Results 41 to 50 of about 1,592,983 (303)

Pyrroloquinoline quinone modulates YAP-related anti-ferroptotic activity to protect against myocardial hypertrophy

Frontiers in Pharmacology, 2022
Background: Pyrroloquinoline quinone (PQQ) has been reported to exhibit cardioprotective and antioxidant activities. Accordingly, this study was developed to explore the effects of PQQ treatment on myocardial hypertrophy and the underlying mechanism of ...
Jiabin Zhou, Jiabin Zhou, Tao Yu, Tao Yu, Gujie Wu, Gujie Wu, Peng Xu, Peng Xu, Chen Wang, Yiling Su, Yiling Su, Li Wang, Li Wang, Qi Lu, Qi Lu   +14 more
doaj   +1 more source

PADI6 Regulates Trophoblast Cell Migration-Invasion Through the Hippo/YAP1 Pathway in Hydatidiform Moles

Journal of Inflammation Research, 2021
Bo Huang,* Yating Zhao,* Lin Zhou,* Tingyu Gong, Jiawen Feng, Peilin Han, Jianhua Qian Department of Gynecology and Obstetrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, 310003, Zhejiang Province ...
Huang B, Zhao Y, Zhou L, Gong T, Feng J, Han P, Qian J   +6 more
doaj  

Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression [PDF]

, 2015
Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma ...
Gersten, Adam, Gunn-Moore, Frank, Moleirinho, Susana, Prystowsky, Michael, Reynolds, Paul Andrew, Wang, Yanghua   +5 more
core   +1 more source

CCN1–Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis [PDF]

Molecular and Cellular Biology, 2019
Cellular communication network factor 1 (CCN1) is a dynamically expressed, matricellular protein required for vascular development and tissue repair. The CCN1 gene is a presumed target of Yes-associated protein (YAP), a transcriptional coactivator that regulates cell growth and organ size.
Sangmi Lee, Afruja Ahad, Michele Luu, Sohyun Moon, JoyAnn Caesar, Wellington V. Cardoso, Maria B. Grant, Brahim Chaqour   +7 more
openaire   +2 more sources

Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. [PDF]

, 2020
Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway.
Bin, Hu, Chan, Geraldine, Jablons, David M, Kyoyama, Hiroyuki, Li, Hui, Liu, Luwei, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Wang, Yucheng, Xu, Zhidong, Yang, Yi-Lin, You, Liang   +12 more
core  

Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. [PDF]

, 2018
Yes-associated protein (YAP) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine ...
Chan, Geraldine, Dai, Yuyuan, Hsu, Ping-Chih, Huang, Zhen, Jablons, David M, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Xu, Zhidong, Yang, Cheng-Ta, Yang, Yi-Lin, Yeh, Che-Chung, You, Joanna, You, Liang   +13 more
core   +1 more source

Association between C-reactive protein with all-cause mortality in ELSA-Brasil cohort [PDF]

, 2020
Background: High-sensitive C-reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and it may also be a marker of non-vascular mortality.
Alvim Matos, Sheila M., Azevedo, Douglas R. M., Barreto, Sandhi M., Cappuccio, Francesco P., Giatti Gonçalves, Luana, Griep, Rosane H., Ji, Chen, Maluf, Chams B., Miller, Michelle A., Ribeiro, Luiz P., Vidigal, Pedro G.   +10 more
core   +3 more sources

Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells.
Dhall, Deepti, Greene, Mark I, Morvaridi, Susan, Pandol, Stephen J, Wang, Qiang   +4 more
core   +1 more source

The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis

Frontiers in Medicine, 2023
ObjectivesThe mammalian target of Rapamycin (mTOR) is a metabolic master regulator of both innate and adaptive immunity; however, its exact role in stromal cell biology is unknown.
Brianne E. Barker, Brianne E. Barker, Megan M. Hanlon, Megan M. Hanlon, Viviana Marzaioli, Viviana Marzaioli, Conor M. Smith, Clare C. Cunningham, Clare C. Cunningham, Jean M. Fletcher, Jean M. Fletcher, Douglas J. Veale, Ursula Fearon, Ursula Fearon, Mary Canavan   +14 more
doaj   +1 more source

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity [PDF]

, 2015
SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood.
Biasiolo, Alessandra, Cannito, Stefania, Cillo, Umberto, Fasolato, Silvano, Gatta, Angelo, Martini, Andrea, Martini, Andrea, Morello, Elisabetta, Parola, Maurizio, Pontisso, Patrizia, Quarta, SANTINA MARIA, Ruvoletto, Mariagrazia, Simonato, Davide, Terrin, Liliana, Turato, Cristian, Villano, Gianmarco, Zanus, Giacomo   +16 more
core   +2 more sources