Results 11 to 20 of about 1,592,983 (303)

Expression of Yes-associated protein in common solid tumors [PDF]

Human Pathology, 2008
The Hippo signaling pathway is a highly conserved potent regulator of cell growth, division, and apoptosis. Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a highly conserved component of this pathway in mammalian systems. In humans, amplification of the chromosome region containing the YAP gene (11q22) has been reported in ...
Angela A, Steinhardt, Mariana F, Gayyed, Alison P, Klein, Jixin, Dong, Anirban, Maitra, Duojia, Pan, Elizabeth A, Montgomery, Robert A, Anders   +7 more
openaire   +4 more sources

Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma [PDF]

Cancer, 2009
AbstractBACKGROUND:Yes‐associated protein (YAP), a downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse hepatocellular carcinoma (HCC) model. The objective of the current study was to investigate the clinical significance of YAP in HCC and its prognostic values in predicting survival and tumor ...
Zender, L, Lowe, SW, Chan, YT, Xu, MZ, Lee, NPY, Yao, TJ, Ng, IOL, Luk, JM, Poon, RTP   +8 more
openaire   +6 more sources

Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival. [PDF]

Signal Transduction and Targeted Therapy, 2018
Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious treatment modalities. Elucidation of signaling mechanisms that will lead to the identification of novel targets for therapy and chemoprevention is urgently needed ...
Eibl, Guido, Rozengurt, Enrique, Sinnett-Smith, James   +2 more
core   +4 more sources

Deficiency of Yes-Associated Protein Induces Cataract in Mice [PDF]

Aging and disease, 2019
Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract.
He, Qing, Gao, Yuhao, Wang, Tongxing, Zhou, Lujun, Zhou, Wenxia, Yuan, Zengqiang   +5 more
openaire   +2 more sources

LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP

Cell Communication and Signaling, 2020
Background LOX-like 1 (LOXL1) is a lysyl oxidase, and emerging evidence has revealed its effect on malignant cancer progression. However, its role in colorectal cancer (CRC) and the underlying molecular mechanisms have not yet been elucidated.
Lin Hu, Jing Wang, Yunliang Wang, Linpeng Wu, Chao Wu, Bo Mao, E. Maruthi Prasad, Yuhong Wang, Y. Eugene Chin   +8 more
doaj   +1 more source

Glucocorticoids activate Yes-associated protein in human vocal fold fibroblasts

Experimental Cell Research, 2021
Fibrosis of the vocal folds poses a substantive clinical challenge potentially underlying the rapid proliferation of direct steroid injections into the upper airway. The variable clinical response to glucocorticoids (GCs) in the vocal folds is likely related to diversity inherent to GCs and patient-specific, and upstream, cell-specific responses to GCs.
Ryosuke, Nakamura, Renjie, Bing, Carina P, Doyle, Michael J, Garabedian, Ryan C, Branski   +4 more
openaire   +2 more sources

Role of yes-associated protein in resistance of HER2+ breast cancer to lapatinib

Di-san junyi daxue xuebao, 2020
Objective To construct a lapatinib-resistant breast cancer cell line, and to study the role and underlying mechanism of yes-associated protein (YAP) in Hippo signaling pathway in the process.
CHEN Peng, XU Ting, GUO Dan, HUANG Jiayi
doaj   +1 more source

Modulation of the hippo-YAP pathway by cyclic stretch in rat type 2 alveolar epithelial cells—a proof-of-concept study

Frontiers in Physiology, 2023
Background: Mechanical ventilation (MV) is a life supporting therapy but may also cause lung damage. This phenomenon is known as ventilator-induced lung injury (VILI).
Xi Ran, Xi Ran, Sabine Müller, Coy Brunssen, Robert Huhle, Martin Scharffenberg, Christian Schnabel, Thea Koch, Marcelo Gama de Abreu, Marcelo Gama de Abreu, Marcelo Gama de Abreu, Henning Morawietz, Jorge M. C. Ferreira, Jakob Wittenstein   +13 more
doaj   +1 more source

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma [PDF]

Oncogene, 2016
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of inflammation and profound immune suppression. Here we identify Yes-associated protein (Yap) as a critical regulator of the immunosuppressive microenvironment in both mouse and human PDAC.
Murakami, Shigekazu, Shahbazian, David, Surana, Rishi, Zhang, Weiying, Chen, Hengye, Graham, Garrett T., White, Shannon M., Weiner, Louis M., Yi, Chunling   +8 more
openaire   +2 more sources

Yes-associated protein contributes to magnesium alloy-derivedinflammation in endothelial cells [PDF]

Regenerative Biomaterials, 2022
Abstract Magnesium alloy (Mg alloy) has attracted massive attention in the potential applications of cardiovascular stents because of its good biocompatibility and degradability. However, whether and how the Mg alloy induces inflammation in endothelial cells remains unclear.
Yu, Hongchi, Hou, Zhe, Chen, Nuoya, Luo, Rifang, Yang, Li, Miao, Michael, Ma, Xiaoyi, Zhou, Lifeng, He, Fugui, Shen, Yang, Liu, Xiaoheng, Wang, Yunbing   +11 more
openaire   +2 more sources