Results 181 to 190 of about 56,531 (215)
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Regulation of hippocampal neurogenesis in adulthood
Biological Psychiatry, 2000A substantial number of new granule neurons are produced in the dentate gyrus in adulthood in a variety of mammalian species, including humans. Numerous studies have demonstrated that the production and survival of new hippocampal neurons can be enhanced or diminished by hormones and experience.
E, Gould +3 more
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Adult hippocampal neurogenesis and aging
European Archives of Psychiatry and Clinical Neuroscience, 2007The demographic changes in the foreseeable future stress the need for research on successful cognitive aging. Advancing age constitutes a primary risk factor for disease of the central nervous system most notably neurodegenerative disorders. The hippocampus is one of the brain regions that is prominently affected by neurodegeneration and functional ...
Friederike, Klempin, Gerd, Kempermann
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Ghrelin mediated hippocampal neurogenesis
2022The stomach hormone, ghrelin, which is released during food restriction, provides a link between circulating energy state and adaptive brain function. The maintenance of such homeostatic systems is essential for an organism to survive and thrive, and accumulating evidence points to ghrelin being a key regulator of adult hippocampal neurogenesis and ...
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Antidepressants and Hippocampal Neurogenesis
Science Signaling, 2003Antidepressants can cause rapid increases in serotonin and noradrenaline levels in patients, but usually the clinical benefits are not seen until 3 or 4 weeks have passed. One possible explanation for this delay is that antidepressant drugs change the mood of patients by stimulating neurogenesis.
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CDK2 is Dispensable for Adult Hippocampal Neurogenesis
Cell Cycle, 2007Granule neurons of the dentate gyrus (DG) of the hippocampus undergo continuous renewal throughout life. Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry. We used Cdk2-deficient mice to decipher the requirement of Cdk2 for the generation of new neurons in the adult hippocampus.
Vandenbosch, Renaud +10 more
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Hippocampal Neurogenesis and Ageing
2012Although significant inconsistencies remain to be clarified, a role for neurogenesis in hippocampal functions, such as cognition, has been suggested by several reports. Yet, investigation in various species of mammals, including humans, revealed that rates of hippocampal neurogenesis are steadily declining with age.
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Hippocampal Neurogenesis in Epileptogenesis
Neuroscience and Behavioral Physiology, 2020This review presents data on the characteristics of the reorganization of the hippocampus associated with impairment to neurogenesis in epileptiform states of different etiologies. Data on the effects of convulsive states of different severities and frequencies on the levels of proliferation, migration, and insertion of new cells into the hippocampal ...
E. V. Nasluzova +2 more
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NPY and Hippocampal Neurogenesis
2005The chronic behavioural and cognitive effects of NPY may be partly mediated by Y1 receptor effects on stem cell proliferation and neurogenesis in the dentate gyrus of the adult hippocampus. Further investigation of this mechanism of NPY function is likely to be helpful is dissociating the acute and chronic effects of NPY on cognition and behaviour and ...
William P. Gray, Helen E. Scharfman
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A window on hippocampal neurogenesis
Science, 2018Neurodevelopment![Figure][1] Watching the birth and growth of new neurons in the living brain CREDIT: GREGOR PILZ AND SARA BOTTES/BRAIN RESEARCH INSTITUTE, UNIVERSITY OF ZURICH Addition of new neurons to the adult brain is key to the hippocampal functions of learning and memory.
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GABAergic Regulation of Adult Hippocampal Neurogenesis
Molecular Neurobiology, 2016Adult hippocampal neurogenesis has been implicated in several brain functions, including learning and memory processes. It also plays an important role in the aetiology of anxiety disorders, depression and age-related deficits. The endogenous stem cell pool is also known to hold great potential for ameliorating the diseased or aged brain.
Sibbe, Mirjam, Kulik, Akos
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