Results 71 to 80 of about 1,592,983 (303)

Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients [PDF]

, 2016
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of
Edwards, J., Heng, J.S., Horgan, P.G., Leung, H.Y., Patek, S.C., Taylor, B., Underwood, M.A., Willder, J.M.   +7 more
core   +1 more source

β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis [PDF]

The American Journal of Pathology, 2019
Hepatoblastoma (HB), the most common pediatric primary liver neoplasm, shows nuclear localization of β-catenin and yes-associated protein 1 (YAP1) in almost 80% of the cases. Co-expression of constitutively active S127A-YAP1 and ΔN90 deletion-mutant β-catenin (YAP1-ΔN90-β-catenin) causes HB in mice.
Qian Min, Laura Molina, Jing Li, Adeola O. Adebayo Michael, Jacquelyn O. Russell, Morgan E. Preziosi, Sucha Singh, Minakshi Poddar, Madlen Matz-Soja, Sarangarajan Ranganathan, Aaron W. Bell, Rolf Gebhardt, Frank Gaunitz, Jinming Yu, Junyan Tao, Satdarshan P. Monga   +15 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Abnormal Expression of YAP Is Associated With Proliferation, Differentiation, Neutrophil Infiltration, and Adverse Outcome in Patients With Nasal Inverted Papilloma

Frontiers in Cell and Developmental Biology, 2021
BackgroundNasal inverted papilloma (NIP) is a common benign tumor. Yes-associated protein (YAP) is the core effector molecule of the Hippo pathway, which regulates the proliferation and differentiation of airway epithelium.
Tian Yuan, Tian Yuan, Rui Zheng, Xiang-min Zhou, Peng Jin, Zhi-qun Huang, Xiao-xue Zi, Qing-wu Wu, Wei-hao Wang, Hui-yi Deng, Wei-feng Kong, Hui-jun Qiu, Sui-zi Zhou, Qian-min Chen, Yan-yi Tu, Tao Li, Jing Liu, Jing Liu, Kai Sen Tan, Kai Sen Tan, Kai Sen Tan, Kai Sen Tan, Hsiao Hui Ong, Hsiao Hui Ong, Li Shi, Zhuang-gui Chen, Xue-kun Huang, Qin-tai Yang, De-yun Wang, De-yun Wang   +29 more
doaj   +1 more source

The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer [PDF]

, 2017
Background: The magnitude of the postoperative systemic inflammatory response (SIR), as evidenced by C-reactive protein (CRP), is associated with both short- and long-term outcomes following surgery for colorectal cancer.
Horgan, Paul G., McMillan, Donald C., Mcsorley, Stephen T., Roxburgh, Campbell S.D.   +3 more
core   +1 more source

Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Netrin-1 has been considered a pro-oncogene due to its oncogenic activity. However, the mechanism by which netrin-1 modulates cancer progression is not well understood. Here, we show that netrin-1 promotes cancer cell proliferation and migration through up-regulating Yes-associated protein (YAP), a downstream target of the Hippo ...
Qi, Qi, Li, Dean Y, Luo, Hongbo R, Guan, Kun-Liang, Ye, Keqiang   +4 more
openaire   +4 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer

Biomedicines, 2021
Liver cancer is one of the most common cancers worldwide, and its prevalence and mortality rate are increasing due to the lack of biomarkers and effective treatments.
Na-Hyun Lee, So Jung Kim, Jeongeun Hyun
doaj   +1 more source

Basal rot of narcissus : understanding pathogenicity in fusarium oxysporum f. sp. narcissi [PDF]

, 2019
Fusarium oxysporum is a globally distributed soilborne fungal pathogen causing root rots, bulb rots, crown rots and vascular wilts on a range of horticultural plants. Pathogenic F.
Armitage, Andrew D., Clarkson, John P., Handy, Claire, Harrison, Richard J., Hulin, Michelle T., Jackson, Alison C., Taylor, Andrew   +6 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source