Results 41 to 50 of about 34,290 (249)
The Hippo Signaling Pathway in Cardiac Development and Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2019 Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity. Thus, loss of cardiomyocytes from injury or diseases in adults could lead to heart failure.
Masum M. Mia +2 more
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Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. [PDF]
PLoS ONE, 2012 Epithelial cells are the major cell-type for all organs in multicellular organisms. In order to achieve correct organ size, epithelial tissues need mechanisms that limit their proliferation, and protect tissues from damage caused by defective epithelial ...
Shilpi Verghese +4 more
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Dysregulation of the Hippo pathway signaling in aging and cancer
Pharmacological Research, 2019 Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life expectancy. In the near future, researchers will have to put even more effort into fighting these new challenges, one of which will be prevention of cancer while continuing to improve the aging process through this increased life ...
Yiu To Yeung +5 more
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Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways
Frontiers in Cell and Developmental Biology, 2020 Studies in yeast first delineated the function of Mob proteins in kinase pathways that regulate cell division and shape; in multicellular eukaryotes Mobs regulate tissue growth and morphogenesis.
Juan Carlos Duhart, Laurel A. Raftery
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Cell Death and Disease, 2022 Hippo signaling is a conserved mechanism for controlling organ growth. Increasing evidence suggests that Hippo signaling is modulated by various cellular factors for normal development and tumorigenesis.
Jung-Wan Mok, Kwang-Wook Choi
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The Hippo pathway uses different machinery to control cell fate and organ size
iScience, 2021 Summary: The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that of R8 photoreceptor cells in the Drosophila eye, where Hippo specifies whether cells sense blue or green light.
Jonathan M. Pojer +4 more
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Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis
Nature CommunicationsThe Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully ...
Yinan Yang +13 more
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The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System
Frontiers in Immunology, 2020 The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a critical role in controlling organ size, cancer development, and tissue regeneration.
Jinbo Cheng +4 more
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A growing role for the Hippo signaling pathway in the heart [PDF]
Journal of Molecular Medicine, 2017 Heart disease is a major cause of clinical morbidity and mortality, and a significant health and economic burden worldwide. The loss of functional cardiomyocytes, often a result of myocardial infarction, leads to impaired cardiac output and ultimately heart failure.
Yu, Zhang, Dominic P, Del Re
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