Comparative Study of Lefaxin Family in Two Asian Leeches: <i>Hirudinaria manillensis</i> and <i>Whitmania pigra</i>. [PDF]
Biology (Basel)Ye T +8 more
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Mechanisms and research progress of insect-derived medicines in intervention for ischemic stroke. [PDF]
IBRO Neurosci RepXu C, Guan Y.
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LigExtract: Large-scale Automated Identification of Ligands from Protein Structures in the Protein Data Bank. [PDF]
Genomics Proteomics BioinformaticsAniceto N +3 more
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Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Demonstrate Thrombin Liability. [PDF]
ACS Pharmacol Transl SciWebb EM, Cassada JB, Hamm HE.
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The clinical efficacy of herbal medicines containing leeches in the treatment of coronary heart disease: a systematic review and meta-analysis. [PDF]
Front PharmacolZiyuan Z +4 more
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Retraction: Hirudin ameliorates immunoglobulin a nephropathy by inhibition of fibrosis and inflammatory response. [PDF]
Ren Faileuropepmc +1 more source
A Comparison of Hirudin with Heparin in the Prevention of Restenosis after Coronary Angioplasty [PDF]
New England Journal of Medicine, 1995 __Background:__ The likelihood of restenosis is a major limitation of coronary angioplasty. We studied whether hirudin, a highly selective inhibitor of thrombin with irreversible effects, would prevent restenosis after angioplasty.
Patrick W Serruys +2 more
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Hirudin is a direct thrombin inhibitor derived from leeches. Recombinant forms of hirudin are under development by a number of manufacturers, the most advanced of which are undergoing phase II clinical trials. Ciba-Geigy's desulfatohirudin [CGP 39393] and Hoechst's HBW 023 have been the agents used in a number of clinical trials to date.
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