Results 31 to 40 of about 990,791 (254)
Cancer Letters, 2021 Long noncoding RNAs (lncRNAs) play an important role in the regulation of gene expression and are involved in several pathological responses. However, many important lncRNAs in breast cancer have not been identified and their expression levels and ...
Maonan Wang +12 more
semanticscholar +1 more source
Clinical and biological implications of Hippo pathway dysregulation in sarcomas
Forum of Clinical Oncology, 2019 Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios +4 more
doaj +1 more source
Oncology Letters, 2021 MicroRNA-30a-5p (miR-30a-5p), which functions as a tumor suppressor, has been reported to be downregulated in colorectal cancer (CRC) tissues and to be associated with cancer invasion.
Dan Yu +12 more
semanticscholar +1 more source
The Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis
Cancer Cell International, 2021 Cancer can be considered as a communication disease between and within cells; nevertheless, there is no effective therapy for the condition, and this disease is typically identified at its late stage.
Negar Noorbakhsh +4 more
semanticscholar +1 more source
A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft Tissue Sarcomas
Frontiers in Oncology, 2015 The Hippo signaling pathway is an evolutionarily conserved developmental network vital for the regulation of organ size, tissue homeostasis, repair and regeneration, and cell fate. The Hippo pathway has also been shown to have tumor suppressor properties.
Michael D Deel +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques.
Madison Irwin +15 more
doaj +1 more source
Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway
Journal of experimental & clinical cancer research : CR, 2021 Circular RNAs (circRNAs), a novel class of endogenous RNAs, have shown to participate in the development of breast cancer (BC). Hsa_circ_0005273 is a circRNA generated from several exons of PTK2. However, the potential functional role of hsa_circ_0005273
Xuehui Wang +8 more
semanticscholar +1 more source
GPCR-Hippo Signaling in Cancer
Cells, 2019 The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies
Jiaqian Luo, Fa-Xing Yu
doaj +1 more source
Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. [PDF]
PLoS ONE, 2012 Epithelial cells are the major cell-type for all organs in multicellular organisms. In order to achieve correct organ size, epithelial tissues need mechanisms that limit their proliferation, and protect tissues from damage caused by defective epithelial ...
Shilpi Verghese +4 more
doaj +1 more source
Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
Cell Reports, 2018 SUMMARY Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional “omic” data from The ...
Yumeng Wang +21 more
semanticscholar +1 more source