Results 31 to 40 of about 33,422 (243)

Hippo signaling pathway and organ size control [PDF]

Fly, 2009
Initially discovered in Drosophila, the Hippo (Hpo) pathway has been recognized as a conserved signaling pathway that controls organ size during development by restricting cell growth and proliferation and by promoting apoptosis. In addition, abnormal activities of several Hpo pathway components have been implicated in human cancer. Here, we review the
Lei, Zhang, Tao, Yue, Jin, Jiang
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The Hippo Pathway and Viral Infections

Frontiers in Microbiology, 2020
The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang, Wanhang Lu, Yiling Zhang, Feng Zou, Zhigang Jin, Tiejun Zhao   +5 more
doaj   +1 more source

Clinical and biological implications of Hippo pathway dysregulation in sarcomas

Forum of Clinical Oncology, 2019
Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios, Zakopoulou Roubini, Zagouri Flora, Bamias Aristotelis, Dimopoulos Meletios Athanasios   +4 more
doaj   +1 more source

A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft Tissue Sarcomas

Frontiers in Oncology, 2015
The Hippo signaling pathway is an evolutionarily conserved developmental network vital for the regulation of organ size, tissue homeostasis, repair and regeneration, and cell fate. The Hippo pathway has also been shown to have tumor suppressor properties.
Michael D Deel, Michael D Deel, Jenny J Li, Lisa E. S. Crose, Corinne M Linardic, Corinne M Linardic, Corinne M Linardic   +6 more
doaj   +1 more source

Roles of RUNX in Hippo Pathway Signaling [PDF]

, 2017
The Runt-domain (RD) transcription factors (RUNX genes) are an important family of transcriptional mediators that interact with a variety of proteins including the Hippo pathway effector proteins, YAP and TAZ. In this chapter we focus on two examples of RUNX-TAZ/YAP interactions that have particular significance in human cancer.
Antonino, Passaniti, Jessica L, Brusgard, Yiting, Qiao, Marius, Sudol, Megan, Finch-Edmondson   +4 more
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GPCR-Hippo Signaling in Cancer

Cells, 2019
The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies
Jiaqian Luo, Fa-Xing Yu
doaj   +1 more source

New Therapeutic Approach for Targeting Hippo Signalling Pathway [PDF]

Scientific Reports, 2019
AbstractNuclear localization signals are short amino acid sequences that target proteins for nuclear import. In this manuscript, we have generated a chimeric tri-functional peptide composed of a cell penetrating peptide (CPP), a nuclear localization sequence and an interfering peptide blocking the interaction between TEAD and YAP, two transcription ...
Dominguez-Berrocal, Leticia, Cirri, Erica, Zhang, Xiguang, Andrini, Laura, Marin, Gustavo, Lebel-Binay, Sophie, Rebollo, Angelita   +6 more
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A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration

Frontiers in Cell and Developmental Biology, 2020
Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques.
Madison Irwin, Meghana Tare, Aditi Singh, Oorvashi Roy Puli, Neha Gogia, Matthew Riccetti, Prajakta Deshpande, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh   +15 more
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The Spectrin cytoskeleton regulates the Hippo signalling pathway [PDF]

The EMBO Journal, 2015
The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling. In the developing Drosophila wing and eye, loss of apical Spectrins (alpha/beta-heavy dimers) produces tissue overgrowth and mis-regulation of Hippo target genes, similar
Fletcher, GC, Elbediwy, A, Khanal, I, Ribeiro, PS, Tapon, N, Thompson, BJ   +5 more
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The Hippo Pathway Regulates Wnt/β-Catenin Signaling [PDF]

Developmental Cell, 2010
Several developmental pathways contribute to processes that regulate tissue growth and organ size. The Hippo pathway has emerged as one such critical regulator. However, how Hippo signaling is integrated with other pathways to coordinate these processes remains unclear.
Varelas, Xaralabos, Miller, Bryan W., Sopko, Richelle, Song, Siyuan, Gregorieff, Alex, Fellouse, Frederic A., Sakuma, Rui, Pawson, Tony, Hunziker, Walter, McNeill, Helen, Wrana, Jeffrey L., Attisano, Liliana   +11 more
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