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The Hippo signaling pathway in development and regeneration
Cell ReportsSummary: The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics
Zhenxing Zhong, Zhihan Jiao, Fa-Xing Yu
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Premetazoan Origin of the Hippo Signaling Pathway
Cell Reports, 2012 Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of
Arnau Sebé-Pedrós +3 more
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Hippo Signaling Pathway in Pancreas Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity.
Yifan Wu +6 more
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The Hippo signaling pathway: from multiple signals to the hallmarks of cancers
Acta Biochimica et Biophysica Sinica, 2023 Evolutionarily conserved, the Hippo signaling pathway is critical in regulating organ size and tissue homeostasis. The activity of this pathway is tightly regulated under normal circumstances, since its physical function is precisely maintained to ...
Zhu Ning +6 more
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Zyxin links fat signaling to the hippo pathway.
PLoS Biology, 2011 The Hippo signaling pathway has a conserved role in growth control and is of fundamental importance during both normal development and oncogenesis. Despite rapid progress in recent years, key steps in the pathway remain poorly understood, in part due to ...
Cordelia Rauskolb +4 more
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Role of Hippo Signaling Pathway in Lung Cancer
Chinese Journal of Lung Cancer, 2017 Lung cancer is the leading cause of cancer related mortality in the world, with more than 1 million deaths per year, accounting for about one fifth of all cancer deaths worldwide.
Yuechao LIU, Ying XING, Li CAI
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The Hippo pathway mediates Semaphorin signaling [PDF]
Science Advances, 2022 Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear.
Zhipeng Meng +16 more
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Hippo signaling pathway in polycystic ovary syndrome. [PDF]
Front Endocrinol (Lausanne)Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder syndrome, that predominantly affects women of reproductive age. It is characterized by marked clinical heterogeneity involving multiple systems including reproductive, metabolic and immune systems, while existing diagnostic protocols remain inadequate for clinical needs ...
Wen J, Cheng G, Zhang Y, Liu S.
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The Hippo signaling pathway in gastric cancer
Acta Biochimica et Biophysica Sinica, 2023 Gastric cancer (GC) is an aggressive malignant disease which still lacks effective early diagnosis markers and targeted therapies, representing the fourth-leading cause of cancer-associated death worldwide. The Hippo signaling pathway plays crucial roles in organ size control and tissue homeostasis under physiological conditions, yet its aberrations ...
Cao Zhifa +4 more
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The Hippo Signaling Pathway Interactome [PDF]
Science, 2013 Dissecting Hippo Interactions The Hippo signaling pathway plays key roles in many processes, from cell proliferation and cell death to regulation of stem cells and cancer cells. Kwon et al. (p.
Kwon, Young +6 more
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