Results 21 to 30 of about 1,592,983 (303)
Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity [PDF]
Journal of Biological Chemistry, 2001 Specific protein-protein interactions are involved in a large number of cellular processes and are mainly mediated by structurally and functionally defined domains. Here we report that the nuclear phosphoprotein p73 can engage in a physical association with the Yes-associated protein (YAP).
Giovanni Blandino +9 more
openaire +3 more sources
The Hippo Pathway and Viral Infections
Frontiers in Microbiology, 2020 The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang +5 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: Adipose tissue is a very dynamic metabolic organ that plays an essential role in regulating whole-body glucose homeostasis. Dysfunctional adipose tissue hypertrophy with obesity is associated with fibrosis and type 2 diabetes.
Daniel J. Han +9 more
doaj +1 more source
Effect of Pulsatile and Continuous Flow on Yes-Associated Protein [PDF]
International Journal of Angiology, 2014 Yes-associated protein (YAP) is a mechanosignaling protein that relays mechanical information to the nucleus by changing its level of phosphorylation. We hypothesize that different flow patterns show differential effect on phosphorylated YAP (pYAP) (S127) and total YAP and could be responsible for flow dependent localization of atherosclerosis ...
Gautham, Chitragari +3 more
openaire +2 more sources
Molecular Oncology, 2021 Epithelial–mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor microenvironment plays an important role in driving metastasis of the malignant tumor.
Hongchi Yu +10 more
doaj +1 more source
Computerized Protein Modeling and Molecular Docking Analysis of Human Proto Oncogene Tyrosine Protein Kinase YES for Discovery of Novel Lead Molecules [PDF]
, 2010 Human proto-oncogene tyrosine-protein kinase YES (YES) is a non receptor kinase belongs to Src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.
Amineni Umamaheswari +2 more
core +2 more sources
Expression of PKCι/YAP1 in Cervical Cancer and Its Clinical Significance
Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the role of PKCι, YAP1 and high-risk HPV infection in the local immune microenvironment of cervical cancer. Methods We chose 80 cases of normal tissue of the cervix (NCT), cervical low-grade squamous intraepithelial lesion (LSIL),
CHEN Shengmin +3 more
doaj +1 more source
Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]
, 2016 BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S +13 more
core +1 more source
Hedgehog regulates yes‐associated protein 1 in regenerating mouse liver [PDF]
Hepatology, 2016 Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity to change within individual liver cells, and that coordinate proliferative activity among ...
Marzena, Swiderska-Syn +6 more
openaire +2 more sources
Yes-Associated Protein Expression Is Correlated to the Differentiation of Prostate Adenocarcinoma [PDF]
Journal of Pathology and Translational Medicine, 2017 Background Yes-associated protein (YAP) in the Hippo signaling pathway is a growth control pathway that regulates cell proliferation and stem cell functions.
Myung-Giun Noh +4 more
doaj +1 more source