Results 41 to 50 of about 990,791 (254)

The Hippo Signaling Pathway: The Trader of Tumor Microenvironment

Frontiers in Oncology, 2021
The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the ...
Duo Yang, Na Zhang, MeiHua Li, T. Hong, W. Meng, T. Ouyang   +5 more
semanticscholar   +1 more source

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

Cell Reports, 2020
Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored.
Lingli He, Liang Yuan, Wentao Yu, Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hang-zi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang, Lei Zhang   +17 more
doaj   +1 more source

Research progress of the Hippo signaling pathway in renal cell carcinoma [PDF]

Asian Journal of Urology
Xiaolei Shi, Xinxin Gan, Yiren Yang
exaly   +2 more sources

Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways

Frontiers in Cell and Developmental Biology, 2020
Studies in yeast first delineated the function of Mob proteins in kinase pathways that regulate cell division and shape; in multicellular eukaryotes Mobs regulate tissue growth and morphogenesis.
Juan Carlos Duhart, Laurel A. Raftery
doaj   +1 more source

Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila

Cell Death and Disease, 2022
Hippo signaling is a conserved mechanism for controlling organ growth. Increasing evidence suggests that Hippo signaling is modulated by various cellular factors for normal development and tumorigenesis.
Jung-Wan Mok, Kwang-Wook Choi
doaj   +1 more source

The Hippo pathway uses different machinery to control cell fate and organ size

iScience, 2021
Summary: The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that of R8 photoreceptor cells in the Drosophila eye, where Hippo specifies whether cells sense blue or green light.
Jonathan M. Pojer, Samuel A. Manning, Benjamin Kroeger, Shu Kondo, Kieran F. Harvey   +4 more
doaj   +1 more source

Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

Nature Communications
The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully ...
Yinan Yang, Huijing Zhou, Xiawei Huang, Chengfang Wu, Kewei Zheng, Jingrong Deng, Yonggang Zheng, Jiahui Wang, Xiaofeng Chi, Xianjue Ma, Huimin Pan, Rui Shen, Duojia Pan, Bo Liu   +13 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Role of the Hippo pathway in autoimmune diseases

Experimental Gerontology
The immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play ...
Hui Kong, Juan-Juan Han, Dmitrii Gorbachev, Xin-An Zhang   +3 more
doaj   +1 more source

Hippo-YAP/TAZ pathway regulation: the crucial roles of lncRNAs in cancer

Animal Cells and Systems, 2023
The Hippo signaling pathway is a conserved signaling pathway that regulates cell proliferation, apoptosis, and differentiation and plays essential roles in the maintenance of organ size and tissue homeostasis.
Wonyi Jang, Mijung Im, Jungwook Roh, JiHoon Kang, Wanyeon Kim   +4 more
doaj   +1 more source