Results 21 to 30 of about 990,791 (254)

USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis

Cell Death and Disease, 2023
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive pathway for hepatocellular carcinogenesis.
Dongyi Liu, Quanhui Li, Yifeng Zang, Xin Li, Zhongbo Li, Peng Zhang, Chang Feng, Penghe Yang, Jiayao Cui, Yanan Sun, Tian Wei, Peng Su, Xin Zhao, Huijie Yang, Yinlu Ding   +14 more
doaj   +1 more source

The unfolding of the Hippo signaling pathway.

Developmental Biology, 2022
The development of a functional organ requires not only patterning mechanisms that confer proper identities to individual cells, but also growth-regulatory mechanisms that specify the final size of the organ.
Duojia Pan
semanticscholar   +1 more source

Hippo dictates signaling for cellular homeostasis and immune defense in Crassostrea hongkongensis hemocytes

Frontiers in Immunology, 2023
IntroductionThe Hippo signaling pathway is an evolutionarily conserved signaling cascade that plays a crucial role in regulating cell proliferation, differentiation, and apoptosis.
Fan Mao, Fan Mao, Xiaoying Zheng, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Wenjie Yi, Jingchen Song, Jingchen Song, Jingchen Song, Shiwei Fu, Shiwei Fu, Shiwei Fu, Zhiming Xiang, Zhiming Xiang, Shu Xiao, Shu Xiao, Yongbo Bao, Ziniu Yu, Ziniu Yu, Yang Zhang, Yang Zhang   +21 more
doaj   +1 more source

Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway

Molecular Medicine Reports, 2022
Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its prevalence is increasing in South Korea. The efficacy of combined treatment with natural product-derived and chemotherapy agents including curcumin combined with 5 ...
Dan Hu, R. Meng, Thi Van Nguyen, O. Chai, Byung-Hyun Park, Ju-Seog Lee, S. Kim   +6 more
semanticscholar   +1 more source

The Hippo Signaling Pathway in Development and Cancer

Developmental Cell, 2010
First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in ...
Duojia Pan
semanticscholar   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Improve Ovarian Function and Proliferation of Premature Ovarian Insufficiency by Regulating the Hippo Signaling Pathway

Frontiers in Endocrinology, 2021
Background Premature ovarian insufficiency (POI) is associated with severe physical damage and psychological burden on women. Transplantation of exosomes is an encouraging regenerative medicine method, which has the potential for restoring ovarian ...
Zhongkang Li, Mingle Zhang, Jiahua Zheng, Yanpeng Tian, Huihui Zhang, Yi Tan, Qian Li, Jingkun Zhang, Xianghua Huang   +8 more
semanticscholar   +1 more source

The Hippo Pathway and Viral Infections

Frontiers in Microbiology, 2020
The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang, Wanhang Lu, Yiling Zhang, Feng Zou, Zhigang Jin, Tiejun Zhao   +5 more
doaj   +1 more source

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

Cell Death and Disease, 2020
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. Circular RNA (circRNA) has been increasingly recognized as a crucial contributor to carcinogenesis. circRNA_0000140 has been aberrantly expressed in OSCC,
Qiu Peng, YaNan Cheng, Wenbing Zhang, H. Fan, Qiuhua Mao, Pu Xu   +5 more
semanticscholar   +1 more source

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

eLife, 2015
The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng, Wei Wang, Jianzhong Yu, Yonggang Zheng, Yun Qing, Duojia Pan   +5 more
doaj   +1 more source

The regulatory networks of the Hippo signaling pathway in cancer development

Journal of Cancer, 2021
The Hippo signaling pathway is a relatively young tumor-related signaling pathway. Although it was discovered lately, research on it developed rapidly.
Maonan Wang, Manli Dai, Dan Wang, Wei Xiong, Zhaoyang Zeng, Can Guo   +5 more
semanticscholar   +1 more source