Results 21 to 30 of about 34,290 (249)

The Hippo Signaling Pathway in Pancreatic Cancer [PDF]

Anticancer Research, 2019
Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration. Dysregulation of the Hippo pathway has been recognized in a variety of human cancers, including pancreatic cancer. YES-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the two major downstream effectors of the Hippo pathway ...
Daniel, Ansari, Henrik, Ohlsson, Carl, Althini, Monika, Bauden, Qimin, Zhou, Dingyuan, Hu, Roland, Andersson   +6 more
openaire   +2 more sources

Neuroblastoma and Hippo Signaling Pathway

Journal of Dr. Behcet Uz Children s Hospital, 2021
Neuroblastoma (NB) is a malignant tumor often seen in early childhood and originating from the sympathetic nervous system.Hippo signal pathway is a mechanism involved in organ growth, differentiation and plays an important role in stem cells, cancer stem cells and tumorigenesis.YAP,which is the transcription co-activator, is an important part of this ...
Ozsengezer, Selen Kum, Altun, ZEKİYE SULTAN, Olgun, Nur   +2 more
openaire   +4 more sources

The Hippo Signaling Pathway: The Trader of Tumor Microenvironment [PDF]

Frontiers in Oncology, 2021
The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metastasis.
Duo Yang, Na Zhang, Meihua Li, Tao Hong, Wei Meng, Taohui Ouyang   +5 more
openaire   +3 more sources

Hippo dictates signaling for cellular homeostasis and immune defense in Crassostrea hongkongensis hemocytes

Frontiers in Immunology, 2023
IntroductionThe Hippo signaling pathway is an evolutionarily conserved signaling cascade that plays a crucial role in regulating cell proliferation, differentiation, and apoptosis.
Fan Mao, Fan Mao, Xiaoying Zheng, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Wenjie Yi, Jingchen Song, Jingchen Song, Jingchen Song, Shiwei Fu, Shiwei Fu, Shiwei Fu, Zhiming Xiang, Zhiming Xiang, Shu Xiao, Shu Xiao, Yongbo Bao, Ziniu Yu, Ziniu Yu, Yang Zhang, Yang Zhang   +21 more
doaj   +1 more source

The Hippo Signaling Pathway Manipulates Cellular Senescence. [PDF]

Cells
The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and their coactivators to maintain homeostasis. Therefore, the aberrant activation of the Hippo pathway and its associated molecules imposes significant stress on tissues and cells ...
Miyajima C, Nagasaka M, Aoki H, Toriuchi K, Yamanaka S, Hashiguchi S, Morishita D, Aoyama M, Hayashi H, Inoue Y.   +9 more
europepmc   +4 more sources

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

eLife, 2015
The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng, Wei Wang, Jianzhong Yu, Yonggang Zheng, Yun Qing, Duojia Pan   +5 more
doaj   +1 more source

The Hippo Pathway and Viral Infections

Frontiers in Microbiology, 2020
The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang, Wanhang Lu, Yiling Zhang, Feng Zou, Zhigang Jin, Tiejun Zhao   +5 more
doaj   +1 more source

The Hippo Signaling Pathway in Drug Resistance in Cancer [PDF]

Cancers, 2021
Chemotherapy represents one of the most efficacious strategies to treat cancer patients, bringing advantageous changes at least temporarily even to those patients with incurable malignancies. However, most patients respond poorly after a certain number of cycles of treatment due to the development of drug resistance.
Zeng, Renya, Dong, Jixin
openaire   +2 more sources

Clinical and biological implications of Hippo pathway dysregulation in sarcomas

Forum of Clinical Oncology, 2019
Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios, Zakopoulou Roubini, Zagouri Flora, Bamias Aristotelis, Dimopoulos Meletios Athanasios   +4 more
doaj   +1 more source

Roles of RUNX in Hippo Pathway Signaling [PDF]

, 2017
The Runt-domain (RD) transcription factors (RUNX genes) are an important family of transcriptional mediators that interact with a variety of proteins including the Hippo pathway effector proteins, YAP and TAZ. In this chapter we focus on two examples of RUNX-TAZ/YAP interactions that have particular significance in human cancer.
Antonino, Passaniti, Jessica L, Brusgard, Yiting, Qiao, Marius, Sudol, Megan, Finch-Edmondson   +4 more
openaire   +2 more sources