Results 31 to 40 of about 34,290 (249)
Frontiers in Cell and Developmental Biology, 2020 Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques.
Madison Irwin +15 more
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A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft Tissue Sarcomas
Frontiers in Oncology, 2015 The Hippo signaling pathway is an evolutionarily conserved developmental network vital for the regulation of organ size, tissue homeostasis, repair and regeneration, and cell fate. The Hippo pathway has also been shown to have tumor suppressor properties.
Michael D Deel +6 more
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Targeting the Hippo signalling pathway for cancer treatment [PDF]
Journal of Biochemistry, 2016 The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced ...
Keisuke, Nakatani +9 more
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GPCR-Hippo Signaling in Cancer
Cells, 2019 The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies
Jiaqian Luo, Fa-Xing Yu
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Vamana Couples Fat Signaling to the Hippo Pathway [PDF]
Developmental Cell, 2016 The protocadherins Dachsous and Fat initiate a signaling pathway that controls growth and planar cell polarity by regulating the membrane localization of the atypical myosin Dachs. How Dachs is regulated by Fat signaling has remained unclear. Here we identify the vamana gene as playing a crucial role in regulating membrane localization of Dachs and in ...
Jyoti R, Misra, Kenneth D, Irvine
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A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
Cell Reports, 2020 Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored.
Lingli He +17 more
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The Hippo Signaling Pathway in Development and Cancer [PDF]
Developmental Cell, 2010 First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival ...
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Phosphatidic Acid Signals via the Hippo Pathway [PDF]
Molecular Cell, 2018 In this issue of Molecular Cell, Han et al. (2018) show that phosphatidic acid inhibits the action of the LATS kinases, key mediators of Hippo pathway signaling, which leads to an increase in the nuclear activity of the transcriptional regulator YAP.
Eleni, Stampouloglou, Xaralabos, Varelas
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Regulation of Hippo signaling by metabolic pathways in cancer
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022 Hippo signaling is known to maintain balance between cell proliferation and apoptosis via tight regulation of factors, such as metabolic cues, cell-cell contact, and mechanical cues. Cells directly recognize glucose, lipids, and other metabolic cues and integrate multiple signaling pathways, including Hippo signaling, to adjust their proliferation and ...
Ukjin, Lee +2 more
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Research progress of the Hippo signaling pathway in renal cell carcinoma [PDF]
Asian Journal of UrologyYiren Yang, Baohua Zhu, Xiaolei Shi
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