Results 11 to 20 of about 990,791 (254)

Hippo Signaling Pathway in Pancreas Development

Frontiers in Cell and Developmental Biology, 2021
The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity.
Yifan Wu, Yifan Wu, Pauline Aegerter, Michael Nipper, Logan Ramjit, Jun Liu, Pei Wang   +6 more
doaj   +2 more sources

Toxoplasma gondii induces MST2 phosphorylation mediating the activation of hippo signaling pathway to promote apoptosis and lung tissue damage [PDF]

iScience
Summary: Toxoplasma gondii (T. gondii) is an intracellular parasite, and its regulation of host cell apoptosis directly affects its parasitism. Studies link T. gondii-induced apoptosis to abnormal expression of mammalian STE20-like protein kinase 2 (MST2)
Kangzhi Xu, Shifan Zhu, Fan Xu, Jin Yang, Bin Deng, Dingzeyang Su, Jing Ma, Mingyue Zu, Yifan Lin, Tianxu Pei, Yuyang Zhu, Lele Wang, Dandan Liu, Qiangde Duan, Jinjun Xu, Zhiming Pan, Jianping Tao, Zhaofeng Hou   +17 more
doaj   +2 more sources

An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
The most frequent reason of morbidity and mortality in the world, cerebral ischemia sets off a chain of molecular and cellular pathologies that associated with some central nervous system (CNS) disorders mainly including ischemic stroke, Alzheimer's ...
Xuan Wei, Guangshan Huang, Ji-yong Liu, Jinwen Ge, Wenli Zhang, Zhigang Mei   +5 more
semanticscholar   +1 more source

Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential

MedComm, 2023
As highly conserved among diverse species, Hippo signaling pathway regulates various biological processes, including development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size.
Liemei Lv, Xiangxiang Zhou
doaj   +1 more source

The Hippo signaling pathway in gastric cancer

Acta Biochimica et Biophysica Sinica, 2023
Gastric cancer (GC) is an aggressive malignant disease which still lacks effective early diagnosis markers and targeted therapies, representing the fourth-leading cause of cancer-associated death worldwide. The Hippo signaling pathway plays crucial roles
Zhifa Cao, L. An, Yi Han, S. Jiao, Zhaocai Zhou   +4 more
semanticscholar   +1 more source

White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki To Promote Its Infection in Penaeus vannamei

Microbiology Spectrum, 2023
White spot syndrome virus (WSSV) is a serious threat to shrimp aquaculture, especially Pacific white shrimp, Penaeus vannamei, the most farmed shrimp in the world.
Linwei Yang, Zi-Ang Wang, Ran Geng, Hengwei Deng, Shengwen Niu, Hongliang Zuo, Shaoping Weng, Jianguo He, Xiaopeng Xu   +8 more
doaj   +1 more source

Emerging roles of the Hippo signaling pathway in modulating immune response and inflammation‐driven tissue repair and remodeling

The FEBS Journal, 2022
Inflammation is an evolutionarily conserved process and part of the body's defense mechanism. Inflammation leads to the activation of immune and non‐immune cells that protect the host tissue/organs from injury or intruding pathogens. The Hippo pathway is
Masum M. Mia, Manvendra K. Singh
semanticscholar   +1 more source

Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice

Theranostics, 2021
Rationale: Mitochondrial dysfunction facilitates heart failure development forming a therapeutic target, but the mechanism involved remains unclear. We studied whether the Hippo signaling pathway mediates mitochondrial abnormalities that results in onset
Wei Wu, M. Ziemann, K. Huynh, Gang She, Zheng-Da Pang, Yi Zhang, T. Duong, H. Kiriazis, Tian-Tian Pu, Ru-Yue Bai, Jing-Jing Li, Yu Zhang, Ming-Xia Chen, J. Sadoshima, Xiu-Ling Deng, P. Meikle, Xiaojun Du   +16 more
semanticscholar   +1 more source

The Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective

Cancers, 2021
Simple Summary Cancer is increasingly viewed as a cell cycle disease in that the dysregulation of the cell cycle machinery is a common feature in cancer.
Yi Xiao, Jixin Dong
semanticscholar   +1 more source

Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral response

bioRxiv, 2022
SARS-CoV-2, responsible for the COVID-19 pandemic, causes respiratory failure and damage to multiple organ systems. The emergence of viral variants poses a risk of vaccine failures and prolongation of the pandemic.
G. Garcia, A. V. Jeyachandran, Yijie Wang, Joseph Ignatius Irudayam, S. Cario, C. Sen, Shen Li, Yunfeng Li, Ashok Kumar, K. Nielsen‐Saines, S. French, Priya S. Shah, K. Morizono, B. Gomperts, Arjun Deb, A. Ramaiah, V. Arumugaswami   +16 more
semanticscholar   +1 more source