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Hirudin In Renal Insufficiency
Seminars in Thrombosis and Hemostasis, 2002Recombinant hirudins (r-hirudins) are potent direct thrombin inhibitors increasingly used for alternative anticoagulation, especially in heparin-induced thrombocytopenia. R-hirudins are almost exclusively eliminated by the kidneys, and a close correlation between r-hirudin clearance and endogenous creatinine clearance has been observed.
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BioDrugs, 1998
Hirudin is a specific thrombin inhibitor which acts independent of antithrombin III and is able to bind to fluid phase and clot bound thrombin. It has become available for clinical use by production with recombinant techniques just recently. Hirudin produces a relatively stable level of anticoagulation when compared with heparin.
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Hirudin is a specific thrombin inhibitor which acts independent of antithrombin III and is able to bind to fluid phase and clot bound thrombin. It has become available for clinical use by production with recombinant techniques just recently. Hirudin produces a relatively stable level of anticoagulation when compared with heparin.
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Seminars in Thrombosis and Hemostasis, 2002
Fischer, Karl-Georg, Sutor, Anton H.
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Fischer, Karl-Georg, Sutor, Anton H.
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Hirudin and hirudin-based peptides.
Methods in enzymology, 1994S R, Stone, J M, Maraganore
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