Results 51 to 60 of about 1,592,983 (303)

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

Frontiers in Oncology, 2021
Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature.
Aukie Hooglugt, Aukie Hooglugt, Miesje M. van der Stoel, Reinier A. Boon, Reinier A. Boon, Reinier A. Boon, Stephan Huveneers   +6 more
doaj   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Polydatin attenuates tubulointerstitial fibrosis in diabetic kidney disease by inhibiting YAP expression and nuclear translocation

Frontiers in Physiology, 2022
The activation of Yes-associated protein (YAP) pathway is mutually causal with the increase of extracellular matrix (ECM) stiffness. Polydatin (PD) has been proved to have anti-fibrosis effect in diabetic kidney disease (DKD), but it is still a mystery ...
Manlin He, Lan Feng, Yang Chen, Bin Gao, Yiwei Du, Lu Zhou, Fei Li, Fei Li, Hongbao Liu   +8 more
doaj   +1 more source

Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction [PDF]

, 2011
BACKGROUND: Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection.
Fang, K., Zhao, H., Changyue Sun, Lam, M.C., Chang, S., Zhang, K., Panda, G., Godinho, M., Martins Dos Santos, V.A.P., Wang, J.   +9 more
core   +2 more sources

Dual roles of yes-associated protein (YAP) in colorectal cancer

Oncotarget, 2017
Yes-associated protein (YAP) is a downstream effector molecule of a newly emerging tumour suppressor pathway called the Hippo pathway. YAP is a transcriptional co-activator and mis-expressed in various cancers, including colorectal cancer (CRC). Accumulating studies show that the high expression of nuclear YAP is linked with tumour progression and ...
Ou, Chunlin, Sun, Zhenqiang, Li, Shen, Li, Guiyuan, Li, Xiayu, Ma, Jian   +5 more
openaire   +3 more sources

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress

Journal of Experimental & Clinical Cancer Research, 2018
Background Hypoxia-inducible factor 1α (HIF-1α) is essential in hepatocellular carcinoma (HCC) glycolysis and progression. Yes-associated protein (YAP) is a powerful regulator and is overexpressed in many cancers, including HCC.
Xiaodong Zhang, Yan Li, Yingbo Ma, Liang Yang, Tao Wang, Xin Meng, Zhihong Zong, Xun Sun, Xiangdong Hua, Hangyu Li   +9 more
doaj   +1 more source

Yes-Associated Protein 1: Role and Treatment Prospects in Orthopedic Degenerative Diseases

Frontiers in Cell and Developmental Biology, 2020
The Hippo/yes-associated protein 1 signaling pathway is an evolutionarily conserved signaling pathway. This signaling pathway is primarily involved in the regulation of stem cell self-renewal, organ size and tissue regeneration by regulating cell ...
Wenqing Xie, Wenqing Xie, Wenfeng Xiao, Wenfeng Xiao, Kun Tang, Liyang Zhang, Yusheng Li, Yusheng Li   +7 more
doaj   +1 more source

Diversification of a protein kinase cascade: IME-2 is involved in nonself recognition and programmed cell death in Neurospora crassa. [PDF]

, 2012
Kinase cascades and the modification of proteins by phosphorylation are major mechanisms for cell signaling and communication, and evolution of these signaling pathways can contribute to new developmental or environmental response pathways.
Bueche, Joanna A, Glass, N Louise, Hutchison, Elizabeth A   +2 more
core   +2 more sources

Progesterone, via yes‐associated protein, promotes cardiomyocyte proliferation and cardiac repair [PDF]

Cell Proliferation, 2020
AbstractObjectivesThe mechanisms responsible for the postnatal loss of mammalian cardiac regenerative capacity are not fully elucidated. The aim of the present study is to investigate the role of progesterone in cardiac regeneration and explore underlying mechanism.Materials and MethodsEffect of progesterone on cardiomyocyte proliferation was analysed ...
Cong Lan, Nian Cao, Caiyu Chen, Shuang Qu, Chao Fan, Hao Luo, Andi Zeng, Cheng Yu, Yuanzheng Xue, Hongmei Ren, Liangpeng Li, Hongyong Wang, Pedro A. Jose, Zaicheng Xu, Chunyu Zeng   +14 more
openaire   +2 more sources

YAP regulates the liver size during the fasting-refeeding transition in mice

Acta Pharmaceutica Sinica B, 2023
Liver is the central hub regulating energy metabolism during feeding-fasting transition. Evidence suggests that fasting and refeeding induce dynamic changes in liver size, but the underlying mechanisms remain unclear.
Xuan Li, Shicheng Fan, Chenghui Cai, Yue Gao, Xinhui Wang, Yifei Zhang, Hangfei Liang, Huilin Li, Jie Yang, Min Huang, Huichang Bi   +10 more
doaj   +1 more source