jintao Du, Feng Liu, Silu Sun   +3 more
doaj   +4 more sources

Yes-associated protein regulates autophagy to restore skin barrier function in atopic dermatitis [PDF]

Frontiers in Immunology
IntroductionAtopic dermatitis (AD) is characterized by skin barrier dysfunction and inflammation.This study explored the relationship between Yes-associated protein (YAP) expression, autophagy, and skin barrier dysfunction in AD.MethodsSkin samples from ...
Jinjing Jia, Xin Ma, Tongfei Wang, Siqi Ye, Fenggen Yan, Junfeng Liu, Hongyi Li, Dacan Chen, Xiumei Mo   +8 more
doaj   +2 more sources

Recent advances in the role of Yes-associated protein in dermatosis. [PDF]

Skin Res Technol, 2023
AbstractBackgroundDermatosis is a general term for diseases of the skin and skin appendages including scleroderma, psoriasis, bullous disease, atopic dermatitis, basal cell carcinoma, squamous cell carcinoma, and melanoma. These diseases affect millions of individuals globally and are a serious public health concern.
Jia X, He L, Yang Z.
europepmc   +3 more sources

Yes-associated protein 1 in cancer: bridging mechanical transduction and epigenetic regulation [PDF]

Cancer Biology & Therapy
Yes-associated protein 1 (YAP1) and its paralog TAZ serve as central mechanotransductive transcription coactivators that integrate mechanical cues from the extracellular matrix, such as stiffness and fluid shear stress, with epigenetic modifications to ...
Tingting Liu, Shuo Yu, Lu Zhang, Wenwen Ji, Guangdong Wang, Na Wang, Mengcong Li, Tinghua Hu, Zhihong Shi   +8 more
doaj   +2 more sources

Yes-associated protein induces age-dependent inflammatory signaling in the pulmonary endothelium. [PDF]

Am J Physiol Lung Cell Mol Physiol
AbstractAcute Lung Injury (ALI) causes the highly lethal Acute Respiratory Distress Syndrome (ARDS) in children and adults, for which therapy is lacking. Children with Pediatric ARDS (PARDS) have a mortality rate that is about half of adults with ARDS.
Emin MT, Dubuisson AM, Sujin Kumar P, Knutsen C, Alvira CM, Hough RF.   +5 more
europepmc   +3 more sources

Expression of Yes-associated protein in endothelial cells of human corneas before and after storage in organ culture [PDF]

Scientific Reports
The cornea, the anterior meniscus-shaped transparent and refractive structure of the eyeball, is the first mechanical barrier of the eye. Its functionality heavily relies on the health of its endothelium, its most posterior layer.
Hanielle Vaitinadapoulé, Olfa Ben Moussa, Corantin Maurin, Inès Aouimeur, Chantal Perrache, Justin Thomas, Pierre Forestier, Emmanuel Crouzet, Zhiguo He, Philippe Gain, Gilles Thuret, Frédéric Mascarelli   +11 more
doaj   +2 more sources

Yes-associated protein plays oncogenic roles in human sporadic colorectal adenomas. [PDF]

Carcinogenesis
Abstract The role of Hippo-Yes-associated protein (YAP) in human colorectal cancer (CRC) presents contradictory results. We examined the function of YAP in the early stages of CRC by quantitatively measuring the expression of phospho-YAPS127 (p-YAP) and five APC-related proteins in 145 sporadic adenomas from the Tennessee Colorectal ...
Fan L, Guo X, Washington MK, Shi J, Ness RM, Liu Q, Wen W, Huang S, Liu X, Cai Q, Zheng W, Coffey RJ, Shrubsole MJ, Su T.   +13 more
europepmc   +3 more sources

YAP1 (Yes-associated protein 1, 65kDa) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on YAP1 (Yes-associated protein 1, 65kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
Di, Agostino S, Strano, S, Blandino, G
openaire   +2 more sources

The Hippo-Yes Association Protein Pathway in Liver Cancer [PDF]

Gastroenterology Research and Practice, 2013
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the third leading cause of cancer mortality. Despite continuing development of new therapies, prognosis for patients with HCC remains extremely poor. In recent years, control of organ size becomes a hot topic in HCC development.
Lu Jie, Wang Fan, Dai Weiqi, Zhou Yingqun, Xu Ling, Shen Miao, Cheng Ping, Guo Chuanyong   +7 more
openaire   +4 more sources

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis [PDF]

Cell Death & Disease, 2010
Yes-associated protein (YAP) regulates DNA damage and chemosensitivity, as well as functioning as a pro-growth, cell size regulator. For both of its roles, regulation by phosphorylation is crucial. We undertook an in vitro screen to identify novel YAP kinases to discover new signaling pathways to better understand YAP's function. We identified JNK1 and
Tomlinson, V, Gudmundsdottir, K, Luong, P, Leung, K-Y, Knebel, A, Basu, S   +5 more
openaire   +2 more sources