Results 151 to 160 of about 7,899 (213)

Identification and functional characterization of multiple haemadins and an oligomeric decorsin in the Asian land leech Haemadipsa interrupta. [PDF]

Parasitol Res
Müller C, Sponholz D, Tolksdorf C, Rauch BH, Kvist S.   +4 more
europepmc   +1 more source

Comparative Study of Lefaxin Family in Two Asian Leeches: <i>Hirudinaria manillensis</i> and <i>Whitmania pigra</i>. [PDF]

Biology (Basel)
Ye T, Zhao F, Xiao M, Yin J, Ai R, Tang L, Liu Z, Huang Z, Lin G.   +8 more
europepmc   +1 more source

Mechanisms and research progress of insect-derived medicines in intervention for ischemic stroke. [PDF]

IBRO Neurosci Rep
Xu C, Guan Y.
europepmc   +1 more source

LigExtract: Large-scale Automated Identification of Ligands from Protein Structures in the Protein Data Bank. [PDF]

Genomics Proteomics Bioinformatics
Aniceto N, Martinho N, Rufino I, Guedes RC.   +3 more
europepmc   +1 more source

Anti-hirudin antibodies alter pharmacokinetics and pharmacodynamics of recombinant hirudin

Thrombosis and Haemostasis, 2003
SummaryRecombinant hirudin (r-hirudin) is a potent direct thrombin inhibitor with immunogenic properties. Anti-hirudin antibodies (aHAb) are detected in up to 74% of patients treated with r-hirudin for more than 5 days. aHAb may alter the pharmaco-kinetics and pharmacodynamics of r-hirudin.The effects of aHAb on the pharmacokinetics of r-hirudin were ...
Hudek, Renata, Piazolo, Lukas, Haase, Karl Konstantin, Borggrefe, Martin, Huhle, Günter, Fischer, Karl-Georg, Liebe, Volker   +6 more
openaire   +4 more sources

The functional domain of hirudin, a thrombin-specific inhibitor

FEBS Letters, 1983
Hirudin is a thrombin-specific of Mr 8000 (65 amino acid residues). Native hirudin contains 3 disulfide linkages within the first 39 amino-terminal residues, and highly C-terminal segment which is freely accessible to enzyme digestion by both endo- and ...
J Y Chang
exaly   +2 more sources

A novel natural hirudin facilitated anti-clotting polylactide membrane via hydrogen bonding interaction

Journal of Membrane Science, 2017
Different from intensively used anticoagulant heparin, hirudin as a representative of natural bio-molecular inhibitors can form specific hirudin-thrombin complex and function as a serine proteinase to efficiently prevent blood coagulation with less ...
Fu Liu, Zhu Xiong
exaly   +1 more source

Interaction of site specific hirudin variants with α-thrombin

FEBS Letters, 1988
The kinetics of complex formation between recombinant hirudin or recombinant hirudin mutants with thrombin were analyzed. In order to elucidate the inhibitor's reactive site peptide bond predetermined amino acid substitutions were introduced at positions
Johannes Dodt, Antonio Baici
exaly   +2 more sources