Results 21 to 30 of about 33,422 (243)

The Hippo Signaling Pathway Interactome [PDF]

Science, 2013
Dissecting Hippo Interactions The Hippo signaling pathway plays key roles in many processes, from cell proliferation and cell death to regulation of stem cells and cancer cells. Kwon et al. (p.
Kwon, Young, Vinayagam, Arunachalam, Sun, Xiaoyun, Dephoure, Noah, Gygi, Steven, Hong, Pengyu, Perrimon, Norbert   +6 more
openaire   +3 more sources

Neuroblastoma and Hippo Signaling Pathway

Journal of Dr. Behcet Uz Children s Hospital, 2021
Neuroblastoma (NB) is a malignant tumor often seen in early childhood and originating from the sympathetic nervous system.Hippo signal pathway is a mechanism involved in organ growth, differentiation and plays an important role in stem cells, cancer stem cells and tumorigenesis.YAP,which is the transcription co-activator, is an important part of this ...
Ozsengezer, Selen Kum, Altun, ZEKİYE SULTAN, Olgun, Nur   +2 more
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The Hippo signaling pathway in gastric cancer

Acta Biochimica et Biophysica Sinica, 2023
Gastric cancer (GC) is an aggressive malignant disease which still lacks effective early diagnosis markers and targeted therapies, representing the fourth-leading cause of cancer-associated death worldwide. The Hippo signaling pathway plays crucial roles in organ size control and tissue homeostasis under physiological conditions, yet its aberrations ...
Cao Zhifa, An Liwei, Han Yi, Jiao Shi, Zhou Zhaocai   +4 more
openaire   +3 more sources

The Hippo Signaling Pathway Manipulates Cellular Senescence. [PDF]

Cells
The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and their coactivators to maintain homeostasis. Therefore, the aberrant activation of the Hippo pathway and its associated molecules imposes significant stress on tissues and cells ...
Miyajima C, Nagasaka M, Aoki H, Toriuchi K, Yamanaka S, Hashiguchi S, Morishita D, Aoyama M, Hayashi H, Inoue Y.   +9 more
europepmc   +4 more sources

Hippo signaling pathway in polycystic ovary syndrome. [PDF]

Front Endocrinol (Lausanne)
Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder syndrome, that predominantly affects women of reproductive age. It is characterized by marked clinical heterogeneity involving multiple systems including reproductive, metabolic and immune systems, while existing diagnostic protocols remain inadequate for clinical needs ...
Wen J, Cheng G, Zhang Y, Liu S.
europepmc   +2 more sources

The Hippo Signaling Pathway in Pancreatic Cancer [PDF]

Anticancer Research, 2019
Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration. Dysregulation of the Hippo pathway has been recognized in a variety of human cancers, including pancreatic cancer. YES-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the two major downstream effectors of the Hippo pathway ...
Daniel, Ansari, Henrik, Ohlsson, Carl, Althini, Monika, Bauden, Qimin, Zhou, Dingyuan, Hu, Roland, Andersson   +6 more
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USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis

Cell Death and Disease, 2023
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive pathway for hepatocellular carcinogenesis.
Dongyi Liu, Quanhui Li, Yifeng Zang, Xin Li, Zhongbo Li, Peng Zhang, Chang Feng, Penghe Yang, Jiayao Cui, Yanan Sun, Tian Wei, Peng Su, Xin Zhao, Huijie Yang, Yinlu Ding   +14 more
doaj   +1 more source

Hippo dictates signaling for cellular homeostasis and immune defense in Crassostrea hongkongensis hemocytes

Frontiers in Immunology, 2023
IntroductionThe Hippo signaling pathway is an evolutionarily conserved signaling cascade that plays a crucial role in regulating cell proliferation, differentiation, and apoptosis.
Fan Mao, Fan Mao, Xiaoying Zheng, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Wenjie Yi, Jingchen Song, Jingchen Song, Jingchen Song, Shiwei Fu, Shiwei Fu, Shiwei Fu, Zhiming Xiang, Zhiming Xiang, Shu Xiao, Shu Xiao, Yongbo Bao, Ziniu Yu, Ziniu Yu, Yang Zhang, Yang Zhang   +21 more
doaj   +1 more source

Phosphatidic Acid Signals via the Hippo Pathway [PDF]

Molecular Cell, 2018
In this issue of Molecular Cell, Han et al. (2018) show that phosphatidic acid inhibits the action of the LATS kinases, key mediators of Hippo pathway signaling, which leads to an increase in the nuclear activity of the transcriptional regulator YAP.
Eleni, Stampouloglou, Xaralabos, Varelas
openaire   +2 more sources

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

eLife, 2015
The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng, Wei Wang, Jianzhong Yu, Yonggang Zheng, Yun Qing, Duojia Pan   +5 more
doaj   +1 more source