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Blood, 2011
Abstract Abstract 4321 Recombinant versions of hirudin such as lepirudin (Refludan®) and desirudin (Iprivask®) are currently used as parenteral anticoagulants for various indications. The recombinant hirudin preparations differ from the natural hirudin in lacking a sulfate group on tyrosine at the 63rd position and a ...
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Abstract Abstract 4321 Recombinant versions of hirudin such as lepirudin (Refludan®) and desirudin (Iprivask®) are currently used as parenteral anticoagulants for various indications. The recombinant hirudin preparations differ from the natural hirudin in lacking a sulfate group on tyrosine at the 63rd position and a ...
Vijaya L Paramatmuni +5 more
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Pharmacology of Recombinant Hirudin
Seminars in Thrombosis and Hemostasis, 2002Hirudin is the anticoagulative product of the salivary glands of the medical leech Hirudo medicinalis. It is characterized by a direct, bifunctional inhibition mechanism and a high, exclusive specificity and a strong ability to bind to thrombin (tight binding).
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Hirudin for Diagnostic Purposes
Pathophysiology of Haemostasis and Thrombosis, 1991Hirudin serves as a versatile tool for the control of thrombin activity in hemostaseology. It may be added in excess to blood, plasma or test mixtures to prevent catalytic and nonenzymatic effects of thrombin. It may be used to quench thrombin activity upon extensive or limited action.
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Hirudin In Renal Insufficiency
Seminars in Thrombosis and Hemostasis, 2002Recombinant hirudins (r-hirudins) are potent direct thrombin inhibitors increasingly used for alternative anticoagulation, especially in heparin-induced thrombocytopenia. R-hirudins are almost exclusively eliminated by the kidneys, and a close correlation between r-hirudin clearance and endogenous creatinine clearance has been observed.
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BioDrugs, 1998
Hirudin is a specific thrombin inhibitor which acts independent of antithrombin III and is able to bind to fluid phase and clot bound thrombin. It has become available for clinical use by production with recombinant techniques just recently. Hirudin produces a relatively stable level of anticoagulation when compared with heparin.
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Hirudin is a specific thrombin inhibitor which acts independent of antithrombin III and is able to bind to fluid phase and clot bound thrombin. It has become available for clinical use by production with recombinant techniques just recently. Hirudin produces a relatively stable level of anticoagulation when compared with heparin.
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Seminars in Thrombosis and Hemostasis, 2002
Fischer, Karl-Georg, Sutor, Anton H.
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Fischer, Karl-Georg, Sutor, Anton H.
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