Results 41 to 50 of about 33,422 (243)

The Hippo Signaling Pathway: The Trader of Tumor Microenvironment [PDF]

Frontiers in Oncology, 2021
The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metastasis.
Duo Yang, Na Zhang, Meihua Li, Tao Hong, Wei Meng, Taohui Ouyang   +5 more
openaire   +3 more sources

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

Cell Reports, 2020
Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored.
Lingli He, Liang Yuan, Wentao Yu, Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hang-zi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang, Lei Zhang   +17 more
doaj   +1 more source

Vamana Couples Fat Signaling to the Hippo Pathway [PDF]

Developmental Cell, 2016
The protocadherins Dachsous and Fat initiate a signaling pathway that controls growth and planar cell polarity by regulating the membrane localization of the atypical myosin Dachs. How Dachs is regulated by Fat signaling has remained unclear. Here we identify the vamana gene as playing a crucial role in regulating membrane localization of Dachs and in ...
Jyoti R, Misra, Kenneth D, Irvine
openaire   +2 more sources

Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. [PDF]

PLoS ONE, 2012
Epithelial cells are the major cell-type for all organs in multicellular organisms. In order to achieve correct organ size, epithelial tissues need mechanisms that limit their proliferation, and protect tissues from damage caused by defective epithelial ...
Shilpi Verghese, Indrayani Waghmare, Hailey Kwon, Katelin Hanes, Madhuri Kango-Singh   +4 more
doaj   +1 more source

Targeting the Hippo signalling pathway for cancer treatment [PDF]

Journal of Biochemistry, 2016
The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced ...
Keisuke, Nakatani, Tomohiko, Maehama, Miki, Nishio, Hiroki, Goto, Wakako, Kato, Hirofumi, Omori, Yosuke, Miyachi, Hideru, Togashi, Yohei, Shimono, Akira, Suzuki   +9 more
openaire   +2 more sources

Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila

Cell Death and Disease, 2022
Hippo signaling is a conserved mechanism for controlling organ growth. Increasing evidence suggests that Hippo signaling is modulated by various cellular factors for normal development and tumorigenesis.
Jung-Wan Mok, Kwang-Wook Choi
doaj   +1 more source

The Hippo pathway uses different machinery to control cell fate and organ size

iScience, 2021
Summary: The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that of R8 photoreceptor cells in the Drosophila eye, where Hippo specifies whether cells sense blue or green light.
Jonathan M. Pojer, Samuel A. Manning, Benjamin Kroeger, Shu Kondo, Kieran F. Harvey   +4 more
doaj   +1 more source

Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

Nature Communications
The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully ...
Yinan Yang, Huijing Zhou, Xiawei Huang, Chengfang Wu, Kewei Zheng, Jingrong Deng, Yonggang Zheng, Jiahui Wang, Xiaofeng Chi, Xianjue Ma, Huimin Pan, Rui Shen, Duojia Pan, Bo Liu   +13 more
doaj   +1 more source

The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System

Frontiers in Immunology, 2020
The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a critical role in controlling organ size, cancer development, and tissue regeneration.
Jinbo Cheng, Jinbo Cheng, Shukun Wang, Yuan Dong, Zengqiang Yuan   +4 more
doaj   +1 more source

Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor [PDF]

Clinical Cancer Research, 2015
Abstract The Salvador–Warts–Hippo pathway controls cell fate and tissue growth. The main function of the Hippo pathway is to prevent YAP and TAZ translocation to the nucleus where they induce the transcription of genes involved in cell proliferation, survival, and stem cell maintenance.
Ana, Sebio, Heinz-Josef, Lenz
openaire   +2 more sources