Results 11 to 20 of about 33,422 (243)
Hippo Signaling Pathway in Pancreas Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity.
Yifan Wu +6 more
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Premetazoan Origin of the Hippo Signaling Pathway
Cell Reports, 2012 Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of
Arnau Sebé-Pedrós +3 more
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The Hippo signaling pathway in development and regeneration
Cell ReportsSummary: The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics
Zhenxing Zhong, Zhihan Jiao, Fa-Xing Yu
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The Hippo signaling pathway and stem cell biology [PDF]
Trends in Cell Biology, 2012 Stem cell (SC) activity fluctuates throughout an organism's lifetime to maintain homeostatic conditions in all tissues. As animals develop and age, their organs must remodel and regenerate themselves in response to environmental and physiological demands. Recently, the highly conserved Hippo signaling pathway, discovered in Drosophila melanogaster, has
Azucena, Ramos, Fernando D, Camargo
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The Hippo Signaling Pathway in Development and Disease [PDF]
Developmental Cell, 2019 The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future ...
Yonggang, Zheng, Duojia, Pan
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Zyxin links fat signaling to the hippo pathway.
PLoS Biology, 2011 The Hippo signaling pathway has a conserved role in growth control and is of fundamental importance during both normal development and oncogenesis. Despite rapid progress in recent years, key steps in the pathway remain poorly understood, in part due to ...
Cordelia Rauskolb +4 more
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Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways [PDF]
Frontiers in Cell and Developmental Biology, 2020 Studies in yeast first delineated the function of Mob proteins in kinase pathways that regulate cell division and shape; in multicellular eukaryotes Mobs regulate tissue growth and morphogenesis.
Juan Carlos Duhart, Laurel A. Raftery
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How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases [PDF]
Journal of Immunology Research, 2018 Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease ...
Wenyi Zhou, Mingyi Zhao
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Hippo Signaling Pathway in Gliomas [PDF]
Cells, 2021 The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits
Konstantin Masliantsev +2 more
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The Hippo pathway mediates Semaphorin signaling [PDF]
Science Advances, 2022 Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear.
Zhipeng Meng +16 more
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